Evaluation of antifungal and DNA-damaging activities of alkaloids from branches of Porcelia macrocarpa

Planta Medica

Volumn 73, Issue 3, 2007, Pages 292-295

  Lago, João Henrique G ^a   Chaves, Mariana H ^b   Ayres, Mariane Cruz C ^b   Agripino, Débora G ^c   Young, Maria Cláudia M ^c  

^a MACKENZIE PRESBYTERIAN UNIVERSITY   (Brazil)

^b FEDERAL UNIVERSITY OF PIAUÍ   (Brazil)

^c Instituto de Pesquisas Ambientais do Estado de São Paulo   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

6 METHOXYCLEISTOPHOLINE; 6 METHOXYONYCHINE; 6,7 DIMETHOXYONYCHINE; 7 METHOXYONYCHINE; ALKALOID DERIVATIVE; APORPHINE; APORPHINE DERIVATIVE; AZAFLUORENONE; AZANTRAQUINONE; CLEISTOPHOLINE; DICHLOROMETHANE; MICONAZOLE; NYSTATIN; OXOAPORPHINE; TETRAHYDROBENZYLISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; DNA DAMAGE; DRUG ISOLATION; DRUG STRUCTURE; FRACTIONATION; NONHUMAN; THIN LAYER CHROMATOGRAPHY;

ALKALOIDS; ANNONACEAE; ANTIFUNGAL AGENTS; CLADOSPORIUM; DNA DAMAGE; HUMANS; MICROBIAL SENSITIVITY TESTS; PHYTOTHERAPY; PLANT COMPONENTS, AERIAL; PLANT EXTRACTS; SACCHAROMYCES CEREVISIAE;

CLADOSPORIUM CLADOSPORIOIDES; FUNGI; PORCELIA MACROCARPA; SACCHAROMYCES CEREVISIAE;

EID: 34250340130     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-967108     Document Type: Article

References (20)

1. 13C NMR spectroscopy. Phytochemistry 1997; 44: 523-8.
2. Brochini CB, Nuñez CV, Moreira IC, Roque NF, Chaves MH, Martins D. Identificação de componentes de óleos voláteis: análise espectroscópica de misturas de sesquiterpenos. Quim Nova 1999; 22: 37-40.
3. Chaves MH, Lago JHG, Roque NF. Macrocarpane, a new sesquiterpene skeleton from the leaves of Porcelia macrocarpa. J Braz Chem Soc 2003; 14: 16-9.
4. Chaves MH, Roque NF. Amides and lignanamides from Porcelia macrocarpa. Phytochemistry 1997; 46: 879-81.
5. Chaves MH, Freitas A, Roque NF, Cavalheiro AJ. Separação e identificação de constituintes químicos polares dos galhos de Porcelia macrocarpa. Quim Nova 2000; 23: 307-9.
6. Chaves MH, Santos LA, Lago JHG, Roque NF. Alkaloids from Porcelia macrocarpa. J Nat Prod 2001; 64: 240-2.
7. Chaves MH, Roque NF, Ayres MCC. Steroids and flavonoids of Porcelia macrocarpa. J Braz Chem Soc 2004; 15: 608-13.
8. Danelutte AP, Lago JHG, Young MCM, Kato MJ. Antifungal prenylated hydroquinones and flavanones from Piper crassinervium. Phytochemistry 2003; 64: 555-9.
9. Lago JHG, Ramos CS, Casanova DCC, Morandin AA, Bergamo DCB, Bolzani V da S et al. Benzoic acid derivatives from Piper species and their fungitoxic potential against Cladosporium cladosporioides and Cladosporium sphaerospermum. J Nat Prod 2004; 49: 1783-8.
10. Homans AL, Fuchs A. A direct bioautography on thin layer chromatograms as a method for detecting fungitoxic substances. J Chromatogr 1970; 51: 327-9.
11. Rahalison L, Hamburger M, Monod M, Frenk E, Hostettmann K. Antifungal tests in phytochemical investigations - comparison of bioautographic methods using phytopatogenic and human pathogenic fungi. Planta Med 1994; 60: 41-4.
12. Silva RV, Navickiene HMD, Kato MJ, Bolzani V da S, Méda C, Young MCM et al. Antifungal amides from Piper arboreum and Piper tuberculatum. Phytochemistry 2002; 59: 521-7.
13. Rex JH, Pfaller MA, Walsh TJ, Chaturvedi V, Espinel-Ingroff A, Ghannoum MA et al. Antifungal susceptibility testing: practical aspects current challenges. Clin Microbiol Rev 2001; 14: 643-58.
14. Gunatilaka AAL, Kingston DGI, Johnson RK. Mechanism-based isolation and structures of some anticancer active natural products. Pure Appl Chem 1994; 66: 2219-22.
15. Bolzani V da S, Gunatilaka AAL, Kingston DGI. Bioactive and other bioactive alkaloids from Cassia leptophylla. Tetrahedron 1995; 51: 5929-34.
16. Woo SH, Sun NJ, Cassady JM, Snapka RM. Inhibition of topoisomerase II by liriodenine. Biochem Pharmacol 1997; 54: 467-73.
17. Woo SH, Sun NJ, Cassady JM, Snapka RM. Topoisomerase II inhibition by aphorphine alkaloids. Biochem Pharmacol 1999; 57: 1141-5.
18. Bracher F. Polycyclic aromatic alkaloids 10. Annonaceous alkaloids with antifungal activity. Arch Pharm 1994; 327: 371-5.
19. Peterson JR, Zjawidny KJ, Liu S, Hufford CD, Clark AM, Rogers RD. Copyrine alkaloids: synthesis, spectroscopic characterization, and antimycotic/amtimycobacterial activity of A- and B-ring-functionalized sampangines. J Med Chem 1992; 35: 4069-77.
20. Hufford CD, Liu S, Clark AM. Anticandidal activity of eupolauridine and onycine, alkaloids from Cleistopholis patens. J Nat Prod 1987; 50: 961-4.