Assessment of bleeding after concomitant administration of antiplatelet and anticoagulant agents in lower limb arthroplasty

Pathophysiology of Haemostasis and Thrombosis

Volumn 35, Issue 6, 2006, Pages 428-434

  Dahl, Ola E ^a   Ögren, Mats ^e   Agnelli, Giancarlo ^c   Eriksson, Bengt I ^d   Cohen, Alexander T ^b   Mouret, Patrick ^f   Rosencher, Nadia ^g   Bylock, Anders ^e   Panfilov, Seva ^e   Andersson, Magnus ^e  

^a THROMBOSIS RESEARCH INSTITUTE   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF PERUGIA   (Italy)

^d QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^e ASTRAZENECA R AND D   (Sweden)

^f Frankfurt Höchst City Hospital   (Germany)

^g Cochin Hospital ^*  (France)

Author keywords

Arthroplasty; Aspirin; Bleeding; NSAID; Thromboprophylaxis; Total hip replacement; Total knee replacement

Indexed keywords

ACETYLSALICYLIC ACID; ENOXAPARIN; MELAGATRAN; NONSTEROID ANTIINFLAMMATORY AGENT; XIMELAGATRAN;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTHROPLASTY; ARTICLE; BLEEDING; BLOOD TRANSFUSION; COMPARATIVE STUDY; CONTROLLED STUDY; FEMALE; HUMAN; LEG; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE CARE; PREOPERATIVE CARE; PRIORITY JOURNAL; THROMBOSIS;

ADULT; AGED; AGED, 80 AND OVER; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTICOAGULANTS; ARTHROPLASTY; ASPIRIN; AZETIDINES; BENZYLAMINES; BLEEDING TIME; BLOOD LOSS, SURGICAL; BLOOD TRANSFUSION; DOUBLE-BLIND METHOD; ENOXAPARIN; EUROPE; FEMALE; HUMANS; LOWER EXTREMITY; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; SOUTH AFRICA; THROMBOSIS;

EID: 34250185337     PISSN: 14248832     EISSN: None     Source Type: Journal    
DOI: 10.1159/000102049     Document Type: Article

References (11)

1. Felson D: Clinical practice. Osteoarthritis of the knee. N Engl J Med 2006;354:841-848.
2. Geerts WH, Pineo GF, Heit JA, Bergqvist D, Lassen MR, Colwell CW, Ray JG: Prevention of venous thromboembolism: the seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest 2004;126:338S-400S.
3. Robinson CM, Christie J, Malcolm-Smith N: Nonsteroidal antiinflammatory drugs, perioperative blood loss, and transfusion requirements in elective hip arthroplasty. J Arthroplasty 1993;8:607-610.
4. Slappendel R, Weber EW, Benraad B, Dirksen R, Bugter ML: Does ibuprofen increase perioperative blood loss during hip arthroplasty? Eur J Anaesthesiol 2002;19:829-831.
5. Fischer HB, Simanski CJ: A procedure-specific systematic review and consensus recommendations for analgesia after total hip replacement. Anaesthesia 2005;60:1189-1202.
6. Macie C, Forbes L, Foster GA, Douketis JD: Dosing practices and risk factors for bleeding in patients receiving enoxaparin for the treatment of an acute coronary syndrome. Chest 2004;125:1616-1621.
7. Eriksson BI, Agnelli G, Cohen AT, Dahl OE, Mouret P, Rosencher N, Eskilson C, Nylander I, Frison L, Ogren M: Direct thrombin inhibitor melagatran followed by oral ximelagatran in comparison with enoxaparin for prevention of venous thromboembolism after total hip or knee replacement. Thromb Haemost 2003;89:288-296.
8. Dahl O, Eriksson BI, Agnelli G, Cohen A, Mouret P, Rosencher N, Panfilov S, Bylock A, Andersson M: Postoperative melagatran/ximelagatran for the prevention of venous thromboembolism following major elective orthopaedic surgery: effects of timing of first dose and risk factors for thromboembolism and bleeding complications on efficacy and safety. Clin Drug Invest 2005;25:65-77.
9. Rosencher N, Kerkkamp HE, Macheras G, Munuera LM, Menichella G, Barton DM, Cremers S, Abraham IL, Investigation O: Orthopedic Surgery Transfusion Hemoglobin European Overview (OSTHEO) Study: blood management in elective knee and hip arthroplasty in Europe. Transfusion 2003;43:459-469.
10. Eriksson BI, Agnelli G, Cohen A, Dahl O, Mouret P, Rosencher N, Panfilov S, Andersson M: Significantly lower need for blood transfusions associated with post-operatively initiated subcutaneous melagatran/oral ximelagatran compared with enoxaparin. Thromb Haemost 2004;92:428-430.
11. AstraZeneca Press Release: 14th February 2006. http://www.astrazeneca. com/pressrelease/5217.aspx