Health surveillance of Gulf War I veterans exposed to depleted uranium: Updating the cohort

Health Physics

Volumn 93, Issue 1, 2007, Pages 60-73

  McDiarmid, M A ^a,b   Engelhardt, S M ^b,f   Oliver, M ^a,b   Gucer, P ^a,b   Wilson, P D ^a   Kane, R ^a,b   Cernich, A ^a,b   Kaup, B ^a,b   Anderson, L ^a   Hoover, D ^a   Brown, L ^a,b   Albertini, R ^c   Gudi, R ^d   Jacobson Kram, D ^e   Squibb, K S ^a,b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b BALTIMORE VA MEDICAL CENTER   (United States)

^c UNIVERSITY OF VERMONT   (United States)

^d BioReliance   (United States)

^e CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^f Occupational Health Program   (United States)

Author keywords

Excretion, urinary; Exposure, cumulative; Health effects; Uranium, depleted

Indexed keywords

BIOLOGICAL MARKER; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; RETINOL BINDING PROTEIN; URANIUM;

ADULT; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE LOCUS; HEALTH SURVEY; HUMAN; KIDNEY FUNCTION; KIDNEY PROXIMAL TUBULE; PRIORITY JOURNAL; PROTEIN URINE LEVEL; RADIATION EXPOSURE; SOLDIER; WAR;

ADULT; CHROMOSOME ABERRATIONS; GULF WAR; HEALTH SURVEYS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MIDDLE AGED; MILITARY PERSONNEL; MUTATION; OCCUPATIONAL EXPOSURE; POPULATION SURVEILLANCE; RETINOL-BINDING PROTEINS; SEMEN; URANIUM; VETERANS;

EID: 34250350312     PISSN: 00179078     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.HP.0000259850.66969.8c     Document Type: Article

References (67)

1. Agency for Toxic Substances and Disease Registry. Toxicological profile for uranium (update). Washington, DC: U.S. Department of Health and Human Services, Public Health Service, ATSDR; 1999.
2. Army Environmental Policy Institute. Health and environmental consequences of depleted uranium use in the US army. Arlington, VA: AEPI; 1995.
3. Bleecker ML, Ford DP, Lindgren KN, Scheetz K, Tiburzi MJ. Association of chronic and current measures of lead exposure with different components of brainstem auditory evoked potentials. Neurotoxicol 24:625-631; 2003.
4. Chia SE, Chia HP, Ong CN, Jeyaratnam J. Cumulative blood lead levels and neurobehavioral test performance. Neurotoxicol 18:793- 803; 1997.
5. Coryell VH, Stearns DM. Molecular analysis of hprt mutations generated in Chinese Hamster Ovary EM9 cells by uranyl acetate, by hydrogen peroxide and spontaneously. Mol Carcinog 45:60-72; 2006.
6. Cross FT, Palmer RF, Busch RH, Filipy RE, Stuart BO. Development of lesions in Syrian Golden hamsters following exposure to radon daughters and uranium ore dust. Health Phys 41:135-153; 1981.
7. Delis DC, Kramer JH, Kaplan E, Ober BA. California verbal learning test. San Antonio, TX: The Psychological Corporation; 2000.
8. Dewald GW, Therneau T, Larson D, Lee YK, Fink S, Smoley S, Paternoster S, Adeyinka A, Ketterling R, Van Dyke DL, Fonseca R, Kyle R. Relationsip of patient survival and chromosome anomalies detected in metaphase and or interphase cells at diagnosis of myeloma. Blood 106:3553-3558; 2005.
9. Eckerman K. Limiting values of radionuclide intake and air concentration and dose conversion factors for inhalation submersion and ingestion. Washington, DC: U.S. EPA; Federal Guidance Report No. 11; 1988.
10. Ejnik EJ, Carmichael AJ, Hamilton M, McDiarmid M, Squibb K, Boyd P, Tardiff W. Determination of the isotopic composition or uranium in urine by inductively coupled plasma mass spectrometry. Health Phys 78:143-146; 2000.
11. Evans HJ, O'Riordan ML. Human peripheral blood lymphocytes for the analysis of chromosome aberrations in mutagen tests. Mutat Res 31:135-148; 1975.
12. Evenson DP, Darzynkiewicz Z, Melamed MR. Relation of mammalian sperm chromatin heterogeneity to fertility. Science 210:1131-1133; 1980.
13. Evenson DP, Larson Kl, Jost LK. Sperm chromatin structure assay: its clinical use for detecting sperm DNA fragmentation in male infertility and comparisons with other techniques. J Androl 23:25-43; 2002.
14. Fernald Environmental Management Project. Technical basis for internal dosimetry at the Fernald Environmental Management Project. Fernald, OH: FEMP; FEMP Pub. SD 2008; 1997.
15. Finette BA, Sullivan LM, Oneill JP, Nicklas JA, Vacek PM, Albertini RJ. Determination of HPRT mutant frequencies in t-lymphocytes from a healthy pediatric population - statistical comparison between newborn, children and adult mutant frequencies, cloning efficiency and age. Mut Res 308:223-231; 1994.
16. Hahn FF, Guillmette RA, Hoover MD. Implanted depleted uranium fragments cause soft tissue sarcomas in the muscles of rats. Environ Health Perspect 100:51-59; 2002.
17. Heaton RK, Miller S W, Taylor MJ, Grant I. Revised comprehensive norms for an expanded Halstead-Reitan Battery: demographically adjusted neuropsychological norms for African American and Caucasian adults. Professional Manual. Lutz, FL: Psychological Assessment Resources; 2004.
18. Hooper FJ, Squibb KS, Siegel EL, McPhaul K, Keogh JP. Elevated urine uranium excretion by soldiers with retained uranium shrapnel. Health Phys 77:512-519; 1999.
19. Hueper WC, Zuefle JH, Link AM, Johnson MG. Experimental studies in metal cancerigenisis II. Experimental uranium in rats. J Natl Cancer Inst 13:291-305; 1952.
20. Institute of Medicine. Gulf War and health, vol 1. Fulco CE, Liverman CT, Sox HC, eds. Washington, DC: National Academy Press; 2000.
21. International Commision on Radiological Protection. Report of the task groups on reference man. Elmsford, NY: Pergamon Press; Vol. 23; 1974.
22. Jakubowski M, Trzcinka-Ochocka M, Halatek T, Razniewska G, Szymczak W. Integrated indexes of occupational exposure as predictors of kidney dysfunction. Int J Occup Med Environ Health 15:393-399; 2002.
23. Karpas Z, Kirber A, Eliah E, Marcus P, Roiz Y, Marko R, Kol R, Brikner D, Halicz L. Uranium in urine - normalization to creatinine. Health Phys 74:86-90; 1998.
24. Kathren RL, Moore RH. Acute accidental inhalation of U: a 38-year follow-up. Health Phys 51:609-619; 1986.
25. Kathren RL, McInroy JF, Moore RH, Dietert SE. Uranium in the tissues of an occupationally exposed individual. Health Phys 57:17-21; 1989.
26. Knobel Y, Glei M, Weise A, Osswald K, Schaferhenrich A, Richter KK, Claussen U, Pool-Zobel BL. Uranyl nitrilotriacetate, a stabilized salt of uranium, is genotoxic in non-transformed human colon cells and in the human colon adenoma cell line LT97. Toxicol Sci 93:286-297; 2006.
27. Leach LJ, Maynard EA, Hodge HC, Scott JK, Yuile CL, Sylvester GE, Wilson HB. A five-year inhalation study with natural uranium dioxide (UO2) dust - I. Retention and biologic effects in monkey, dog and rat. Health Phys 18:599-612; 1970.
28. Leach LJ, Yuile CL, Hodge GC, Sylvester GE, Wilson HB. A five-year inhalation study with natural uranium dioxide (UO2) dust - II. Postexposure retention and biologic effect in the monkey, dog and rat. Health Phys 25:239-258; 1973.
29. Leggett RW. The behavior and chemical toxicity of U in the kidney: a reassessment. Health Phys 57:365-383; 1989.
30. Lin RH, Wu LJ, Lee CH, Lin-Shiau SY. Cytogenetic toxicity of uranyl nitrate in Chinese hamster ovary cells. Mutat Res 319:197-203; 1993.
31. Lucchini R, Albini E, Cortesi I, Placidi D, Bergamaschi E, Traversa F, Alessio L. Assessment of neurobehavioral performance as a function of current and cumulative occupational lead exposure. Neurotoxicol 21:805-811; 2000.
32. Maynard EA, Hodge HC. Studies of the toxicity of various uranium compounds when fed to experimental animals. In: Voegtlin IC, Hodge HC, eds. Pharmacology and toxicology of uranium compounds, National Nuclear Energy Series (VI). New York: McGraw-Hill; 1949: 309-376.
33. Maynard EA, Down WL, Hodge HC. Oral toxicity of uranium compounds. In: Voegtlin C, Hodge HC, eds. Pharmacology and toxicology of uranium compounds. New York: McGraw-Hill; 1953.
34. McDiarmid M, Squibb KS. Uranium and thorium. In: Bingham E, Cohrssen B, Powell C, eds. Patty's industrial hygiene and toxicology, Vol III. New York: John Wiley & Sons; 2001: 381-422.
35. McDiarmid MA, Keogh JP, Hooper FJ, McPhaul K, Squibb KS, Kane R, DiPino R, Kabat M, Kaup B, Anderson L, Hoover D, Brown L, Hamilton M, Jacobson-Kram D, Burrows B, Walsh M. Health effects of depleted uranium on exposed Gulf War veterans. Environ Res 82:168-180; 2000.
36. McDiarmid MA, Squibb K, Engelhardt S, Oliver M, Gucer P, Wilson PD, Kane R, Kabat M, Kaup B, Anderson L, Hoover D, Brown L, Jacobson-Kram D. Surveillance of depleted uranium exposed Gulf War veterans: health effects observed in an enlarged "friendly fire" cohort. J Occup Environ Med 43:991-1000; 2001.
37. McDiarmid MA, Engelhardt SM, Oliver M, Gucer P, Wilson PD, Kane R, Kabat M, Kaup B, Anderson L, Hoover D, Brown L, Handwerger B, Albertini RJ, Jacobson-Kram D, Thorne CD, Squibb KS. Health effects of depleted uranium on exposed Gulf War veterans: a 10-year follow-up. J Toxicol Environ Health Part A 67:277-296; 2004.
38. McDiarmid MA, Squibb KS, Gucer P, Engelhardt SM, Ardell SK, Albertini RJ. Genotoxic effect at the HPRT locus and in metaphase chromosomes analyzed by FISH in depleted uranium (DU) exposed Gulf War veterans. Environ Mol Mutagen 47:54; 2006.
39. Miller AC, Blakely WF, Livengood D, Whittaker T, Xu J, Ejnik JW, Hamilton MM, Parlette E, John TS, Gerstenberg HM, Hsu H. Transformation of human osteoblast cells to the tumorigenic phenotype by depleted uranium-uranyl chloride. Environ Health Perspect 106:465-471; 1998.
40. Miller AC, Stewart M, Brooks K, Shi L, Page N. Depleted uranium-catalyzed oxidative DNA damage: absence of significant alpha decay. J Inorg Biochem 91:246-252; 2002.
41. Miller AC, Brooks K, Stewart M, Anderson B, Shi L, McClain D, Page N. Genomic instability in human osteoblast cells after exposure to depleted uranium: delayed lethality and micronuclei formation. J Environ Radioact 64:247-259; 2003.
42. Mitchel REJ, Jackson JS, Heinmeiller B. Inhaled uranium ore dust and lung cancer risk in rats. Health Phys 76:145-155; 1999.
43. National Health and Nutrition Examination Survey. Second national report on human exposure to environmental chemicals. Atlanta, GA: Centers for Disease Control and Prevention; NCEH Publication No. 02-0716; 2003.
44. Papastefanou C. Depleted uranium in military conflicts and the impact on the environment. Health Phys 83:280 -282; 2002.
45. Parkhurst MA, Daxon EG, Lodde GM, Szrom F, Guilmette RA, Roszell LE, Falo GA, McKee CB. Depleted uranium aerosol doses and risks: summary of U.S. assessments. Columbus, OH: Battelle Press; 2005.
46. Pedersen-Bjergaard J, Rowley JD. The balanced and the unbalanced chromosome aberrations of acute myeloid leukemia may develop in different ways and may contribute differently to malignant transformation. Blood 83:2780-2786; 1994.
47. Pellmar TC, Fuciarelli AF, Ejnik JW, Emond C, Mottaz HM, Landauer MR. Distribution of uranium in rats implanted with depleted uranium pellets. Toxicol Sci 49:29-39; 1999.
48. Reeves DL, Levinson D, Batsinger K, Winger B, Gastaldo E. ANAM-USMC normative data. San Diego: National Cognitive Recovery Foundation; Report No. NCRF-SR-95-05; 1995.
49. Samet JM. Radon and lung cancer. J Natl Cancer Inst 81:745-757; 1989.
50. Samet JM, Pathak DR, Morgan MV, Marbury MC, Key CR, Valdivia AA. Radon progeny exposure and lung cancer risk in New Mexico U miners: a case-control study. Health Phys 56:415-421; 1989.
51. Squibb KS, McDiarmid MA. Depleted uranium exposure and health effects in Gulf War veterans. Phil Trans R Soc B 361:639-648; 2006.
52. Squibb KS, Leggett RW, McDiarmid MA. Prediction of renal concentrations of depleted uranium and radiation dose in Gulf War veterans with embedded shrapnel. Health Phys 89:267-273; 2005.
53. StataCorp. Stata statistical software. College Station, TX: Stata; 2003.
54. Statistical Products and Service Solutions. SPSS statistical software. Chicago: SPSS; 2003.
55. Stearns DM, Yazzie M, Bradley AS, Coryell VH, Shelley JT, Ashby A, Asplund CS, Lantz RC. Uranyl acetate induces hprt mutations and uranium-DNA adducts in Chinese hamster ovary EM9 cells. Mutagenesis 20:417-423; 2005.
56. Swierenga SH, Heddle JA, Sigal EA, Gilman JP, Brillinger RL, Douglas GR, Nestmann ER. Recommended protocols based on a survey of current practice in genotoxicity testing laboratories, IV. Chromosome aberration and sister-chromatid exchange in Chinese hamster ovary, V79 Chinese hamster lung and human lymphocyte cultures. Mutat Res 246:301-322; 1991.
57. Tannenbaum A. Toxicology of uranium. New York: McGraw-Hill, Inc.; 1951.
58. The Psychological Corporation. Wechsler adult intelligence scale. San Antonio, TX: The Psychological Corporation; 1997.
59. The Royal Society. The health hazards of depleted uranium munitions part I. Policy document 6/01. London, UK: The Royal Society; 2001.
60. The Royal Society. The health effects of depleted uranium munitions. Summary. Policy document 6/02. London, UK: The Royal Society; 2002.
61. Thun MJ, Baker DB, Steenland K, Smith AB, Halperin W, Berl T. Renal toxicity in uranium mill workers. Scand J Work Environ Health 11:83-90; 1985.
62. Watanabe N, Kamel S, Ohkubo A, Yamanaka N, Ojsawa S, Makino K, Tokudo K. Urinary protein as measured with a pyrogallol red-molybdate complex, manually and in a Hitachi 726 Automated Analyzer. Clin Chem 38:642-647; 1986.
63. Woolson RF. Statistical methods for the analysis of biomedical data. New York: John Wiley & Sons, Inc.; 1987.
64. World Health Organization. WHO laboratory manual for the examination of human semen and semen-cervical mucus interaction. Cambridge, UK: Cambridge University Press; 1987.
65. Yazzie M, Gamble SL, Civetello ER, Sterns DM. Uranyl acetate causes DNA single strand breaks in vitro in the presence of ascorbate (vitamin C). Chem Res Toxicol 16:524-530; 2003.
66. Zhang L, Rothman N, Wang Y, Hayes RB, Li G, Dosemeci M, Yin S, Kolachana P, Titenko-Holland N, Smith MT. Increased aneusomy and long arm deletion of chromosomes 5 and 7 in the lymphocytes of Chinese workers exposed to benzene. Carcinogenesis 9:1955-1961; 1998.
67. Zhang L, Rothman N, Wang Y, Hayes RB, Yin S, Titenko-Holland N, Dosemeci M, Wang YZ, Kolachana P, Lu W, Xi L, Li GL, Smith MT. Benzene increases aneuploidy in the lymphocytes of exposed workers: a comparison of data obtained by fluorescence in situ hybridization in interphase and metaphase cells. Environ Mol Mutagen 34:260-268; 1999.