Pharmacokinetics of fentanyl in male and female rats after intravenous administration

Arzneimittel-Forschung/Drug Research

Volumn 57, Issue 5, 2007, Pages 260-263

  Ohtsuka, Hiroyuki ^a   Fujita, Kazuhiro ^a   Kobayashi, Hiroyuki ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

Analgesics; CAS 990 73 8; Fentanyl, pharmacokinetics, rat, sex difference

Indexed keywords

FENTANYL;

AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG HALF LIFE; FEMALE; MALE; NONHUMAN; RAT; SEX DIFFERENCE; TIME TO MAXIMUM PLASMA CONCENTRATION;

EID: 34250001105     PISSN: 00044172     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0031-1296615     Document Type: Article

References (12)

1. Maguire P, Tsai N, Kamal J, Cometta-Morini C, Upton C, Loew G. Pharmacological profiles of fentanyl analogs at μ, σ and κ opiate receptors. Eur J Pharmacol. 1992;213:219-225.
2. Mather LE. Clinical Pharmacokinetics of fentanyl and its newer derivatives. Clin Pharmacokinet. 1983;8:422-446.
3. Romagnoli A. Duration of action of fentanyl. Anesthesiology. 1973;39:568-569.
4. Björkman S, Stanski DR, Verotta D, Harashima H. Comparative tissue concentration profiles of fentanyl and alfentanil in humans predicted from tissue/blood partition data obtained in rats. Anesthesiology. 1990;72:865-873.
5. Ohtsuka H, Kobayashi H, Shigeoka T, Torii S, Shimomura H, Nemoto H, et al. Pharmacokinetics of fentanyl after intravenous and subcutaneous administration to rats and dogs [Japanese with English abstract]. Jpn Pharmacol Ther. 2001;29:855-864.
6. Hug CC Jr, Murphy MR. Tissue redistribution of fentanyl and termination of its effects in rats. Anesthesiology. 1981;55:369-375.
7. Schemmel R, Michelsen O, Mostosky U. Infuluence of body weight, age, diet and sex on fat depots in rats. Anat Rec. 1969;166:437-445.
8. Feierman DE. Identification of cytochrome P450 3A1/2 as the major P450 isoform responsible for the metabolism of fentanyl by rat liver microsomes. Anesth Analgol. 1996;82:936-941.
9. Imaoka S, Yamada T, Hiroi T, Hayashi K, Sakaki T, Yabusaki et al. Multiple forms of human P450 expressed in Saccharomyces cerevisiae. Systematic characterization and comparison with those of the rat. Biochem Pharmacol. 1996;51:1041-1050.
10. Yamazoe Y, Murayama N, Shimada M, Yamauchi K, Nagata K, Imaoka S, et al. A sex-specific form of cytochrome P-450 catalyzing propoxycoumarin O-depropylation and its identity with testosterone 6 beta-hydroxylase in untreated rat livers: reconstitution of the activity with microsomal lipids. J Biochem. 1988;104:785-790.
11. Davies B, Morris T. Physiological parameters in laboratory animals and humans. Pharm Res. 1993;10:1093-1095.
12. Ariano RE, Duke PC, Sitar DS. Population pharmacokinetics of fentanyl in healthy volunteers. J Clin Pharmacol. 2001;41:757-763.