Genotoxicity study of illegal drug MDMA and its nitroso derivative N-MDMA by micronucleus and chromosomal aberration tests using Chinese hamster lung fibroblast cell line

Environmental Health and Preventive Medicine

Volumn 12, Issue 3, 2007, Pages 129-137

  Yoshioka, Hayato ^a   Shimizu, Hidesuke ^a   Toyama, Yoshimitsu ^a,b   Miyakoshi, Yuichi ^a   Suzuki, Yuji ^a   Takagi, Ryo ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JAPAN   (Japan)

Author keywords

Chromosomal aberration test; Genotoxicity; MDMA; Micronucleus test; N MDMA

Indexed keywords

3,4 METHYLENEDIOXYMETHAMPHETAMINE; ILLICIT DRUG; N NITROSO 3,4 METHYLENEDIOXYMETHAMPHETAMINE; NITROSO DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CHINESE HAMSTER; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CONTROLLED STUDY; GENOTOXICITY; IN VITRO STUDY; LABORATORY TEST; LUNG FIBROBLAST; MICRONUCLEUS; MICRONUCLEUS TEST; NONHUMAN;

CRICETULUS GRISEUS;

EID: 34250205268     PISSN: 1342078X     EISSN: 13474715     Source Type: Journal    
DOI: 10.1265/ehpm.12.129     Document Type: Article

References (34)

1. NIDA-NIH-U.S. Department of Health & Human Services. MDMA (Ecstasy): NIDA INFO FACTS, March. 2005. p. 1-3.
2. National Police Agency, Government of Japan. White Paper on Police 2006. 2006. p. 158-165. (Article in Japanese)
3. World Health Organization. Expert Committee on Drug Dependence. Twenty-Second Report. 1985. p. 24-25.
4. Makino Y, Tanaka S, Kurobane S, Nakauchi M, Terasaki T, Ohta S. Profiling of illegal amphetamine-type stimulant tablets in Japan. J Health Science. 2003;49:129-137.
5. Cami J, Farre M, Mas M. Human pharmacology of 3,4- methylenedioxymethamphetamine ("Ecstasy"): psychomotor performance and subjective effects. J Clin Psychopharmac. 2000;20:455-466.
6. Nishimura Y. Recent abuse of 3,4-methylenedioxymethamphetamine ("Yaoto-wang", "Ecstasy"). Seishin Shinkeigaku Zasshi. 2002;104:819-833. (Article in Japanese)
7. Johanlyn L, Jean LC. Methylenedioxymethamphetamine (MDMA, Ecstasy) neurotoxicity: cellular and molecular mechanisms. Brain Res Review. 2003;42:155-168.
8. Morton J. Ecstasy: pharmacology and neurotoxicity. Curr Opin Pharmacol. 2005;5:79-86.
9. Druckrey H, Preussumann R, Ivankovic S, Schmahl D, Afkham J, Blum G, et al. Organotrope carcinogene Wirkungen bei 65 verschiedenen N-Nitroso- Verbindungen an BD-Ratten. Z Krebsforschung. 1967;69:103-201.
10. Cardesa A, Pour P, Althoff J, Mohr U. Vascular tumors in female mice after intraperitoneal injection of dimethylnitrosamine. JNCI. 1973;51:201-208.
11. Magee PN, Barnes JM. The production of malignant primary hepatic tumors in the rat by feeding dimethylnitrosamine. Br J Cancer. 1956;10:114-122.
12. Toth B, Magee PN, Shubik P. Carcinogenesis study with dimethyl-nitrosamine administered orally to adult and subcutaneously to new born BALB/C mice. Cancer Res. 1964;24:1712-1721.
13. Heddle LA, Hite M, Kierkhart B, Mavourin K, MacGregor JT, Newell GW, et al. The induction of micronuclei as a measure of genotoxicity: a report of the US Environmental Protection Agency Gene-Tox Program. Mutat Res. 1983;123:61-118.
14. Sofuni T (Ed). Data Book of Chromosomal Aberration Test in Vitro. Life-science Information Center; 1998. (Article in Japanese)
15. Ishidate M Jr., Odashima S. Chromosome test with 134 compounds on Chinese hamster cell in vitro - a screening for chemical carcinogens. Mutat Res. 1977;48:337-354.
16. Ando H, Morita M. Possibility of in vitro and in vivo formations of N-nitrosomethamphetamine. Reports of National Research Institute of Police Science. 1983;36:16-20. (Article in Japanese)
17. Ames BN, McCann J, Yamasaki E. Method for detecting carcinogens and mutagens with the Salmonella/mammalian-microsome mutagenicity test. Mutat Res. 1975;31:347-364.
18. Matsuoka A, Hayashi M, Ishidate M Jr. Chromosomal aberration tests on 29 chemicals combined with S9mix in vitro. Mutat Res. 1979;66:277-290.
19. Toyama Y, Shimizu H, Suzuki Y, Miyakoshi Y, Yoshioka H. Genotoxic effects of N-nitrosoketamine and ketamine as assessed by in vitro micronucleus test in Chinese hamster lung fibroblast cell line. Environ Health Prev Med. 2006;11:120-127.
20. Li J, Suzuki Y, Shimizu H, Fukumoto M, Okonogi H, Nagashima T, et al. In vitro micronucleus assay of 30 chemicals in CHL cells. Jikeikai Med J. 1993;40:69-83.
21. Matsushima T, Hayashi M, Matsuoka A, Ishidate M, Miura KF, Shimizu H, et al. Validation study of the in vitro micronucleus test in a Chinese hamster lung cell line (CHL/IU). Mutagenesis. 1999;14:569-580.
22. Japanese Ministry of Health and Welfare. Guidelines for Toxicity Studies of Drugs. 1999.
23. Scott D, Galloway SM, Marshall RR, Ishidate M Jr., Brusick D, Ashby J, et al. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9. Mutat Res. 1991;257:147-205.
24. Cochran WG. Some methods for strengthening the common 2 tests. Biometrics. 1954;10:417-451.
25. Armitage P. Test for linear trends in proportions and frequencies. Biometrics. 1955;11: 375-386.
26. Savage JRK. Classification and relationship of induced chromosomal structural changes. J Med Genet. 1976;13:103-122.
27. Ishidate M Jr., Sofuni T, Yoshikawa K. Chromosomal aberration tests in vitro as a primary screening tool for environmental mutagenes and/or carcinogens. GANN Monograph on Cancer Research. 1981;27:95-108.
28. Sasaki MS. Chromosome Aberration Formation and Sister Chromatid Exchange in Relation to DNA Repair in Human Cells. Plenum Press; 1980. p. 285-314.
29. Duncan AMV, Heddle JA, Blakey DH. Mechanism of induction of nuclear anomalies by γ-radiation in the colonic epithelium of the mouse. Cancer Res. 1985;45:250-252.
30. Tjalve H. The tissue distribution and the tissue specificity of bioactivation of some tobacco-specific and some other N-nitrosamines. Crit Rev Toxicol. 1991;21:265-294.
31. Araki A, Muramatsu M, Matsushima T. Comparison of mutagenicities of N-nitrosamines on salmonella typhimurium TA 100 and Escherichia coli WP2 UVRA/PKM101 using rat and hamster liver S9. Gann. 1984;75:8-16.
32. Raineri R, Poliey JA, Andrews AW, Pienta RJ, Lijinsky W. Greater effectiveness of hepatocyte and liver S9 preparations from hamsters than rat preparations in activating N-nitroso compounds to metabolites mutagenic to salmonella. JNCI. 1981;67:1117-1122.
33. Shimizu H, Takemura N, Ando H, Morita M, Machida K. Mutagenic activity of N-nitrosomethamphetamine and N-nitrosoephedrine. Cancer Lett. 1983;21:63-68.
34. McElhatton PR, Bateman DN, Evans C, Pughe KR, Thomas SHL. Congential anomalies after prenatal ecstasy exposure. Lancet. 1999;354:1441-1442.