Random mutagenesis to identify novel Helicobacter mustelae virulence factors

FEMS Immunology and Medical Microbiology

Volumn 50, Issue 2, 2007, Pages 257-263

  Cróinín, Tadhg Ó ^a,b   McCormack, Aisling ^a,b   Van Vliet, Arnoud H M ^c   Kusters, Johannes G ^c   Bourke, Billy ^a,b  

^a OUR LADY S CHILDREN S HOSPITAL   (Ireland)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Adherence; Helicobacter pathogenesis; Motility; Random mutagenesis

Indexed keywords

UREASE; VIRULENCE FACTOR;

BACTERIAL VIRULENCE; BACTERIUM IDENTIFICATION; CHEMOTAXIS; CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVITY; GENE INSERTION; GENOMICS; HELICOBACTER INFECTION; HELICOBACTER MUSTELAE; HUMAN; HUMAN CELL; MUTAGENESIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; BACTERIAL ADHESION; CELL LINE; CHEMOTAXIS; DNA, BACTERIAL; FERRETS; GENE LIBRARY; GENES, BACTERIAL; GENOME, BACTERIAL; HELICOBACTER INFECTIONS; HELICOBACTER MUSTELAE; HUMANS; LOCOMOTION; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; SEQUENCE ANALYSIS, DNA; UREASE; VIRULENCE FACTORS;

EID: 34250341810     PISSN: 09288244     EISSN: 1574695X     Source Type: Journal    
DOI: 10.1111/j.1574-695X.2006.00207.x     Document Type: Conference Paper

References (30)

1. Ando T, Xu Q, Torres M, Kusugami K, Israel DA Blaser MJ (2000) Restriction-modification system differences in Helicobacter pylori are a barrier to interstrain plasmid transfer. Mol Microbiol 37 : 1052 1065.
2. Andrutis KA, Fox JG, Schauer DB, Marini RP, Murphy JC, Yan L Solnick JV (1995) Inability of an isogenic urease-negative mutant stain of Helicobacter mustelae to colonize the ferret stomach. Infect Immun 63 : 3722 3725.
3. Bijlsma JJE, Vandenbroucke-Grauls CMJE, Phadnis SH Kusters JG (1999) Identification of virulence genes of Helicobacter pylori by random insertion mutagenesis. Infect Immun 67 : 2433 2440.
4. Clyne M Drumm B (1993) Adherence of Helicobacter pylori to primary human gastrointestinal cells. Infect Immun 61 : 4051 4057.
5. Clyne M, Croínín TÓ, Suerbaum S, Josenhans C Drumm B (2000) Adherence of isogenic flagellum-negative mutants of Helicobacter pylori and Helicobacter mustelae to human and ferret gastric epithelial cells. Infect Immun 68 : 4335 4339.
6. Croínín TÓ, Clyne M Drumm B (1998) Molecular mimicry of ferret gastric epithelial blood group antigen A by Helicobacter mustelae. Gastroenterology 114 : 690 696.
7. Croínín TÓ, Clyne M, Appelmelk BJ Drumm B (2001) Antigastric autoantibodies in ferrets naturally infected with Helicobacter mustelae. Infect Immun 69 : 2708 2713.
8. de Jonge R, Bakker D, van Vliet AHM, Kuipers EJ, Vandenbroucke-Grauls CMJE Kusters JG (2003) Direct random insertion mutagenesis of Helicobacter pylori. J Microbiol Methods 52 : 93 100.
9. Dubois A, Fiala N, Heman-Ackah LM, Drazek ES, Tarnawski A, Fishbein WN, Perez-Perez GI Blaser MJ (1994) Natural gastric infection with Helicobacter pylori in monkeys: a model for spiral bacteria infection in humans. Gastroenterology 106 : 1405 1417.
10. Dunn BE, Sung CC, Taylor NS Fox JG (1991) Purification and characterization of Helicobacter mustelae urease. Infect Immun 59 : 3343 3345.
11. Dytoc M, Gold B, Louie M, Huesca M, Fedorko L, Crowe S, Lingwood C, Brunton J Sherman P (1993) Comparison of Helicobacter pylori and attaching-effacing Escherichia coli adhesion to eukaryotic cells. Infect Immun 61 : 448 456.
12. Fox JG, Edrise BM, Cabot EB, Beaucage C, Murphy JC Prostak KS (1986) Campylobacter-like organisms isolated from gastric mucosa of ferrets. Am J Vet Res 47 : 236 239.
13. Fox JG, Correa P, Taylor NS, Lee A, Otto G, Murphy JC Rose R (1990) Helicobacter mustelae-associated gastritis in ferrets. An animal model of Helicobacter pylori gastritis in humans. Gastroenterology 99 : 352 361.
14. Fox JG, Dangler CA, Sager W, Borkowski R Gliatto JM (1997) Helicobacter mustelae-associated gastric adenocarcinoma in ferrets (Mustela putorius furo). Vet Pathol 34 : 225 229.
15. Foynes S, Dorrell N, Ward SJ, Zhang ZW, McColm AA, Farthing MJ Wren BW (1999) Functional analysis of the roles of FliQ and FlhB in flagellar expression in Helicobacter pylori. FEMS Microbiol Lett 174 : 33 39.
16. Krakowka S, Morgan DR, Kraft WG Leunk RD (1987) Establishment of gastric Campylobacter pylori infection in the neonatal gnotobiotic piglet. Infect Immun 55 : 2789 2796.
17. Kusters JG, van Vliet AHM Kuipers EJ (2006) Pathogenesis of Helicobacter pylori infection. Clin Microbiol Rev 19 : 449 490.
18. Lee A, O'Rourke J, De Ungria MC, Robertson B, Daskalopoulos G Dixon MF (1997) A standardized mouse model of Helicobacter pylori infection: introducing the Sydney strain. Gastroenterology 112 : 1386 1397.
19. Nakamura H, Yoshiyama H, Takeuchi H, Mizote T, Okita K Nakazawa T (1998) Urease plays an important role in the chemotactic motility of Helicobacter pylori in a viscous environment. Infect Immun 66 : 4832 4837.
20. O'Rourke JL Lee A (2003) Animal models of Helicobacter pylori infection and disease. Microbes Infect 5 : 741 748.
21. O'Rourke J, Lee A Fox JG (1992) An ultrastructural study of Helicobacter mustelae and evidence of a specific association with gastric mucosa. J Med Microbiol 36 : 420 427.
22. Patterson MM, O'Toole PW, Forester NT, Noonan B, Trust TJ, Xu S, Taylor NS, Marini RP, Ihrig MM Fox JG (2003) Failure of surface ring mutant strains of Helicobacter mustelae to persistently infect the ferret stomach. Infect Immun 71 : 2350 2355.
23. Sambrook J, Fritsch EF Maniatis T (1989) Molecular Cloning, a Laboratory Manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
24. Sharetzsky C, Edlind TD, LiPuma JJ Stull TL (1991) A novel approach to insertional mutagenesis of Haemophilus influenzae. J Bacteriol 173 : 1561 1564.
25. Solnick JV, Josenhans C, Suerbaum S, Tompkins LS Labigne A (1995) Construction and characterization of an isogenic urease-negative mutant of Helicobacter mustelae. Infect Immun 63 : 3718 3721.
26. Suerbaum S, Josenhans C Labigne A (1993) Cloning and genetic characterization of the Helicobacter pylori and Helicobacter mustelae flaB flagellin genes and construction of H. pylori flaA- and flaB-negative mutants by electroporation-mediated allelic exchange. J Bacteriol 175 : 3278 3288.
27. Tsuda M, Karita M, Morshed MG, Okita K Nakazawa T (1994) A urease-negative mutant of Helicobacter pylori constructed by allelic exchange mutagenesis lacks the ability to colonize the nude mouse stomach. Infect Immun 62 : 3586 3589.
28. van Vliet AHM, Wooldridge KG Ketley JM (1998) Iron-responsive gene regulation in a Campylobacter jejuni fur mutant. J Bacteriol 180 : 5291 5298.
29. Yokota K, Kurebayashi Y, Takayama Y, Hayashi S, Isogai H, Isogai E, Imai K, Yabana T, Yachi A Oguma K (1991) Colonization of Helicobacter pylori in the gastric mucosa of Mongolian gerbils. Microbiol Immunol 35 : 475 480.
30. Yoshiyama H Nakazawa T (2000) Unique mechanism of Helicobacter pylori for colonizing the gastric mucus. Microbes Infect 2 : 55 60.