Salmonella typhimurium stimulation combined with tumour-derived heat shock proteins induces potent dendritic cell anti-tumour responses in a murine model

Clinical and Experimental Immunology

Volumn 149, Issue 1, 2007, Pages 109-116

  Shilling, D A ^a   Smith, M J ^b   Tyther, R ^b   Sheehan, D ^b   England, K ^b   Kavanagh, E G ^b   Redmond, H P ^b   Shanahan, F ^a   O'Mahony, L ^a  

^a UNIVERSITY COLLEGE CORK   (Ireland)

^b UNIVERSITY COLLEGE CORK   (Ireland)

Author keywords

Bacteria; Cancer vaccines; Dendritic cells; Heat shock proteins

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; DENDRITIC CELL VACCINE; HEAT SHOCK PROTEIN; TUMOR ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

AFFINITY CHROMATOGRAPHY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BAGG ALBINO MOUSE; BONE MARROW; CANCER INHIBITION; CLONOGENIC ASSAY; CONTROLLED STUDY; DENDRITIC CELL; DRUG POTENCY; FEMALE; KIDNEY CARCINOMA; LUNG METASTASIS; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; STATISTICAL SIGNIFICANCE; TUMOR GROWTH;

ANIMALS; ANTIGENS, NEOPLASM; CANCER VACCINES; CELL PROLIFERATION; CELLS, CULTURED; CYTOTOXICITY, IMMUNOLOGIC; DENDRITIC CELLS; FEMALE; HEAT-SHOCK PROTEINS; LUNG NEOPLASMS; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; NEOPLASM TRANSPLANTATION; SALMONELLA TYPHIMURIUM; SPLEEN;

EID: 34250218230     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2007.03393.x     Document Type: Article

References (27)

1. Zitvogel L, Tesniere A, Kroemer G. Cancer despite immunosurveillance: immunoselection and immunosubversion. Nat Rev Immunol 2006 6 : 715 27.
2. Parmiani G, Castelli C, Dalerba P et al. Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going? J Natl Cancer Inst 2002 94 : 805 18.
3. Shu S, Cochran AJ, Huang RR et al. Immune responses in the draining lymph nodes against cancer: implications for immunotherapy. Cancer Metastasis Rev 2006 25 : 233 42.
4. Riezebos-Brilman A, de Mare A, Bungener L et al. Recombinant alphaviruses as vectors for anti-tumour and anti-microbial immunotherapy. J Clin Virol 2006 35 : 233 43.
5. Kim R, Emi M, Tanabe K. Functional roles of immature dendritic cells in impaired immunity of solid tumour and their targeted strategies for provoking tumour immunity. Clin Exp Immunol 2006 146 : 189 96.
6. Mende I, Engleman EG. Breaking tolerance to tumors with dendritic cell-based immunotherapy. Ann NY Acad Sci 2005 1058 : 96 104.
7. Yasuda T, Kamigaki T, Nakamura T et al. Dendritic cell-tumor cell hybrids enhance the induction of cytotoxic T lymphocytes against murine colon cancer: a comparative analysis of antigen loading methods for the vaccination of immunotherapeutic dendritic cells. Oncol Rep 2006 16 : 1317 24.
8. Weigel BJ, Panoskaltsis-Mortari A, Diers M et al. Dendritic cells pulsed or fused with AML cellular antigen provide comparable in vivo anti-tumor protective responses. Exp Hematol 2006 34 : 1403 12.
9. Banchereau J, Palucka A. Dendritic cells as therapeutic vaccines against cancer. Nat Rev Immunol 2005 5 : 297 306.
10. Nestle FO, Farkas A, Conrad C. Dendritic cell based therapeutic vaccination against cancer. Cur Opin Immunol 2005 17 : 163 9.
11. Small EJ, Schellhammer PF, Higano CS et al. Placebo-controlled phase III trial of immunologic therapy with sipuleucel-T (APC8015) in patients with metastatic, asymptomatic hormone refractory prostate cancer. J Clin Oncol 2006 24 : 3089 94.
12. Tanaka F, Yamaguchi H, Haraguchi N et al. Efficient induction of specific cytotoxic T lymphocytes to tumor rejection peptide using functional matured 2 day-cultured dendritic cells derived from human monocytes. Int J Oncol 2006 29 : 1263 8.
13. Wu CJ, Chen LC, Kuo ML. Attenuated Salmonella typhimurium reduces ovalbumin-induced airway inflammation and T-helper type 2 responses in mice. Clin Exp Immunol 2006 145 : 116 22.
14. Ge R, Rajeev V, Ray P et al. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res 2006 12 : 4315 30.
15. Pulaski BA, Ostrand-Rosenberg S. Reduction of established spontaneous mammary carcinoma metastases following immunotherapy with major histocompatibility complex class II and B7.1 cell-based tumor vaccines. Cancer Res 1998 58 : 1486 93.
16. Menoret A, Bell G. Purification of multiple heat shock proteins from a single tumor sample. J Immunol Meth 2000 237 : 119 30.
17. Goldman B. Cancer vaccines: finding the best way to train the immune system. J Natl Cancer Inst 2002 94 : 1523 6.
18. Goetz MP, Toft DO, Ames MM et al. The Hsp90 chaperone complex as a novel target for cancer therapy. Ann Oncol 2003 14 : 1169 76.
19. Massa C, Guiducci C, Arioli I et al. Enhanced efficacy of tumor cell vaccines transfected with secretable hsp70. Cancer Res 2004 64 : 1502 8.
20. Belli F, Testori A, Rivoltini L et al. Vaccination of metastatic melanoma patients with autologous tumor-derived heat shock protein gp96-peptide complexes: clinical and immunologic findings. J Clin Oncol 2002 20 : 4169 80.
21. Paglia P, Medina E, Arioli I et al. Gene transfer in dendritic cells, induced by oral DNA vaccination with Salmonella typhimurium, results in protective immunity against a murine fibrosarcoma. Blood 1998 92 : 3172 6.
22. Cochlovius B, Stassar MJ, Schreurs MW et al. Oral DNA vaccination: antigen uptake and presentation by dendritic cells elicits protective immunity. Immunol Lett 2002 80 : 89 96.
23. Weth R, Christ O, Stevanovic S et al. Gene delivery by attenuated Salmonella typhimurium: comparing the efficacy of helper versus cytotoxic T cell priming in tumor vaccination. Cancer Gene Ther 2001 8 : 599 611.
24. Zoller M. Unexpected induction of unresponsiveness by vaccination with transformed Salmonella typhimurium. J Immunother 2002 25 : 162 75.
25. Hummel S, Apte RN, Qimron U et al. Tumor vaccination by Salmonella typhimurium after transformation with a eukaryotic expression vector in mice: impact of a Salmonella typhimurium gene interfering with MHC class I presentation. J Immunother 2005 28 : 467 79.
26. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003 3 : 133 46.
27. Kalinski P, Mailliard RB, Giermasz A et al. Natural killer-dendritic cell cross-talk in cancer immunotherapy. Expert Opin Biol Ther 2005 5 : 1303 15.