Synthetic cinnamylphenol derivatives as cancer chemopreventive agents

European Journal of Medicinal Chemistry

Volumn 42, Issue 7, 2007, Pages 902-909

  Ito, Chihiro ^a   Itoigawa, Masataka ^b   Kanematsu, Tetsufumi ^a   Imamura, Yuuki ^a   Tokuda, Harukuni ^c   Nishino, Hoyoku ^c   Furukawa, Hiroshi ^a  

^a MEIJO UNIVERSITY   (Japan)

^b TOKAI GAKUEN UNIVERSITY   (Japan)

^c KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Anti tumor promoters; Cancer chemopreventive agents; Cinnamylphenols; Epstein Barr virus activation; Two stage mouse skin carcinogenesis

Indexed keywords

2 HYDROXY 3 METHOXY 6 CINNAMYLPHENOL PRENYL ETHER; 2 METHOXY 3 PRENYLOXY 6 CINNAMYLPHENOL METHYL ETHER; 2,3 DIMETHOXY 4,6 DICINNAMYLPHENOL METHYL ETHER; 2,3 DIPRENYLOXY 6 CINNAMYLPHENOL METHYL ETHER; 2,3,4' TRIHYDROXY 3' METHOXY 6 CINNAMYLPHENOL METHYL ETHER; 2,4' DIHYDROXY 3,3' DIMETHOXY 6 CINNAMYLPHENOL; 2,4' DIHYDROXY 3,3' DIMETHOXY 6 CINNAMYLPHENOL PRENYL ETHER; 3 HYDROXY 2,6 DICINNAMYLPHENOL METHYL ETHER; 3 METHOXY 2 CINNAMYLPHENOL; 3 METHOXY 2 CINNAMYLPHENOL PRENYL ETHER; 3 METHOXY 2 PRENYLOXY 6 CINNAMYLPHENOL; 3 METHOXY 2 PRENYLOXY 6 CINNAMYLPHENOL PRENYL ETHER; 3,3' DIMETHOXY 2,4' DIPRENYLOXY 6 CINNAMYLPHENOL; 3,3' DIMETHOXY 2,4' DIPRENYLOXY 6 CINNAMYLPHENOL PRENYL ETHER; 4' ACETOXY 2 HYDROXY 3,3' DIMETHOXY 6 CINNAMYLPHENOL; 4' ACETOXY 2,3 DIHYDROXY 3' METHOXY 6 CINNAMYLPHENOL METHYL ETHER; 4' HYDROXY 3,3' DIMETHOXY 2 PRENYLOXY 6 CINNAMYLPHENOL; 5 METHOXY 2 CINNAMYLPHENOL PRENYL ETHER; 5 PRENYLOXY 2 CINNAMYLPHENOL METHYL ETHER; CINNAMIC ACID DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CANCER PREVENTION; CARCINOGENESIS; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; EPSTEIN BARR VIRUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN;

ALKENES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HERPESVIRUS 4, HUMAN; HUMANS; MICE; MOLECULAR STRUCTURE; NEOPLASMS; NEOPLASMS, EXPERIMENTAL; PHENOLS; TIME FACTORS;

EID: 34250217023     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.12.024     Document Type: Article

References (15)

1. Heller W., and Forkmann G. In: Harborne J.B. (Ed). The Flavonoids (1988), Chapman and Hall, London 399-425 Chapter 11
2. Ito C., Itoigawa M., Miyamoto Y., Rao K.S., Takayasu J., Okuda Y., Mukainaka T., Tokuda H., Nishino H., and Furukawa H. J. Nat. Prod. 62 (1999) 1668-1671
3. Itoigawa M., Ito C., Ju-ichi M., Nobukuni T., Ichiishi E., Tokuda H., Nishino H., and Furukawa H. Cancer Lett. 176 (2002) 25-29
4. Ito C., Itoigawa M., Tan H.T.W., Tokuda H., Mou X.Y., Mukainaka T., Ishikawa T., Nishino H., and Furukawa H. Cancer Lett. 152 (2000) 187-192
5. Ito C., Itoigawa M., Kanematsu T., Ruangrungsi N., Mukainaka T., Tokuda H., Nishino H., and Furukawa H. Phytochemistry 64 (2003) 1265-1268
6. Ito C., Itoigawa M., Kojima N., Tokuda H., Hirata T., Nishino H., and Furukawa H. J. Nat. Prod. 67 (2004) 1125-1130
7. Ito C., Itoigawa M., Kanematsu T., Ruangrungsi N., Higashihara H., Tokuda H., Nishino H., and Furukawa H. J. Nat. Prod. 66 (2003) 1574-1577
8. Goda Y., Kiuchi F., Shibuya M., and Sankawa U. Chem. Pharm. Bull. 40 (1992) 2452-2457
9. Zanarotti A. Tetrahedron Lett. 23 (1982) 3963-3964
10. Huang M.-T., Ma W., Lu Y.-P., Chang R.L., Fisher C., Manchand P.S., Newmark H.L., and Conney A.H. Carcinogenesis 16 (1995) 2493-2497
11. Ishida J., Kozuka M., Wang H.-K., Konoshima T., Tokuda H., Okuda M., Mou X.Y., Nishino H., Sakurai N., Lee K.-H., and Nagai M. Cancer Lett. 159 (2000) 135-140
12. Mageswaran S., Ollis W.D., Roberts R.J., and Sutherland I.O. Tetrahedron Lett. 34 (1969) 2897-2900
13. Goda Y., Katayama M., Ichikawa K., Shibuya M., Kiuchi F., and Sankawa U. Chem. Pharm. Bull. 33 (1985) 5606-5609
14. Kurosawa K., Ollis W.D., Sutherland I.O., Gottlieb O.R., and Oliveira A.B. Phytochemistry 17 (1978) 1389-1394
15. Achenbach H., Stocker M., and Constenla M.A. Phytochemistry 27 (1988) 1835-1841