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1
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13444270334
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Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden
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Nilsson B, Bumming P, Meis-Kindblom JM, et al. Gastrointestinal stromal tumors: The incidence, prevalence, clinical course, and prognostication in the preimatinib mesylate era-a population-based study in western Sweden. Cancer 2005; 103:821-829.
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(2005)
Cancer
, vol.103
, pp. 821-829
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Nilsson, B.1
Bumming, P.2
Meis-Kindblom, J.M.3
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2
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33845940073
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Agaimy A, Wunsch PH, Hostaedter F, et al. Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations. Am J Surg Pathol 2007; 31:113-120. This highly interesting study reported the presence of many microscopic GISTs in the stomachs of adults representing the general population. Many microscopic GISTs contained KITmutation. Similar findings have been reported by Kawanowa et al. (Hum Pathol 2006; 37:1527-1535).
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Agaimy A, Wunsch PH, Hostaedter F, et al. Minute gastric sclerosing stromal tumors (GIST tumorlets) are common in adults and frequently show c-KIT mutations. Am J Surg Pathol 2007; 31:113-120. This highly interesting study reported the presence of many microscopic GISTs in the stomachs of adults representing the general population. Many microscopic GISTs contained KITmutation. Similar findings have been reported by Kawanowa et al. (Hum Pathol 2006; 37:1527-1535).
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3
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33750595859
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Heinrich MC, Corless CL, Blanke CD, et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006; 24:4764-4774. This report contains a summary of secondary mutations found in GISTs treated with imatinib.
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Heinrich MC, Corless CL, Blanke CD, et al. Molecular correlates of imatinib resistance in gastrointestinal stromal tumors. J Clin Oncol 2006; 24:4764-4774. This report contains a summary of secondary mutations found in GISTs treated with imatinib.
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4
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33746401591
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Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006; 42:1093-1103. A large series addressing the predictive value of KIT and PDGFRA mutations on response to imatinib administered at either 400 mg or 800mg per day.
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Debiec-Rychter M, Sciot R, Le Cesne A, et al. KIT mutations and dose selection for imatinib in patients with advanced gastrointestinal stromal tumours. Eur J Cancer 2006; 42:1093-1103. A large series addressing the predictive value of KIT and PDGFRA mutations on response to imatinib administered at either 400 mg or 800mg per day.
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5
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33747592782
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Response evaluation in gastrointestinal stromal tumors treated with imatinib:misdiagnosis of liver progression onCT due to cystic change in liver metastases
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Linton KM, Taylor MB, Radford JA. Response evaluation in gastrointestinal stromal tumors treated with imatinib:misdiagnosis of liver progression onCT due to cystic change in liver metastases. Br J Radiol 2006; 79:e40-e44.
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(2006)
Br J Radiol
, vol.79
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Linton, K.M.1
Taylor, M.B.2
Radford, J.A.3
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6
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33750631550
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Occurrence of other malignancies in patients with gastrointestinal stromal tumors
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Agaimy A, Wunsch PH, Sobin LH, et al. Occurrence of other malignancies in patients with gastrointestinal stromal tumors. Semin Diagn Pathol 2006; 23:120-129.
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(2006)
Semin Diagn Pathol
, vol.23
, pp. 120-129
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Agaimy, A.1
Wunsch, P.H.2
Sobin, L.H.3
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7
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18844457915
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Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate
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Shankar S, vanSonnenberg E, Deasi J, et al. Gastrointestinal stromal tumor: New nodule-within-a-mass pattern of recurrence after partial response to imatinib mesylate. Radiology 2005; 235:892-898.
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(2005)
Radiology
, vol.235
, pp. 892-898
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Shankar, S.1
vanSonnenberg, E.2
Deasi, J.3
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8
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23644452642
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Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800mg after progression on 400 mg
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Zalcberg JR, Verweij J, Casali PG, et al. Outcome of patients with advanced gastro-intestinal stromal tumours crossing over to a daily imatinib dose of 800mg after progression on 400 mg. Eur J Cancer 2005; 41: 1751-1757.
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(2005)
Eur J Cancer
, vol.41
, pp. 1751-1757
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Zalcberg, J.R.1
Verweij, J.2
Casali, P.G.3
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9
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33748376520
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Phase I/II study of imatinib mesylate for recurrent malignant liomas: North American Brain Tumor Consortium Study 99-08
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Wen PY, Young WK, Lamborn KR, et al. Phase I/II study of imatinib mesylate for recurrent malignant liomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 2006; 12:4899-4907.
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(2006)
Clin Cancer Res
, vol.12
, pp. 4899-4907
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Wen, P.Y.1
Young, W.K.2
Lamborn, K.R.3
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10
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33744795769
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Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors
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Raut CP, Posner M, Desai J, et al. Surgical management of advanced gastrointestinal stromal tumors after treatment with targeted systemic therapy using kinase inhibitors. J Clin Oncol 2006; 24:2325-2331.
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(2006)
J Clin Oncol
, vol.24
, pp. 2325-2331
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Raut, C.P.1
Posner, M.2
Desai, J.3
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11
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34249980075
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Pattern of progression and its impact on outcome in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: A retrospective multicenter long-term follow-up study [abstract]
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530s
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Hartmann JT, Heidel F, Stoehlmacher J, et al. Pattern of progression and its impact on outcome in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: A retrospective multicenter long-term follow-up study [abstract]. J Clin Oncol 2006; 24:530s.
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(2006)
J Clin Oncol
, vol.24
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Hartmann, J.T.1
Heidel, F.2
Stoehlmacher, J.3
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12
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34250002246
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Surgical interventions for focal progression of gastrointestinal stromal tumors under imatinib therapy [abstract]
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531s
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Nishida T, Hasegawa J, Nishitani A, et al. Surgical interventions for focal progression of gastrointestinal stromal tumors under imatinib therapy [abstract]. J Clin Oncol 2006; 24:531s.
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(2006)
J Clin Oncol
, vol.24
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Nishida, T.1
Hasegawa, J.2
Nishitani, A.3
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13
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33746625622
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Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: Enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling
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Ikezoe T, Yang Y, Nishioka C, et al. Effect of SU11248 on gastrointestinal stromal tumor-T1 cells: Enhancement of growth inhibition via inhibition of 3-kinase/Akt/mammalian target of rapamycin signaling. Cancer Sci 2006; 97: 945-951.
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(2006)
Cancer Sci
, vol.97
, pp. 945-951
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Ikezoe, T.1
Yang, Y.2
Nishioka, C.3
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14
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33646432734
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Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate
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Prenen H, Cools J, Mentens N, et al. Efficacy of the kinase inhibitor SU11248 against gastrointestinal stromal tumor mutants refractory to imatinib mesylate. Clin Cancer Res 2006; 12:2622-2627.
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(2006)
Clin Cancer Res
, vol.12
, pp. 2622-2627
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Prenen, H.1
Cools, J.2
Mentens, N.3
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15
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33749505836
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Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006; 368:1329-1338. This pivotal trial compared sumitinib malate with placebo in GIST patients who were either intolerant to imatinib or whose disease progressed while on imatinib therapy. The largest ever conducted study to evaluate systemic second-line therapies in GIST. Median time to tumor progression was 27.3 weeks in patients receiving sunitinib and 6.4 weeks in those on placebo.
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Demetri GD, van Oosterom AT, Garrett CR, et al. Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 2006; 368:1329-1338. This pivotal trial compared sumitinib malate with placebo in GIST patients who were either intolerant to imatinib or whose disease progressed while on imatinib therapy. The largest ever conducted study to evaluate systemic second-line therapies in GIST. Median time to tumor progression was 27.3 weeks in patients receiving sunitinib and 6.4 weeks in those on placebo.
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16
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1842579584
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Serum KIT, SCF and VEGF levels in gastrointestinal tumor patients treated with imatinib
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Bono P, Krause A, Blanke CD, et al. Serum KIT, SCF and VEGF levels in gastrointestinal tumor patients treated with imatinib. Blood 2004; 103:2929-2935.
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(2004)
Blood
, vol.103
, pp. 2929-2935
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Bono, P.1
Krause, A.2
Blanke, C.D.3
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17
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33748948155
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Sunitinib response in imatinibresistant GIST correlates with KIT and PDGFRA mutation status [abstract]
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520s
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Heinrich MC, Maki RG, Corless CL, et al. Sunitinib response in imatinibresistant GIST correlates with KIT and PDGFRA mutation status [abstract]. J Clin Oncol 2006; 24:520s.
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(2006)
J Clin Oncol
, vol.24
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Heinrich, M.C.1
Maki, R.G.2
Corless, C.L.3
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18
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33750961647
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Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors
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This important study demonstrated frequent abnormalities in the thyroid function and clinical hypothyroidism in GIST patients treated with sunitinib. Some patients developed destructive thyroiditis through follicular cell apoptosis
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Desai J, Yassa L, Marqusee S, et al. Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 2006; 145:660-664. This important study demonstrated frequent abnormalities in the thyroid function and clinical hypothyroidism in GIST patients treated with sunitinib. Some patients developed destructive thyroiditis through follicular cell apoptosis.
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(2006)
Ann Intern Med
, vol.145
, pp. 660-664
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Desai, J.1
Yassa, L.2
Marqusee, S.3
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19
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33846978108
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Rini BI, Tamaskar I, Shaheen P, et al. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2007; 99:81-83. This study found a high frequency of thyroid function abnormalities in patients treated with sunitinib for renal cell cancer.
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Rini BI, Tamaskar I, Shaheen P, et al. Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 2007; 99:81-83. This study found a high frequency of thyroid function abnormalities in patients treated with sunitinib for renal cell cancer.
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20
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33845586403
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Kobayashi K, Gupta S, Trent JC, et al. Hepatic artery chemoembolozation for 110 gastrointestinal stromal tumors. Cancer 2006; 107:2833-2841. This is probably the largest single-center series on hepatic artery chemoembolization in GIST published to date. The data suggest that many GIST patients with metastases in the liver may benefit from chemoembolization.
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Kobayashi K, Gupta S, Trent JC, et al. Hepatic artery chemoembolozation for 110 gastrointestinal stromal tumors. Cancer 2006; 107:2833-2841. This is probably the largest single-center series on hepatic artery chemoembolization in GIST published to date. The data suggest that many GIST patients with metastases in the liver may benefit from chemoembolization.
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21
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33749588511
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Treatment of metastatic sarcoma to the liver with bland embolization
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Maluccio MA, Covey AM, Schubert J, et al. Treatment of metastatic sarcoma to the liver with bland embolization. Cancer 2006; 107:1617-1623.
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(2006)
Cancer
, vol.107
, pp. 1617-1623
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Maluccio, M.A.1
Covey, A.M.2
Schubert, J.3
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22
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26044479980
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A phase I/II trial of the oral mTOR inhibitor everolimus and imatinib in patients with gastrointestinal stromal tumor refractory to imatinib:study uptate [abstract]
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824s
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van Oosterom A, Reichardt P, Blay J-Y, et al. A phase I/II trial of the oral mTOR inhibitor everolimus and imatinib in patients with gastrointestinal stromal tumor refractory to imatinib:study uptate [abstract]. J Clin Oncol 2005; 23:824s.
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(2005)
J Clin Oncol
, vol.23
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van Oosterom, A.1
Reichardt, P.2
Blay, J.-Y.3
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23
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33750944505
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A phase II, open-label study of PTK787/ ZK222584 in the treatment of metastatic gastrointestinal stromal tumors (GISTs) resistant to imatinib mesylate [abstract]
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527s
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Joensuu H, De Braud F, Coco P, et al. A phase II, open-label study of PTK787/ ZK222584 in the treatment of metastatic gastrointestinal stromal tumors (GISTs) resistant to imatinib mesylate [abstract]. Proc Am Soc Clin Oncol 2006; 24:527s.
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(2006)
Proc Am Soc Clin Oncol
, vol.24
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Joensuu, H.1
De Braud, F.2
Coco, P.3
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24
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14944352767
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Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants
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Debiec-Rychter M, Cools J, Dumez H, et al. Mechanisms of resistance to imatinib mesylate in gastrointestinal stromal tumors and activity of the PKC412 inhibitor against imatinib-resistant mutants. Gastroenterology 2005; 128:270-279.
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(2005)
Gastroenterology
, vol.128
, pp. 270-279
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Debiec-Rychter, M.1
Cools, J.2
Dumez, H.3
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25
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34250013361
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A phase I/II trial of the oral PKC-inhibitor PKC416 in combination with imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to imatinib [abstract]
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196s
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Reichardt P, Pink D, Linder T, et al. A phase I/II trial of the oral PKC-inhibitor PKC416 in combination with imatinib mesylate in patients with gastrointestinal stromal tumor (GIST) refractory to imatinib [abstract]. J Clin Oncol 2005; 23:196s.
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(2005)
J Clin Oncol
, vol.23
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Reichardt, P.1
Pink, D.2
Linder, T.3
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26
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34250005153
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Assessment of response using FGD-PET and CT in a phase I study of AMN107 alone or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors (GIST) [abstract]
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142s
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Van Den Abbeele AD, Barnes AS, De Vries JD, et al. Assessment of response using FGD-PET and CT in a phase I study of AMN107 alone or in combination with imatinib in patients with imatinib-resistant gastrointestinal stromal tumors (GIST) [abstract]. J Clin Oncol 2006; 24:142s.
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(2006)
J Clin Oncol
, vol.24
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Van Den Abbeele, A.D.1
Barnes, A.S.2
De Vries, J.D.3
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27
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31544459272
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Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
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Schittenhelm MM, Shiraga S, Schroeder A, et al. Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res 2006; 66:473-481.
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(2006)
Cancer Res
, vol.66
, pp. 473-481
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Schittenhelm, M.M.1
Shiraga, S.2
Schroeder, A.3
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28
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33745914717
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Phase I dose-escalation study of the SRC and multikinase inhibitor BMS-354825 in patients with GIST and other solid tumors [abstract]
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200s
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Evans TRJ, Morgan JA, van den Abbeele AD, et al. Phase I dose-escalation study of the SRC and multikinase inhibitor BMS-354825 in patients with GIST and other solid tumors [abstract]. J Clin Oncol 2005; 23:200s.
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(2005)
J Clin Oncol
, vol.23
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Evans, T.R.J.1
Morgan, J.A.2
van den Abbeele, A.D.3
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29
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33749461709
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Heat shock mprotein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor
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Bauer S, Yu LK, Demetri GD, Fletcher JA. Heat shock mprotein 90 inhibition in imatinib-resistant gastrointestinal stromal tumor. Cancer Res 2006; 66:9153-9161.
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(2006)
Cancer Res
, vol.66
, pp. 9153-9161
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Bauer, S.1
Yu, L.K.2
Demetri, G.D.3
Fletcher, J.A.4
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30
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33745259006
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Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells
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Sambol EB, Ambrosini G, Geha RC, et al. Flavopiridol targets c-KIT transcription and induces apoptosis in gastrointestinal stromal tumor cells. Cancer Res 2006; 66:5858-5866.
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(2006)
Cancer Res
, vol.66
, pp. 5858-5866
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Sambol, E.B.1
Ambrosini, G.2
Geha, R.C.3
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