Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition

Journal of Antimicrobial Chemotherapy

Volumn 59, Issue 4, 2007, Pages 681-689

  Seaton, Claire ^a   Ignas, James ^a   Muchohi, Simon ^a,b   Kokwaro, Gilbert ^a,b   Maitland, Kathryn ^a,c   Thomson, Alison H ^d,e  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF NAIROBI   (Kenya)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^e WESTERN INFIRMARY   (United Kingdom)

Author keywords

Africa; Antimicrobial therapy; Kwashiorkor; Marasmus; Parenteral; Population pharmacokinetics

Indexed keywords

AMOXICILLIN; AMPICILLIN; CHLORAMPHENICOL; CREATININE; GENTAMICIN; MEBENDAZOLE; ANTIINFECTIVE AGENT;

ANTIBIOTIC THERAPY; ARTICLE; BODY WEIGHT; CHILD; CLINICAL ARTICLE; COMPARTMENT MODEL; COMPUTER PROGRAM; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE SEVERITY; DRUG ABSORPTION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; HUMAN; HYPOVOLEMIC SHOCK; INDIVIDUALIZATION; INFANT; KIDNEY DYSFUNCTION; LOW TEMPERATURE; MALE; MALNUTRITION; PRACTICE GUIDELINE; SINGLE DRUG DOSE; BLOOD; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; FLUORESCENCE POLARIZATION IMMUNOASSAY; INTRAMUSCULAR DRUG ADMINISTRATION; KIDNEY FUNCTION TEST; METABOLISM; POPULATION; PRESCHOOL CHILD; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL;

ANTI-BACTERIAL AGENTS; CHILD; CHILD, PRESCHOOL; CREATININE; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; GENTAMICINS; HUMANS; INFANT; INJECTIONS, INTRAMUSCULAR; KIDNEY FUNCTION TESTS; MALE; MALNUTRITION; MODELS, STATISTICAL; POPULATION;

EID: 34249988312     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dkl561     Document Type: Article

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