Fetal myelomeningocele repair: Urologic aspects

Current Opinion in Urology

Volumn 17, Issue 4, 2007, Pages 257-262

  Carr, Michael C ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Fetal surgery; Myelomeningocele; Urodynamics

Indexed keywords

BIOMETRY; FETUS SURGERY; HUMAN; LEG; MENINGOMYELOCELE; MOTOR PERFORMANCE; NERVE CELL DIFFERENTIATION; PRIORITY JOURNAL; REVIEW; SPINA BIFIDA; URODYNAMICS; UROLOGIC EXAMINATION;

FEMALE; FETAL DISEASES; FETOSCOPY; HUMANS; MENINGOMYELOCELE; PREGNANCY; TREATMENT OUTCOME; URODYNAMICS;

EID: 34250160216     PISSN: 09630643     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOU.0b013e3281ddb2f1     Document Type: Review

References (13)

1. Couzin J. New focus, desperate measures. Science 2006; 313:904-907. This article summarizes the issues with fetal surgery, including ongoing trials, and provides a good prospective for the issue.
2. Bergman J, Konijeti R, Lerman S. Myelomeningocele information on the Internet is accessible and of variable quality, and requires a high reading level. J Urol 2007; 177:1138-1142. The Internet has become the major source of information for the public at large as well as those in the medical field. This article summarizes what is available on the Internet relating to myelomeningocele and points out the high level of reading function that is necessary to understand this information.
3. Heffez DS, Aryanpur J, Hutchins GM, Freeman JM. The paralysis associated with myelomeningocele: clinical and experimental data implicating a preventable spinal cord injury. Neurosurgery 1990; 26:987-992.
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6. Holzbeierlein J, Pope JC IV, Adams MC, et al. The urodynamic profile of myelodysplasia in childhood with spinal closure during gestation. J Urol 2000; 164:1336-1339.
7. Holmes NM, Nguyen HT, Harrison MR, et al. Fetal intervention for myelomeningocele: effect on postnatal bladder function. J Urol 2001; 166:2383-2386.
8. Koh CJ, DeFilippo RE, Borer JG, et al. Bladder and external urethral sphincter function after prenatal closure of myelomeningocele. J Urol 2006; 176:2232-2236.
9. Rintoul NE, Sutton LN, Hubbard AM, et al. A new look at myelomeningocele's functional level, vertebral level, shunting and implications for fetal intervention. Pediatrics 2002; 109:409-413.
10. Johnson MP, Gerdes M, Rintoul N, et al. Maternal-fetal surgery for myelomeningocele: neurodevelopmental outcomes at 2 years of age. Am J Obstet Gynec 2006; 194:1145-1152. This preliminary information from the Children's Hospital of Philadelphia assesses neurodevelopmental outcome in a cohort of patients who have undergone fetal repair of their myelomeningocele. This is the first such study to provide an early assessment of outcome but underscores the need for longer-term follow-up data.
11. McLone DG, Krepper PA. The cause of Chiari II malformation: a unified theory. Pediatr Neurosci 1989; 15:1-12.
12. Danzer E, Johnson MP, Bebbington M, et al. Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair. Fetal Diagn Ther 2007; 22:1-5. Ultrasonography has been the mainstay in assessing prenatal issues. The MRI study provides additional information that may provide further insights following in-utero repair of myelomeningocele. These radiographic findings then will also need to be correlated with functional outcome data.
13. Carr MC. Urologic update of patients who had undergone fetal repair of their myelomeningocele. J Pediatr Urol 2006; 2:87-89.