Fluorochrome-linked immunoassay for functional analysis of the mannose binding lectin complement pathway to the level of C3 cleavage

Journal of Immunological Methods

Volumn 323, Issue 2, 2007, Pages 147-159

  Walsh, Mary C ^a   Shaffer, Lisa A ^a   Guikema, Benjamin J ^a   Body, Simon C ^a   Shernan, Stanton K ^a   Fox, Amanda A ^a   Collard, Charles D ^b   Fung, Michael ^d   Taylor, Ronald P ^c   Stahl, Gregory L ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b TEXAS HEART INSTITUTE   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d Tanox Biosystems Inc   (United States)

Author keywords

Assay; MBL; Quantification

Indexed keywords

CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT; COMPLEMENT COMPONENT C2; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C4; FICOLIN; FLUOROCHROME; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN;

ADAPTIVE IMMUNITY; ANTIGEN RECOGNITION; ARTICLE; COMPLEMENT LECTIN PATHWAY; CONTROLLED STUDY; FREEZE THAWING; GENETIC POLYMORPHISM; HAPLOTYPE; HOMOZYGOTE; HUMAN; HUMAN TISSUE; HUMORAL IMMUNITY; IMMUNOASSAY; INNATE IMMUNITY; PLASMA; PRIORITY JOURNAL; SERUM; STATISTICAL ANALYSIS;

AMINO ACID SEQUENCE; BLOOD; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; FLUORESCENT DYES; HUMANS; IMMUNOASSAY; MANNOSE-BINDING LECTINS; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MOLECULAR SEQUENCE DATA;

EID: 34249998901     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jim.2007.04.004     Document Type: Article

References (53)

1. Baccarelli A., Hou L., Chen J., Lissowska J., El-Omar E.M., Grillo P., Giacomini S.M., Yaeger M., Bernig T., Zatonski W., Fraumeni Jr. J.F., Chanock S.J., and Chow W.H. Mannose-binding lectin-2 genetic variation and stomach cancer risk. Int. J. Cancer 119 (2006) 1970
2. Bathum L., Hansen H., Teisner B., Koch C., Garred P., Rasmussen K., and Wang P. Association between combined properdin and mannose-binding lectin deficiency and infection with Neisseria meningitidis. Mol. Immunol. 43 (2006) 473
3. Bax W.A., Cluysenaer O.J., Bartelink A.K., Aerts P.C., Ezekowitz R.A., and van D.H. Association of familial deficiency of mannose-binding lectin and meningococcal disease. Lancet 354 (1999) 1094
4. Best L.G., Davidson M., North K.E., MacCluer J.W., Zhang Y., Lee E.T., Howard B.V., DeCroo S., and Ferrell R.E. Prospective analysis of mannose-binding lectin genotypes and coronary artery disease in American Indians: the strong heart study. Circulation 109 (2004) 471
5. Bouwman L.H., Eerligh P., Terpstra O.T., Daha M.R., de K.P., Ballieux B.E., Bruining G.J., Van Der Slik A.R., Roos A., and Roep B.O. Elevated levels of mannose-binding lectin at clinical manifestation of type 1 diabetes in juveniles. Diabetes 54 (2005) 3002
6. Brouwer N., Dolman K.M., van Z.R., Nieuwenhuys E., Hart M., Aarden L.A., Roos D., and Kuijpers T.W. Mannan-binding lectin (MBL)-mediated opsonization is enhanced by the alternative pathway amplification loop. Mol. Immunol. 43 (2006) 2051
7. Burton D.R., and Dwek R.A. Immunology. Sugar determines antibody activity. Science 313 (2006) 627
8. Calvo-Alen J., Alarcon G.S., Tew M.B., Tan F.K., McGwin Jr. G., Fessler B.J., Vila L.M., and Reveille J.D. Systemic lupus erythematosus in a multiethnic US cohort: XXXIV. Deficient mannose-binding lectin exon 1 polymorphisms are associated with cerebrovascular but not with other arterial thrombotic events. Arthritis Rheum. 54 (2006) 1940
9. Cedzynski M., Szemraj J., Swierzko A.S., Bak-Romaniszyn L., Banasik M., Zeman K., and Kilpatrick D.C. Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system. Clin. Exp. Immunol. 136 (2004) 304
10. Collard C.D., Vakeva A., Morrissey M.A., Agah A., Rollins S.A., Reenstra W.R., Buras J.A., Meri S., and Stahl G.L. Complement activation after oxidative stress: role of the lectin complement pathway. Am. J. Pathol. 156 (2000) 1549
11. Dean M.M., Heatley S., and Minchinton R.M. Heteroligomeric forms of codon 54 mannose binding lectin (MBL) in circulation demonstrate reduced in vitro function. Mol. Immunol. 43 (2006) 950
12. Endo M., Ohi H., Ohsawa I., Fujita T., Matsushita M., and Fujita T. Glomerular deposition of mannose-binding lectin (MBL) indicates a novel mechanism of complement activation in IgA nephropathy. Nephrol. Dial. Transplant. 13 (1998) 1984
13. Fiane A.E., Videm V., Lingaas P.S., Heggelund L., Nielsen E.W., Geiran O.R., Fung M., and Mollnes T.E. Mechanism of complement activation and its role in the inflammatory response after thoracoabdominal aortic aneurysm repair. Circulation 108 (2003) 849
14. Font J., Ramos-Casals M., Brito-Zeron P., Nardi N., Ibanez A., Suarez B., Jimenez S., Tassies D., Garcia-Criado A., Ros E., Sentis J., Reverter J.C., and Lozano F. Association of mannose-binding lectin gene polymorphisms with antiphospholipid syndrome, cardiovascular disease and chronic damage in patients with systemic lupus erythematosus. Rheumatology (Oxford) 46 (2007) 76
15. Garred P., Madsen H.O., Marquart H., Hansen T.M., Sorensen S.F., Petersen J., Volck B., Svejgaard A., Graudal N.A., Rudd P.M., Dwek R.A., Sim R.B., and Andersen V. Two edged role of mannose binding lectin in rheumatoid arthritis: a cross sectional study. J. Rheumatol. 27 (2000) 26
16. Gomi K., Tokue Y., Kobayashi T., Takahashi H., Watanabe A., Fujita T., and Nukiwa T. Mannose-binding lectin gene polymorphism is a modulating factor in repeated respiratory infections. Chest 126 (2004) 95
17. Gupta B., Agrawal C., Raghav S.K., Das S.K., Das R.H., Chaturvedi V.P., and Das H.R. Association of mannose-binding lectin gene (MBL2) polymorphisms with rheumatoid arthritis in an Indian cohort of case-control samples. J. Hum. Genet. 50 (2005) 583
18. Hansen T.K., Thiel S., Knudsen S.T., Gravholt C.H., Christiansen J.S., Mogensen C.E., and Poulsen P.L. Elevated levels of mannan-binding lectin in patients with type 1 diabetes. J. Clin. Endocrinol. Metab. 88 (2003) 4857
19. Hansen T.K., Tarnow L., Thiel S., Steffensen R., Stehouwer C.D., Schalkwijk C.G., Parving H.H., and Flyvbjerg A. Association between mannose-binding lectin and vascular complications in type 1 diabetes. Diabetes 53 (2004) 1570
20. Hegele R.A., Ban M.R., Anderson C.M., and Spence J.D. Infection-susceptibility alleles of mannose-binding lectin are associated with increased carotid plaque area. J. Investig. Med. 48 (2000) 198
21. Hisano S., Matsushita M., Fujita T., Endo Y., and Takebayashi S. Mesangial IgA2 deposits and lectin pathway-mediated complement activation in IgA glomerulonephritis. Am. J. Kidney Dis. 38 (2001) 1082
22. Hovind P., Hansen T.K., Tarnow L., Thiel S., Steffensen R., Flyvbjerg A., and Parving H.H. Mannose-binding lectin as a predictor of microalbuminuria in type 1 diabetes: an inception cohort study. Diabetes 54 (2005) 1523
23. Kaur S., Gupta V.K., Shah A., Thiel S., Sarma P.U., and Madan T. Elevated levels of mannan-binding leptin (MBL) and eosinophilia in patients of bronchial asthma with allergic rhinitis and allergic bronchopulmonary aspergillosis associate with a novel intronic polymorphism in MBL. Clin. Exp. Immunol. 143 (2006) 414
24. Kuipers S., Aerts P.C., Cluysenaer O.J., Bartelink A.K., Ezekowitz R.A., Bax W.A., Salimans M., and Vandyk H. A case of familial meningococcal disease due to deficiency in mannose-binding lectin (MBL). Adv. Exp. Med. Biol. 531 (2003) 351
25. Madsen H.O., Garred P., Thiel S., Kurtzhals J.A., Lamm L.U., Ryder L.P., and Svejgaard A. Interplay between promoter and structural gene variants control basal serum level of mannan-binding protein. J. Immunol. 155 (1995) 3013
26. Madsen H.O., Videm V., Svejgaard A., Svennevig J.L., and Garred P. Association of mannose-binding lectin deficiency with severe atherosclerosis. Lancet 352 (1998) 959
27. Moller-Kristensen M., Jensenius J.C., Jensen L., Thielens N., Rossi V., Arlaud G., and Thiel S. Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals. J. Immunol. Methods 282 (2003) 159
28. Moller-Kristensen M., Ip W.K., Shi L., Gowda L.D., Hamblin M.R., Thiel S., Jensenius J.C., Ezekowitz R.A., and Takahashi K. Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa. J. Immunol. 176 (2006) 1769
29. Ohlenschlaeger T., Garred P., Madsen H.O., and Jacobsen S. Mannose-binding lectin variant alleles and the risk of arterial thrombosis in systemic lupus erythematosus. N. Engl. J. Med. 351 (2004) 260
30. Petersen S.V., Thiel S., Jensen L., Vorup-Jensen T., Koch C., and Jensenius J.C. Control of the classical and the MBL pathway of complement activation. Mol. Immunol. 37 (2000) 803
31. Petersen S.V., Thiel S., Jensen L., Steffensen R., and Jensenius J.C. An assay for the mannan-binding lectin pathway of complement activation. J. Immunol. Methods 257 (2001) 107
32. Poller L., Keown M., Chauhan N., van den Besselaar A.M., Meeuwisse-Braun J., Tripodi A., Clerici M., and Jespersen J. European concerted action on anticoagulation. Use of plasma samples to derive international sensitivity index for whole-blood prothrombin time monitors. Clin. Chem. 48 (2002) 255
33. Roos A., Bouwman L.H., Gijlswijk-Janssen D.J., Faber-Krol M.C., Stahl G.L., and Daha M.R. Human IgA activates the complement system via the mannan-binding lectin pathway. J. Immunol. 167 (2001) 2861
34. Roos A., Bouwman L.H., Munoz J., Zuiverloon T., Faber-Krol M.C., Fallaux-van den Houten F.C., Klar-Mohamad N., Hack C.E., Tilanus M.G., and Daha M.R. Functional characterization of the lectin pathway of complement in human serum. Mol. Immunol. 39 (2003) 655
35. Roos A., Rastaldi M.P., Calvaresi N., Oortwijn B.D., Schlagwein N., Van Gijlswijk-Janssen D.J., Stahl G.L., Matsushita M., Fujita T., van K.C., and Daha M.R. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J. Am. Soc. Nephrol. 17 (2006) 1724
36. Saevarsdottir S., Vikingsdottir T., Vikingsson A., Manfredsdottir V., Geirsson A.J., and Valdimarsson H. Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis, a prospective study. J. Rheumatol. 28 (2001) 728
37. Saevarsdottir S., Oskarsson O.O., Aspelund T., Eiriksdottir G., Vikingsdottir T., Gudnason V., and Valdimarsson H. Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk. J. Exp. Med. 201 (2005) 117
38. Scudiero O., Nardone G., Omodei D., Tatangelo F., Vitale D.F., Salvatore F., and Castaldo G. A mannose-binding lectin-defective haplotype is a risk factor for gastric cancer. Clin. Chem. 52 (2006) 1625
39. Seelen M.A., Roos A., Wieslander J., Mollnes T.E., Sjöholm A.G., Wurzner R., Loos M., Tedesco F., Sim R.B., Garred P., Alexopoulos E., Turner M.W., and Daha M.R. Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA. J. Immunol. Methods 296 (2005) 187
40. Seelen M.A., van der Bijl E.A., Trouw L.A., Zuiverloon T.C., Munoz J.R., Fallaux-van den Houten F.C., Schlagwein N., Daha M.R., Huizinga T.W., and Roos A. A role for mannose-binding lectin dysfunction in generation of autoantibodies in systemic lupus erythematosus. Rheumatology (Oxford) 44 (2005) 111
41. Selander B., Martensson U., Weintraub A., Holmstrom E., Matsushita M., Thiel S., Jensenius J.C., Truedsson L., and Sjoholm A.G. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J. Clin. Invest. 116 (2006) 1425
42. Sjoholm A.G., Jonsson G., Braconier J.H., Sturfelt G., and Truedsson L. Complement deficiency and disease: an update. Mol. Immunol. 43 (2006) 78
43. Sorensen G.L., Petersen I., Thiel S., Fenger M., Christensen K., Kyvik K.O., Sorensen T.I., Holmskov U., and Jensenius J.C. Genetic influences on mannan-binding lectin (MBL) and mannan-binding lectin associated serine protease-2 (MASP-2) activity. Genet. Epidemiol. 31 (2007) 31
44. Spence J.D., and Norris J. Infection, inflammation, and atherosclerosis. Stroke 34 (2003) 333
45. Stahl G.L., Xu Y., Hao L., Miller M., Buras J.A., Fung M., and Zhao H. Role for the alternative complement pathway in ischemia/reperfusion injury. Am. J. Pathol. 162 (2003) 455
46. Steffensen R., Thiel S., Varming K., Jersild C., and Jensenius J.C. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J. Immunol. Methods 241 (2000) 33
47. Super M., Levinsky R.J., and Turner M.W. The level of mannan-binding protein regulates the binding of complement-derived opsonins to mannan and zymosan at low serum concentrations. Clin. Exp. Immunol. 79 (1990) 144
48. Takahashi R., Tsutsumi A., Ohtani K., Muraki Y., Goto D., Matsumoto I., Wakamiya N., and Sumida T. Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus. Ann. Rheum. Dis. 64 (2005) 311
49. Terai I., Kobayashi K., Matsushita M., Miyakawa H., Mafune N., and Kikuta H. Relationship between gene polymorphisms of mannose-binding lectin (MBL) and two molecular forms of MBL. Eur. J. Immunol. 33 (2003) 2755
50. Thiel S., Moller-Kristensen M., Jensen L., and Jensenius J.C. Assays for the functional activity of the mannan-binding lectin pathway of complement activation. Immunobiology 205 (2002) 446
51. Tosic L., Sutherland W.M., Kurek J., Edberg J.C., and Taylor R.P. Preparation of monoclonal antibodies to C3b by immunization with C3b(i)-sepharose. J. Immunol. Methods 120 (1989) 241
52. van Emmerik L.C., Kuijper E.J., Fijen C.A., Dankert J., and Thiel S. Binding of mannan-binding protein to various bacterial pathogens of meningitis. Clin. Exp. Immunol. 97 (1994) 411
53. Zhang H., Zhou G., Zhi L., Yang H., Zhai Y., Dong X., Zhang X., Gao X., Zhu Y., and He F. Association between mannose-binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection. J. Infect. Dis. 192 (2005) 1355