Deprotonation and regioselective addition of 2H-pyrazolo[3,4-c]quinolines to electrophiles

Journal of Organic Chemistry

Volumn 72, Issue 12, 2007, Pages 4570-4573

  Danielson, Michael E ^a,b   Hays, David S ^a   Kshirsagar, Tushar A ^a   Haraldson, Chad A ^a   Lundquist, Gregory D ^a   Wurst, Joshua R ^a   Lindstrom, Kyle J ^a   Mackey, Sonja S ^a   Willie, Daniel J ^a   Heppner, Philip D ^a   Leir, Charles M ^a   Benson, Karl E ^a  

^a 3M COMPANY   (United States)

^b Biothera   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZALDEHYDE; ELECTROPHILES; QUINOLINES;

ALDEHYDES; CARBON DIOXIDE; DEPROTONATION; IODINE; REGIOSELECTIVITY;

NITROGEN COMPOUNDS;

2H PYRAZOLO[3,4 C]QUINOLINE DERIVATIVE; BENZALDEHYDE; CARBON DIOXIDE; IODINE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; PROTON TRANSPORT;

BENZALDEHYDES; CARBON DIOXIDE; DIMETHYLFORMAMIDE; IODINE; PYRAZOLES; QUINOLINES;

EID: 34250173066     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo070392t     Document Type: Article

References (14)

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10. Data not shown.
11. (Chemical Equation Presented)
12. An excess of n-butyl lithium was used to ensure reproducible bis-deprotonation.
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14. CMA refers to a 80:18:2 ratio of chloroform/MeOH/concentrated aqueous ammonium hydroxide.