Stability of a heparin-free 50% ethanol lock solution for central venous catheters

Journal of Oncology Pharmacy Practice

Volumn 13, Issue 1, 2007, Pages 33-37

  Pomplun, Maria ^a   Johnson, Jeremy J ^b   Johnston, Susan ^c   Kolesar, Jill M ^a  

^a UNIVERSITY OF WISCONSIN   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c University of Wisconsin Health   (United States)

Author keywords

Catheter; Ethanol; Infection; Lock; Stability

Indexed keywords

ALCOHOL; ANTIBIOTIC AGENT; DISINFECTANT AGENT; HEPARIN;

ARTICLE; CANCER CENTER; CENTRAL VENOUS CATHETER; COLUMN CHROMATOGRAPHY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFICACY; DRUG STABILITY; DRUG STORAGE; GAS CHROMATOGRAPHY; PRIORITY JOURNAL; ROOM TEMPERATURE; SYRINGE; UNITED STATES;

ANTI-INFECTIVE AGENTS, LOCAL; CATHETERIZATION, CENTRAL VENOUS; CHROMATOGRAPHY, GAS; DRUG COMPOUNDING; DRUG PACKAGING; DRUG STABILITY; DRUG STORAGE; ETHANOL; FLAME IONIZATION; SOLUTIONS; SYRINGES;

EID: 34250183126     PISSN: 10781552     EISSN: None     Source Type: Journal    
DOI: 10.1177/1078155207077598     Document Type: Article

References (14)

1. Moro ML, Vigano EF, Cozzi Lepri A. Risk factors for central venous catheter-related infections in surgical and intensive care units. The central venous catheter-related infections study group. Infect Control Hosp Epidemiol 1994; 15: 253-64.
2. Egebo K, Toft P, Jakobsen CJ. Contamination of central venous catheters. The skin insertion wound is a major source of contamination. J Hosp Infect 1996; 32: 99-104.
3. Ingram LO, Buttke TM. Effects of alcohols on microorganisms. Adv Microb Physiol 1984; 25: 253-300.
4. Sissons CH, Wong L, Cutress TW. Inhibition by ethanol of the growth of biofilm and dispersed microcosm dental plaques. Arch Oral Biol 1996; 41: 27-34.
5. Dannenberg C, Bierbach U. Rothe A, Beer J, Korholz D. Ethanol-lock technique in the treatment of bloodstream infections in pediatric oncology patients with broviac catheter. J Pediatr Hematol Oncol 2003; 25: 616-21.
6. Metcalf SC, Chambers ST, Pithie AD. Use of ethanol locks to prevent recurrent central line sepsis. J Infect 2004; 49: 20-22.
7. Ball PA, Brokenshire E, Parry B, Merrie A, Gillanders L, McIlroy K, Plank L. Ethanol locking as a possible treatment for microbial contamination of long-term central venous catheters. Nutrition 2003; 19: 570.
8. Laird J, Soutar R, Butcher I. Complications of the ethanol-lock technique in the treatment of central venous catheter sepsis. J Infect 2005; 51: 338.
9. Crnich CJ, Halfmann JA, Crone WC, Maki DG. The effects of prolonged ethanol exposure on the mechanical properties of polyurethane and silicone catheters used for intravascular access. Infect Control Hosp Epidemiol 2005; 26: 708-14.
10. Lambda NMK, Woodhouse KA, Cooper SL. Polyurethanes in Biomedical Applications 1998; 1st edn, New York: CRC Press, 1998.
11. Neale ME. Rapid high-performance liquid chromatography method for determination of ethanol and fusel oil in the alcoholic beverage industry. J Chromatogr 1988; 447: 443-50.
12. Kristoffersen L, Stormyhr LE, Smith-Kielland A. Headspace gas chromatographic determination of ethanol: The use of factorial design to study effects of blood storage and headspace conditions on ethanol stability and acetaldehyde formation in whole blood and plasma. Forensic Sci Int 2006; 161: 151-57.
13. Kayikcioglu O, Akkin C. Alcohol liberates dye of syringes. Int Ophthalmol 1996; 20: 291-92.
14. Guenu S, Heng AE, Charbonne F, Galmier MJ, Charles F, Deteix P, Souweine B, Latrigue C. Mass spectrometry and scanning electron microscopy study of silicone tunneled dialysis catheter integrity after an exposure of 15 days to 60% ethanol solution. Rapid Commun Mass Spectrom 2006; 21: 229-36.