Targeted disruption of the murine large nuclear KIAA1440/Ints1 protein causes growth arrest in early blastocyst stage embryos and eventual apoptotic cell death

Biochimica et Biophysica Acta - Molecular Cell Research

Volumn 1773, Issue 7, 2007, Pages 1039-1051

  Hata, Toshiyuki ^a   Nakayama, Manabu ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b KAZUSA DNA RESEARCH INSTITUTE   (Japan)

Author keywords

Apoptosis; Embryonic lethality; Integrator complex subunit 1; Knockout mice; Large nuclear protein; snRNA processing

Indexed keywords

BETA CATENIN; CASPASE 3; CASPASE 7; INTEGRATOR COMPLEX SUBUNIT 1; PROTEIN DERIVATIVE; PROTEIN KIAA1440; SMALL NUCLEAR RNA; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ANIMAL EMBRYO; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLASTOCYST; CELL DEATH; CONTROLLED STUDY; FEMALE; GROWTH DISORDER; HETEROZYGOTE; IN VITRO STUDY; INNER CELL MASS; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; MORULA; MOUSE; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA TRANSCRIPTION; WILD TYPE;

ANIMALS; APOPTOSIS; BLASTOCYST; CELL SURVIVAL; EMBRYO CULTURE TECHNIQUES; FEMALE; GENE TARGETING; HUMANS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; PROTEIN SUBUNITS;

MURINAE; MUS;

EID: 34250223423     PISSN: 01674889     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbamcr.2007.04.010     Document Type: Article

References (29)

1. Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., and Tabata S. Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. DNA Res. 1 (1994) 27-35
2. Nagase T., Kikuno R., and Ohara O. Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. DNA Res. 8 (2001) 319-327
3. Kikuno R., Nagase T., Nakayama M., Koga H., Okazaki N., Nakajima D., and Ohara O. HUGE: a database for human KIAA proteins, a 2004 update integrating HUGEppi and ROUGE. Nucleic Acids Res. 32 (2004) D502-D504
4. Nakayama M., Kikuno R., and Ohara O. Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. Genome Res. 12 (2002) 1773-1784
5. Nakayama M., Iida M., Koseki H., and Ohara O. A gene-targeting approach for functional characterization of KIAA genes encoding extremely large proteins. FASEB J. 20 (2006) 1718-1720
6. Nakayama M., Nakajima D., Yoshimura R., Endo Y., and Ohara O. MEGF1/fat2 proteins containing extraordinarily large extracellular domains are localized to thin parallel fibers of cerebellar granule cells. Mol. Cell. Neurosci. 20 (2002) 563-578
7. Larue L., Ohsugi M., Hirchenhain J., and Kemler R. E-cadherin null mutant embryos fail to form a trophectoderm epithelium. Proc. Natl. Acad. Sci. U. S. A. 91 (1994) 8263-8267
8. Riethmacher D., Brinkmann V., and Birchmeier C. A targeted mutation in the mouse E-cadherin gene results in defective preimplantation development. Proc. Natl. Acad. Sci. U. S. A. 92 (1995) 855-859
9. Aberle H., Schwartz H., and Kemler R. Cadherin-catenin complex: protein interactions and their implications for cadherin function. J. Cell. Biochem. 61 (1996) 514-523
10. Kidd V.J. Proteolytic activities that mediate apoptosis. Annu. Rev. Physiol. 60 (1998) 533-573
11. Flach G., Johnson M.H., Braude P.R., Taylor R.A., and Bolton V.N. The transition from maternal to embryonic control in the 2-cell mouse embryo. EMBO J. 1 (1982) 681-686
12. Latham K.E. Mechanisms and control of embryonic genome activation in mammalian embryos. Int. Rev. Cyt. 193 (1999) 71-124
13. Baillat D., Hakimi M.A., Naar A.M., Shilatifard A., Cooch N., and Shiekhattar R. Integrator, a multiprotein mediator of small nuclear RNA processing, associates with the C-terminal repeat of RNA polymerase II. Cell 123 (2005) 265-276
14. Nagase T., Kikuno R., Ishikawa K.I., Hirosawa M., and Ohara O. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7 (2000) 65-73
15. Cuello P., Boyd D.C., Dye M.J., Proudfoot N.J., and Murphy S. Transcription of the human U2 snRNA genes continues beyond the 3′ box in vivo. EMBO J. 18 (1999) 2867-2877
16. Nazar R.N. Ribosomal RNA processing and ribosome biogenesis in eukaryotes. IUBMB Life 56 (2004) 457-465
17. Joyner A.L. Gene targeting, A practical approach, Second Edition. In: Hames D. (Ed). The Practical Approach Series (2000), Oxford University Press, New York 260-271
18. Jurica M.S., and Moore M.J. Pre-mRNA splicing: awash in a sea of proteins. Mol. Cell 12 (2003) 5-14
19. Valadkhan S. snRNAs as the catalysts of pre-mRNA splicing. Curr. Opin. Chem. Biol. 9 (2005) 603-608
20. Hernandez N. Formation of the 3′ end of U1 snRNA is directed by a conserved sequence located downstream of the coding region. EMBO J. 4 (1985) 1827-1837
21. Yuo C.Y., Ares Jr. M., and Weiner A.M. Sequences required for 3′ end formation of human U2 small nuclear RNA. Cell 42 (1985) 193-202
22. Medlin J.E., Uguen P., Taylor A., Bentley D.L., and Murphy S. The C-terminal domain of pol II and a DRB-sensitive kinase are required for 3′ processing of U2 snRNA. EMBO J. 22 (2003) 925-934
23. Uguen P., and Murphy S. The 3′ ends of human pre-snRNAs are produced by RNA polymerase II CTD-dependent RNA processing. EMBO J. 22 (2003) 4544-4554
24. Jacobs E.Y., Ogiwara I., and Weiner A.M. Role of the C-terminal domain of RNA polymerase II in U2 snRNA transcription and 3′ processing. Mol. Cell. Biol. 24 (2004) 846-855
25. Wieland I., Ropke A., Stumm M., Sell C., Weidle U.H., and Wieacker P.F. Molecular characterization of the DICE1 (DDX26) tumor suppressor gene in lung carcinoma cells. Oncol. Res. 12 (2000) 491-500
26. Wieland I., Sell C., Weidle U.H., and Wieacker P. Ectopic expression of DICE1 suppresses tumor cell growth. Oncol. Rep. 12 (2004) 207-211
27. Dominski Z., Yang X.C., Purdy M., Wagner E.J., and Marzluff W.F. A CPSF-73 homologue is required for cell cycle progression but not cell growth and interacts with a protein having features of CPSF-100. Mol. Cell. Biol. 25 (2005) 1489-1500
28. Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., and Ohara O. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6 (1999) 337-345
29. Dean W.L., Seufert A.C., Schultz G.A., Prather R.S., Simerly C., Schatten G., Pilch D.R., and Marzluff W.F. The small nuclear RNAs for pre-mRNA splicing are coordinately regulated during oocyte maturation and early embryogenesis in the mouse. Development 106 (1989) 325-334