Levels of abnormal prion protein in deer and elk with chronic wasting disease

Emerging Infectious Diseases

Volumn 13, Issue 6, 2007, Pages 824-830

  Race, Brent L ^a   Meade White, Kimberly D ^a   Ward, Anne ^a   Jewell, Jean ^b   Miller, Michael W ^c   Williams, Elizabeth S ^b   Chesebro, Bruce ^a   Race, Richard E ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b UNIVERSITY OF WYOMING   (United States)

^c Colorado Division of Wildlife ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PRION PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN DISEASE; CHRONIC WASTING DISEASE; CORRELATION ANALYSIS; DEER; DISEASE TRANSMISSION; LYMPHOID TISSUE; NONHUMAN;

EID: 34250001639     PISSN: 10806040     EISSN: 10806059     Source Type: Journal    
DOI: 10.3201/eid1306.070186     Document Type: Article

References (38)

1. Caughey B, Raymond GJ, Ernst D, Race RE. N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state. J Virol. 1991;65:6597-603.
2. Prusiner SB. Molecular biology of prion diseases. Science. 1991;252:1515-22.
3. Jeffery M. In: Harris DA, editor. Mad cow disease and related spongiform encephalopathies. New York: Springer-Verlag; 2004. p. 65-98.
4. Prusiner SB. Novel proteinaceous infectious particles cause scrapie. Science. 1982;216:136-44.
5. Williams ES. Chronic wasting disease. Vet Pathol. 2005;42:530-49.
6. Miller MW, Williams ES, McCarty CW, Spraker TR, Kreeger TJ, Larsen CT, et al. Epizootiology of chronic wasting disease in free-ranging cervids in Colorado and Wyoming. J Wildl Dis. 2000;36:676-90.
7. Hadlow WJ, Kennedy RC, Race RE. Natural infection of Suffolk sheep with scrapie virus. J Infect Dis. 1982;146:657-64.
8. van Keulen LJ, Schreuder BE, Meloen RH, Mooij-Harkes G, Vromans ME, Langeveld JP. Immunohistochemical detection of prion protein in lymphoid tissues of sheep with natural scrapie. J Clin Microbiol. 1996;34:1228-31.
9. Heggebo R, Press CM, Gunnes G, Gonzalez L, Jeffrey M. Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep. J Gen Virol. 2002;83:479-89.
10. Peden AH, Ritchie DL, Head MW, Ironside JW. Detection and localization of PrPSc in the skeletal muscle of patients with variant, iatrogenic, and sporadic forms of Creutzfeldt-Jakob disease. Am J Pathol. 2006;168:927-35.
11. Eklund CM, Kennedy RC, Hadlow WJ. Pathogenesis of scrapie virus infection in the mouse. J Infect Dis. 1967;117:15-22.
12. Race RE, Ernst D. Detection of proteinase K-resistant prion protein and infectivity in mouse spleen by 2 weeks after scrapie agent inoculation. J Gen Virol. 1992;73:3319-23.
13. Slow virus diseases of animals and man. In: Kirnberi RH, editor. Frontiers of biology. Amsterdam: North-Holland Publishing Company; 1976.
14. Collee JG, Bradley R. BSE: a decade on - Part I. Lancet. 1997;349:636-41.
15. Collee JG, Bradley R. BSE: a decade on - Part 2. Lancet. 1997;349:715-21.
16. Sigurdson CJ, Williams ES, Miller MW, Spraker TR, O'Rourke KI, Hoover EA. Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus). J Gen Virol. 1999;80:2757-64.
17. Hamir AN, Gidlewski T, Spraker TR, Miller JM, Creekmore L, Crocheck M, et al. Preliminary observations of genetic susceptibility of elk (Cervus elaphus nelsoni) to chronic wasting disease by experimental oral inoculation. J Vet Diagn Invest. 2006;18:110-4.
18. Spraker TR, Balachandran A, Zhuang D, O'Rourke KI. Variable patterns of distribution of PrP(CWD) in the obex and cranial lymphoid tissues of Rocky Mountain elk (Cervus elaphus nelsoni) with subclinical chronic wasting disease. Vet Rec. 2004;155:295-302.
19. Hibler CP, Wilson KL, Spraker TR, Miller MW, Zink RR, DeBuse LL, et al. Field validation and assessment of an enzyme-linked immunosorbent assay for detecting chronic wasting disease in mule deer (Odocoileus hemionus), white-tailed deer (Odocoileus virginianus), and Rocky Mountain elk (Cervus elaphus nelsoni). J Vet Diagn Invest. 2003;15:311-9.
20. Oldstone MB, Race R, Thomas D, Lewicki H, Homann D, Smelt S, et al. Lymphotoxin-alpha- and lymphotoxin-beta-deficient mice differ in susceptibility to scrapie: evidence against dendritic cell involvement in neuroinvasion. J Virol. 2002;76:4357-63.
21. Race R, Jenny A, Sutton D. Scrapie infectivity and proteinase K-resistant prion protein in sheep placenta, brain, spleen, and lymph node: implications for transmission and antemortem diagnosis. J Infect Dis. 1998;178:949-53.
22. Race R, Raines A, Raymond GJ, Caughey B, Chesebro B. Long-term subclinical carrier state precedes scrapie replication and adaptation in a resistant species: analogies to bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease in humans. J Virol. 2001;75:10106-12.
23. Race RE, Raines A, Baron TG, Miller MW, Jenny A, Williams ES. Comparison of abnormal prion protein glycoform patterns from transmissible spongiform encephalopathy agent-infected deer, elk, sheep, and cattle. J Virol. 2002;76:12365-8.
24. Vorberg I, Buschmann A, Harmeyer S, Saalmuller A, Pfaff E, Groschup MH. A novel epitope for the specific detection of exogenous prion proteins in transgenic mice and transfected murine cell lines. Virology. 1999;255:26-31.
25. Raymond GJ, Olsen EA, Lee KS, Raymond LD, Bryant PK 3rd, Baron GS, et al. Inhibition of protease-resistant prion protein formation in a transformed deer cell line infected with chronic wasting disease. J Virol. 2006;80:596-604.
26. Kimberlin RH, Walker CA. The role of the spleen in the neuroinvasion of scrapie in mice. Virus Res. 1989;12:201-11.
27. Hill AF, Joiner S, Wadsworth JD, Sidle KC, Bell JE, Budka H, et al. Molecular classification of sporadic Creutzfeldt-Jakob disease. Brain. 2003;126:1333-46.
28. Bessen RA, Marsh RF. Biochemical and physical properties of the prion protein from two strains of the transmissible mink encephalopathy agent. J Virol. 1992;66:2096-101.
29. Goldmann W, Hunter N, Smith G, Foster J, Hope J. PrP genotypes and the Sip gene in Cheviot sheep form the basis for scrapie strain typing in sheep. Ann N Y Acad Sci. 1994;724:296-9.
30. Race R, Ernst D, Jenny A, Taylor W, Sutton D, Caughey B. Diagnostic implications of detection of proteinase K-resistant protein in spleen, lymph nodes, and brain of sheep. Am J Vet Res. 1992;53:883-9.
31. Hadlow WJ, Race RE, Kennedy RC. Temporal distribution of transmissible mink encephalopathy virus in mink inoculated subcutaneously. J Virol. 1987;61:3235-40.
32. Mathiason CK, Powers JG, Dahmes SJ, Osborn DA, Miller KV, Warren RJ, et al. Infectious prions in the saliva and blood of deer with chronic wasting disease. Science. 2006;314:133-6.
33. Belay ED, Gambetti P, Schonberger LB, Parchi P, Lyon DR, Capellari S, et al. Creutzfeldt-Jakob disease in unusually young patients who consumed venison. Arch Neurol. 2001;58:1673-8.
34. Kong Q, Huang S, Zou W, Vanegas D, Wang M, Wu D, et al. Chronic wasting disease of elk: transmissibility to humans examined by transgenic mouse models. J Neurosci. 2005;25:7944-9.
35. Tamguney G, Giles K, Bouzamondo-Bernstein E, Bosque PJ, Miller MW, Safar J, et al. Transmission of elk and deer prions to transgenic mice. J Virol. 2006;80:9104-14.
36. Cutlip RC, Miller JM, Race RE, Jenny AL, Katz JB, Lehmkuhl HD, et al. Intracerebral transmission of scrapie to cattle. J Infect Dis. 1994;169:814-20.
37. Raymond GJ, Bossers A, Raymond LD, O'Rourke KI, McHolland LE, Bryant PK 3rd, et al. Evidence of a molecular barrier limiting susceptibility of humans, cattle and sheep to chronic wasting disease. EMBO J. 2000;19:4425-30.
38. Hamir AN, Kunkle RA, Cutlip RC, Miller JM, Williams ES, Richt JA. Transmission of chronic wasting disease of mule deer to Suffolk sheep following intracerebral inoculation. J Vet Diagn Invest. 2006;18:558-65.