Effects of glucosamine sulfate on intracellular UDP-hexosamine and UDP-glucuronic acid levels in bovine primary chondrocytes

Osteoarthritis and Cartilage

Volumn 15, Issue 7, 2007, Pages 773-779

  Qu, C J ^a   Jauhiainen, M ^a   Auriola, S ^a   Helminen, H J ^a   Lammi, M J ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Glucosamine sulfate; Osteoarthritis; Proteoglycan; UDP sugar

Indexed keywords

AGGRECAN; GLUCOSAMINE; GLUCOSAMINE SULFATE; GLUCOSE; GLUCURONIC ACID; GLYCOSAMINOGLYCAN; HEXOSAMINE; MESSENGER RNA; SULFATE; SULFUR 35; URIDINE DIPHOSPHATE;

ANIMAL CELL; ARTICLE; CARBOHYDRATE ANALYSIS; CARTILAGE CELL; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; COW; ELECTROSPRAY MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; RNA EXTRACTION;

ANIMALS; CATTLE; CHONDROCYTES; GLUCOSAMINE; GLUCOSE; GLUCURONIC ACID; HEXOSAMINES; OSTEOARTHRITIS; URIDINE DIPHOSPHATE SUGARS;

EID: 34250023991     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2007.01.010     Document Type: Article

References (27)

1. Reginster J.Y., Deroisy R., Rovati L.C., Lee R.L., Lejeune E., Bruyere O., et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet 357 (2001) 251-256
2. Pavelka K., Gatterova J., Olejarova M., Machacek S., Giacovelli G., and Rovati L.C. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 162 (2002) 2113-2123
3. Pavelka K., Bruyere O., Rovati L.C., Olejarova M., Giacovelli G., and Reginster J.Y. Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials. Osteoarthritis Cartilage 11 (2003) 730-737
4. Richy F., Bruyere O., Ethgen O., Cucherat M., Henrotin Y., and Reginster J.Y. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med 163 (2003) 1514-1522
5. Bruyere O., Pavelka K., Rovati L.C., Deroisy R., Olejarova M., Gatterova J., et al. Glucosamine sulfate reduces osteoarthritis progression in postmenopausal women with knee osteoarthritis: evidence from two 3-year studies. Menopause 11 (2004) 138-143
6. Rindone J.P., Hiller D., Collacott E., Nordhaugen N., and Arriola G. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 172 (2000) 91-94
7. Hughes R., and Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology 41 (2002) 279-284
8. McAlindon T., Formica M., LaValley M., Lehmer M., and Kabbara K. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med 117 (2004) 643-649
9. Cibere J., Kopec J.A., Thorne A., Singer J., Canvin J., Robinson D.B., et al. Randomized, double-blind, placebo-controlled glucosamine discontinuation trial in knee osteoarthritis. Arthritis Rheum 51 (2004) 738-745
10. Clegg D.O., Reda D.J., Harris C.L., Klein M.A., O'Dell J.R., Hooper M.M., et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354 (2006) 795-808
11. Setnikar I., Pacini M.A., and Revel L. Antiarthritic effects of glucosamine sulfate studied in animal models. Arzneimittelforschung 41 (1991) 542-545
12. Bassleer C.T., Combal J.P., Bougaret S., and Malaise M. Effects of chondroitin sulfate and interleukin-1 beta on human articular chondrocytes cultivated in clusters. Osteoarthritis Cartilage 6 (1998) 196-204
13. Ilic M.Z., Martinac B., and Handley C.J. Effects of long-term exposure to glucosamine and mannosamine on aggrecan degradation in articular cartilage. Osteoarthritis Cartilage 11 (2003) 613-622
14. Hua J., Sakamoto K., and Nagaoka I. Inhibitory actions of glucosamine, a therapeutic agent for osteoarthritis, on the functions of neutrophils. J Leukoc Biol 71 (2002) 632-640
15. Biggee B.A., Blinn C.M., McAlindon T.E., Nuite M., and Silbert J.E. Low levels of human serum glucosamine after ingestion of glucosamine sulphate relative to capability for peripheral effectiveness. Ann Rheum Dis 65 (2006) 222-226
16. Marshall S., Nadeau O., and Yamasaki K. Dynamic actions of glucose and glucosamine on hexosamine biosynthesis in isolated adipocytes: differential effects on glucosamine 6-phosphate, UDP-N-acetylglucosamine, and ATP levels. J Biol Chem 279 (2004) 35313-35319
17. 35S-sulphate incorporation in bovine primary chondrocytes. Biochim Biophys Acta 1762 (2006) 453-459
18. McAlindon T.E., and Biggee B.A. Nutritional factors and osteoarthritis: recent developments. Curr Opin Rheumatol 17 (2005) 647-652
19. 14C] glucosamine to the rat. Pharmatherapeutica 3 (1984) 538-550
20. Setnikar I., Giacchetti C., and Zanolo G. Pharmacokinetics of glucosamine in the dog and in man. Arzneimittelforschung 36 (1986) 729-735
21. Bassleer C., Rovati L., and Franchimont P. Stimulation of proteoglycan production by glucosamine sulfate in chondrocytes isolated from human osteoarthritic articular cartilage in vitro. Osteoarthritis Cartilage 6 (1998) 427-434
22. Bassleer C., Gysen P., Bassleer R., and Franchimont P. Effects of peptidic glycosaminoglycans complex on human chondrocytes cultivated in three dimensions. Biochem Pharmacol 37 (1988) 1939-1945
23. Dodge G.R., and Jimenez S.A. Glucosamine sulfate modulates the levels of aggrecan and matrix metalloproteinase-3 synthesized by cultured human osteoarthritis articular chondrocytes. Osteoarthritis Cartilage 11 (2003) 424-432
24. Piperno M., Reboul P., Hellio Le Graverand M.P., Peschard M.J., Annefeld M., Richard M., et al. Glucosamine sulfate modulates dysregulated activities of human osteoarthritic chondrocytes in vitro. Osteoarthritis Cartilage 8 (2000) 207-212
25. 3H]chondroitin sulphate formation by cultured chondrocytes. Biochem J 376 (2003) 511-515
26. 35S-sulfate with cultured human chondrocytes to determine the effect of glucosamine concentration on formation of chondroitin sulfate. Arthritis Rheum 50 (2004) 3574-3579
27. 3H]glucosamine by endogenous hexosamine from glucose and other sources. Arch Biochem Biophys 268 (1989) 393-397