Diagnostic clues to megaloblastic anaemia without macrocytosis

International Journal of Laboratory Hematology

Volumn 29, Issue 3, 2007, Pages 163-171

  Chan, C W J ^a   Liu, S Y H ^a   Kho, C S B ^a   Lau, K H T ^a   Liang, Y S ^a   Chu, W R ^a   Ma, S K E ^b  

^a PAMELA YOUDE NETHERSOLE EASTERN HOSPITAL   (Hong Kong)

^b HONG KONG SANATORIUM AND HOSPITAL   (Hong Kong)

Author keywords

Megaloblastic anaemia; Without macrocytosis

Indexed keywords

BILIRUBIN; CYANOCOBALAMIN; FOLIC ACID; HEMOGLOBIN; IRON;

ADULT; AGED; ANAMNESIS; ARTICLE; BILIRUBIN BLOOD LEVEL; BLOOD SMEAR; BONE MARROW; CELLULAR DISTRIBUTION; CHINESE; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL DECISION MAKING; CLINICAL FEATURE; CLINICAL INDICATOR; COMPARATIVE STUDY; CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DIAGNOSTIC PROCEDURE; ERYTHROCYTE; FEMALE; FOLIC ACID DEFICIENCY; HEMATOLOGICAL PARAMETERS; HUMAN; IRON DEFICIENCY; LABORATORY TEST; MALE; MEAN CORPUSCULAR VOLUME; MEDICAL INFORMATION; MEGALOBLASTIC ANEMIA; MEGALOCYTOSIS; PRIORITY JOURNAL; RACE; RETICULOCYTE; STATISTICAL SIGNIFICANCE; THALASSEMIA; THROMBOCYTE COUNT;

AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; ANEMIA, MACROCYTIC; ANEMIA, MEGALOBLASTIC; ANEMIA, PERNICIOUS; AUTOANALYSIS; BLOOD CELL COUNT; CHRONIC DISEASE; DIAGNOSIS, DIFFERENTIAL; ERYTHROCYTE INDICES; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTGASTRECTOMY SYNDROMES; THALASSEMIA; VITAMIN B 12 DEFICIENCY;

EID: 34250324323     PISSN: 17515521     EISSN: 1751553X     Source Type: Journal    
DOI: 10.1111/j.1751-553X.2007.00911.x     Document Type: Article

References (18)

1. Au W.Y., Hui C.H., Chan L.C., Liang R.H.S. Kwong Y.L. (1998) Clinicopathological features of megaloblastic anaemia in Hong Kong: a study of 84 Chinese patients. Clinical Laboratory Haematology 20, 217 219.
2. Bertero M.T. Caligaris-Cappio F. (1997) Anemia of chronic disorders in systemic autoimmune diseases. Haematology 82, 375 381.
3. Bessman J.D., Gilmer P.R. Gardner F.H. (1983) Improved classification of anemias by MCV and RDW. American Journal of Clinical Pathology 80, 322 326.
4. Carmel R. Cassileth P.A. (1999) A focused approach to anemia. Hospital Practice 34, 71 91.
5. Carmel R., Weiner J.M. Johnson C.S. (1987) Iron deficiency occurs frequently in patients with pernicious anemia. Journal of the American Medical Association 257, 1081 1083.
6. Chan J.C.W., Liu H.S.Y., Kho B.C.S., Sim J.P.Y., Lau T.K.H., Luk Y.W., Chu R.W., Cheung F.M.F., Choi F.P.T. Ma E.S.K. (2006) Pernicious anemia in Chinese - a study of 181 patients in a Hong Kong hospital. Medicine 85, 129 135.
7. Green R., Kuhl W., Jacobson R., Johnson C., Carmel R. Beutler E. (1982) Masking of macrocytosis by α-thalassemia in blacks with pernicious anemia. New England Journal of Medicine 307, 1322 1325.
8. Guralnik J.M., Ershler W.B., Schrier S.L. Picozzi V.J. (2005) Anemia in the elderly: a public health crisis in hematology. American Society of Hematology Education Program Book 528 532.
9. Hillman R.S. Finch C.A. (1996) Red Cell Manual, 7th edn. FA Davis Company, Philadelphia, PA.
10. Kurnick J.E., Ward H.P. Pickett J.C. (1972) Mechanism of the anemia of chronic disorders: correlation of hematocrit value with albumin, vitamin B12, transferrin and iron stores. Archives of Internal Medicine 130, 323 326.
11. Lau Y.L., Chan L.C., Chan Y.Y.A., Ha S.Y., Yeung C.Y., Waye J.S. Chui D.H.K. (1997) Prevalence and genotypes of α- and β-thalassemia carriers in Hong Kong - implications for population screening. New England Journal of Medicine 336, 1298 1301.
12. Lee C.A. Fielding J. (1975) Combined dietary vitamin B12 deficiency and beta-thalassaemia trait. Lancet 2, 127 128.
13. Lindenhaum J. Nath B.J. (1980) Megaloblastic anaemia and neutrophil hypersegmentation. British Journal of Haematology 44, 511 513.
14. Lu S.-Y. Wu H.-C. (2004) Initail diagnosis of anemia from sore mouth and improved classification of anemias by MCV and RDW in 30 patients. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontics 98, 679 685.
15. Prentice A.G. Evans L.L. (1979) Megaloblastic anaemia with normal mean cell volume. Lancet 1, 606 607.
16. Spivak J.L. (1982) Masked megaloblastic anemia. Archives of Internal Medicine 142, 2111 2114.
17. Wickramasinghe S.N. (2006) Diagnosis of megaloblastic anaemias. Blood Reviews 20, 229 318.
18. You J.Y., Chen C.C., Lin E.K. Ho C.H. (2002) The characteristics of megaloblastic anemia associated with thalassemia. Haematologica 87, 550 551.