The effect of gentamicin sulphate on the fracture properties of a manually mixed bone cement

Fatigue and Fracture of Engineering Materials and Structures

Volumn 30, Issue 6, 2007, Pages 479-488

  Baleani, M ^a   Persson, C ^a   Guandalini, L ^a   Piazza, E ^a   Erani, P ^a   Squarzoni, S ^b   Viceconti, M ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

^b CNR   (Italy)

Author keywords

Biomaterials; Fatigue crack propagation; Fracture morphology; Fracture toughness; Mechanical properties

Indexed keywords

ANTIBIOTICS; FATIGUE CRACK PROPAGATION; FRACTURE; FRACTURE TOUGHNESS; STRESS INTENSITY FACTORS;

BARIUM SULPHATE; GENTAMICIN SULPHATE; POLYMETHYLMETHACRYLATE-BASED CEMENT; RADIOPACIFYING AGENT;

BONE CEMENT;

EID: 34250015819     PISSN: 8756758X     EISSN: 14602695     Source Type: Journal    
DOI: 10.1111/j.1460-2695.2007.01109.x     Document Type: Article

References (31)

1. Hendriks, J. G., van Horn, J. R., van der Mei, H. C. and Busscher, H. J. (2004). Backgrounds of antibiotic-loaded bone cement and prosthesis-related infection. Biomaterials, 25, 545-556.
2. Buchholz, H. W. and Engelbrecht, H. (1970). Über die Deporwirkunf einiger Antibiotika bei Vermischung mit dem Kunzhartz Palacos. Der Chirurg; Zeitschrift für alle Gebiete der Operativen Medize, 41, 511-515.
3. Lindberg, L., Onnerfalt, R., Dingeldein, E. and Wahlig, H. (1991). The release of gentamicin after total hip replacement using low or high viscosity bone cement. A prospective, randomized study. Int Orthop, 15, 305-309.
4. Davies, J. P., O'Connor, D. O., Burke, D. W. and Harris, W. H. (1989). Influence of antibiotic impregnation on the fatigue life of Simplex P and Palacos R acrylic bone cements, with and without centrifugation. J Biomed Mater Res., 23, 379-397.
5. Rimnac, C. M., Wright, T. M. and McGill, D. L. (1986). The effect of centrifugation on the fracture properties of acrylic bone cements. J Bone Joint Surg [Am], 68, 281-287.
6. Wright, T. M., Sullivan, D. J. and Arnoczky, S. P. (1984). The effect of antibiotic additions on the fracture properties of bone cements. Acta Orthop Scand, 55, 414-418.
7. Schurman, D. J., Swenson, L. and Piziali, R. L. (1978). Bone cement with and without antibiotics: A study of mechanical properties. In: The Hip. Proceedings of the sixth open scientific meeting of the Hip Society (Edited by Mosby), St. Louis, pp. 87-96.
8. Owen, A. B. and Beaumont, P. W. (1979). Fracture behaviour of commercial surgical acrylic bone cements. J Biomed Eng, 1, 277-280.
9. Armstrong, M. S., Spencer, R. F., Cunningham, J. L., Gheduzzi, S., Miles, A. W. and Learmonth, I. D. (2002). Mechanical characteristics of antibiotic-laden bone cement. Acta Orthop Scand, 73, 688-690.
10. Lewis, G., Janna, S. and Bhattaram, A. (2005). Influence of the method of blending an antibiotic powder with an acrylic bone cement powder on physical, mechanical, and thermal properties of the cured cement. Biomaterials, 26, 4317-4325.
11. Baleani, M., Cristofolini, L., Minari, C. and Toni, A. (2003). Fatigue strength of PMMA bone cement mixed with gentamicin and barium sulphate vs pure PMMA. Proc Inst Mech Eng [H], 217, 9-12.
12. Torrado, S., Frutos, P. and Frutos, G. (2001). Gentamicin bone cements: characterisation and release (in vitro and in vivo assays). Int J Pharm, 217, 57-69.
13. Frutos, P., Diez-Pena, E., Frutos, G. and Barrales-Rienda, J. M. (2002). Release of gentamicin sulphate from a modified commercial bone cement. Effect of (2-hydroxyethyl methacrylate) comonomer and poly(N-vinyl-2-pyrrolidone) additive on release mechanism and kinetics. Biomaterials, 23, 3787-3797.
14. Hendriks, J. G., Neut, D., Hazenberg, J. G., Verkerke, G. J., van Horn, J. R., van der Mei, H. C. and Busscher, H. J. (2005). The influence of cyclic loading on gentamicin release from acrylic bone cements. J Biomech, 38, 953-957.
15. Lewis, G. and Janna, S. (2004). The in vitro elution of gentamicin sulfate from a commercially available gentamicin-loaded acrylic bone cement, VersaBond AB. J Biomed Mater Res (Appl Biomater), 71, 77-83.
16. Jasty, M., Maloney, W. J., Bragdon, C. R., O'Connor, D. O., Haire, T. and Harris, W. H. (1991). The initiation of failure in cemented femoral components of hip arthroplasties. J Bone Joint Surg [Br], 73, 551-558.
17. Topoleski, L. D., Ducheyne, P. and Cuckler, J. M. (1990). A fractographic analysis of in vivo poly(methyl methacrylate) bone cement failure mechanisms. J Biomed Mater Res., 24, 135-154.
18. McCormack, B. A. O. and Prendergast, P. J. (1999). Microdamage accumulation in the cement layer of hip replacements under flexural loading. J Biomech, 32, 467-475.
19. McCormack, B. A. O., Prendergast, P. J. and O'Dwyer, B. (1999). Fatigue of cemented hip replacements under torsional loads. Fatigue Fract Engng Mater Struct, 22, 33-40.
20. Lewis, G. (2003). Fatigue testing and performance of acrylic bone-cement materials: State-of-the-art review. J Biomed Mater Res (Appl Biomater), 66, 457-486.
21. Nguyen, N. C., Maloney, W. J. and Dauskardt, R. H. (1997). Reliability of PMMA bone cement fixation: Fracture and fatigue crack-growth behaviour. J Mater Sci Mater Med, 8, 473-483.
22. Freitag, T. A. and Cannon, S. L. (1977). Fracture characteristics of acrylic bone cements. II. Fatigue. J Biomed Mater Res., 11, 609-624.
23. Vila, M. M., Ginebra, M. P., Gil, F. J. and Planell, J. A. (1999). Effect of porosity and environment on the mechanical behavior of acrylic bone cement modified with acrylonitrile-butadiene-styrene particles: part II. Fatigue crack propagation. J Biomed Mater Res., 48, 128-134.
24. Lewis, G. and Janna, S. (2003). Effect of test specimen cross-sectional shape on the in vitro fatigue life of acrylic bone cement. Biomaterials, 24, 4315-4321.
25. Cristofolini, L., Minari, C. and Viceconti, M. (2000). A methodology and criterion for acrylic bone cement fatigue tests. Fatigue Fract Engng Mater Struct, 23, 953-957.
26. Collins, J. A. (1993). Failure of materials in mechanical design. John Wiley & Sons, Columbus.
27. Molino, L. M. and Topoleski, L. D. T. (1996). Effect of BaSO4 on the fatigue crack propagation rate of PMMA bone cement. J Biomed Mater Res., 31, 131-137.
28. Liaw, P. K., Logsdon, W. A., Roth, L. D. and Hartmann, H.-R. (1985). Krak-Gages for Automated Fatigue Crack Growth Rate Testing: A Review. Automated Test Methods for Fracture and Fatigue Crack Growth, ASTM STP 877, 177-196.
29. Armitage, P. and Berry, G. (1994). Statistical methods in medical research. Blackwell, Oxford.
30. Guandalini, L., Baleani, M. and Viceconti, M. (2004). A procedure and criterion for bone cement fracture toughness tests. Proc Inst Mech Eng [H], 218, 445-450.
31. Topoleski, L. D. T., Ducheyne, P. and Cuckler, J. M. (1993). Microstructural pathway of fracture in poly(methyl methacrylate) bone cement. Biomaterials, 14, 1165-1172.