The candidate gene approach to susceptibility for abdominal aortic aneurysm: TIMP1, HLA-DR-15, ferritin light chain, and collagen XI-alpha-1

Annals of the New York Academy of Sciences

Volumn 1085, Issue , 2006, Pages 282-290

  Tilson III, M David ^a,b   Ro, Charles Y ^a  

^a ST LUKE S ROOSEVELT HOSPITAL CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

Abdominal aortic aneurysm; Autoimmunity; Candidate genes; COL11A1; Collagen XI; Ferritin light chain; Genome wide screening; HLA DR; Matrix metalloproteinases; Matrix remodeling; Oxidative injury; Protease inhibitors; Susceptibility genes; TIMP

Indexed keywords

COLLAGEN TYPE 11; COLLAGEN TYPE 11 ALPHA 1; FERRITIN; FERRITIN LIGHT CHAIN; HLA DR15 ANTIGEN; TISSUE INHIBITOR OF METALLOPROTEINASE 1; UNCLASSIFIED DRUG; COLLAGEN; HLA DR ANTIGEN; HLA DR15; HLA-DR15;

ABDOMINAL AORTA ANEURYSM; CONFERENCE PAPER; DNA POLYMORPHISM; FUNDING; GENE MUTATION; GENETIC SCREENING; GENETIC SUSCEPTIBILITY; GENOME ANALYSIS; HUMAN; LABORATORY TEST; NUCLEOTIDE SEQUENCE; PATHOLOGY; POPULATION RESEARCH; CLASSIFICATION; GENETIC PREDISPOSITION; GENETICS; REVIEW;

AORTIC ANEURYSM, ABDOMINAL; COLLAGEN; FERRITINS; GENETIC PREDISPOSITION TO DISEASE; HLA-DR ANTIGENS; HUMANS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 34250189128     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1383.016     Document Type: Conference Paper

References (31)

1. TILSON, M.D. & H.C. STANSEL. 1980. Differences in results for aneurysm vs. occlusive disease after bifurcation grafts: results of 100 elective grafts. Arch. Surg. 115: 1173-1175.
2. TILSON, M.D. 1982. Decreased hepatic copper levels. A possible chemical marker for the pathogenesis of aortic aneurysms in man. Arch. Surg. 117: 1212-1213.
3. BLANCHARD, J.F. 1999. Epidemiology of abdominal aortic aneurysms. Epidemiol. Rev. 21: 207-221.
4. JAAKKOLA, P., M. HIPPELAINEN & M. KANTOLA. 1994. Copper and zinc concentrations of abdominal aorta and liver in patients with infrarenal abdominal aortic aneurysm or aortoiliacal occlusive disease. Ann. Chir. Gynaecol. 83: 304-308.
5. TILSON, M.D. & G. DAVIS. 1983. Deficiencies of copper and a compound with ionexchange characteristics of pyridinoline in skin from patients with abdominal aortic aneurysms. Surgery 94: 134-141.
6. TILSON, M.D., R.N. DREYER, A. HUDSON, et al. 1985. Partial characteristics of an analog of pyridinoline isolated from human skin. Biochem. Biophys. Res. Commun. 126: 1222-1227.
7. TILSON, M.D. 1985. Further studies of a putative cross-linking amino acid (3-deoxypyridinoline) in skin from patients with abdominal aortic aneurysms. Surgery 98: 888-891.
8. TILSON, M.D., J.M. REILLY, C.M. BROPHY, et al. 1993. Expression and sequence of the gene for tissue inhibitor of metalloproteinases in patients with abdominal aortic aneurysms. J. Vasc. Surg. 18: 266-270.
9. WANG, X., G. TROMP, C.W. COLE, et al. 1999. Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms. Matrix Biol. 18: 121-124.
10. IRIZARRY, E., K.M. NEWMAN, R.H. GANDHI, et al. 1993. Demonstration of interstitial collagenase in abdominal aortic aneurysm disease. J. Surg. Res. 54: 571-574.
11. JEAN-CLAUDE, J., K.M. NEWMAN, H. LI, et al. 1994. Possible key role for plasmin in the pathogenesis of abdominal aortic aneurysms. Surgery 116: 472-478.
12. K.M. NEWMAN, Y. OGATA, A.M. MALON, et al. 1994. Identification of matrix metalloproteinases 3 (stromelysin-1) and 9 (gelatinase B) in abdominal aortic aneurysm. Arterioscler. Thromb. 14: 1315-1320.
13. NEWMAN, K.M., A.M. MALON, R.D. SHIN, et al. 1994. Matrix metalloproteinases in abdominal aortic aneurysm: characterization, purification, and their possible sources. Connect. Tissue Res. 30: 265-276.
14. TILSON, M.D. & K.M. NEWMAN. 1994. Proteolytic mechanisms in the pathogenesis of aortic aneurysms. In Aneurysms: new findings and treatments. Yao, J.S. & W.H. Pearce, Eds.: 3-9. Appleton and Lange. Norwalk CT.
15. GREGORY, A.K., N.X. YIN, J. CAPELLA, et al. 1996. Features of autoimmunity in the abdominal aortic aneurysm. Arch. Surg. 131: 85-88.
16. TILSON, M.D., K.J. OZSVATH, H. HIROSE & S. XIA. 1996. A genetic basis for autoimmune manifestations in the abdominal aortic aneurysm resides in the MHC class II locus DR-beta-1. Ann. N.Y.Acad. Sci. 800: 208-215.
17. HIROSE, H., M. TAKAGI, N. MIYAGAWA, et al. 1998. Genetic risk factor for abdominal aortic aneurysm: HLA-DR2(15), a Japanese study. J. Vasc. Surg. 27: 500-503.
18. HIROSE H. & M.D. TILSON. 1999. Negative genetic risk factor for abdominal aortic aneurysm: HLA-DQ3, a Japanese study. J. Vasc. Surg. 30: 959-960.
19. JORDAN, T.P. BA, X.G. LI, J.C. OBUNIKE & M.D. TILSON. 2002. Aneurysmal diseases cosegregate in an African-American kindred with HLA class II DR-B1-15. International College of Angiology. New York.
20. RASMUSSEN, T.E., J.W. HALLETT, JR., S. SCHULTE, et al. 2001. Genetic similarity in inflammatory and degenerative abdominal aortic aneurysms: a study of human leukocyte antigen class II disease risk genes. J. Vasc. Surg. 34: 84-89.
21. LI, X., J. OBUNIKE & M.D. TILSON. 2002. Ferritin-like expressed mRNA with two substitutions changing putative expressed protein, from aortic aneurysm adventitial fibroblasts (bases 1-900). In GenBank Accession # AY207005.
22. TILSON, M.D. F.C., S.X. XIA, D. SYN, et al. 2000. Expression of molecular messages for angiogenesis by fibroblasts from aneurysmal abdominal aorta versus dermal fibroblasts. Int. J. Surg. Invest. 1: 453-457.
23. PAIK D. & M.D. TILSON. 1996. Neovascularization in the abdominal aortic aneurysm. Endothelial nitric oxide synthase, nitric oxide, and elastolysis. Ann. N. Y. Acad. Sci. 800: 277.
24. PAIK, D.C., W.G. RAMEY, J. DILLON & M.D. TILSON. 1997. The nitrite/elastin reaction: implications for in vivo degenerative effects. Connect. Tissue Res. 36: 241-251.
25. MILLER, F.J., JR., W.J. SHARP, X. FANG, et al. 2002. Oxidative stress in human abdominal aortic aneurysms: a potential mediator of aneurysmal remodeling. Arterioscler. Thromb. Vasc. Biol. 22: 560-565.
26. YAJIMA, N., M. MASUDA, M. MIYAZAKI, et al. 2002. Oxidative stress is involved in the development of experimental abdominal aortic aneurysm: a study of the transcription profile with complementary DNA microarray. J. Vasc. Surg. 36: 379-385.
27. SHIBAMURA, H., J.M. OLSON, C. VAN VLIJMEN-VAN KEULEN, et al. 2004. Genome scan for familial abdominal aortic aneurysm using sex and family history as covariates suggests genetic heterogeneity and identifies linkage to chromosome 19q13. Circulation 109: 2103-2108.
28. BHATTI, A. E.D., T.P. JORDAN, T.A. MCCAFFREY, et al. 2002. Role of collagen type XI in the pathogenesis of the abdominal aortic aneurysm. J. Am. Coll. Surg. 195 (Suppl):S201.
29. BELSLEY S.J. & M.D. TILSON. 2003. Two decades of research on etiology and genetic factors in abdominal aortic aneurysm disease. (Review Article) Acta Chir. Belg. 103: 187-197.
30. KUIVANIEMI H. & T. OGATA. 2006. Highlights of the recent literature on abdominal aortic aneurysm research. (Editorial) Ann. Vasc. Surg. 20: 1-4.
31. TILSON M.D., III. 2005. The polymorphonuclear leukocyte and the abdominal aortic aneurysm: a neglected cell type and a neglected disease. (Editorial) Circulation 112: 154-156.