From the one-bead-one-compound concept to one-bead-one-reactor

Journal of Combinatorial Chemistry

Volumn 9, Issue 3, 2007, Pages 395-398

  Marani, Mariela M ^b,c   Paradís Bas, Marta ^b   Tulla Puche, Judit ^b   Côté, Simón ^d   Camperi, Silvia A ^c   Cascone, Osvaldo ^a,c   Albericio, Fernando ^b,e  

^a Barcelona Science Park ^*

^b UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^c Matrix Innovation Inc   (Canada)

^d UNIVERSITY OF BARCELONA   (Spain)

^e INSTITUTE FOR RESEARCH IN BIOMEDICINE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

MACROGOL DERIVATIVE; PEPTIDE; RESIN; WATER;

ARTICLE; CHEMISTRY; COMBINATORIAL CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; SENSITIVITY AND SPECIFICITY; SYNTHESIS;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMBINATORIAL CHEMISTRY TECHNIQUES; PEPTIDES; POLYETHYLENE GLYCOLS; RESINS, SYNTHETIC; SENSITIVITY AND SPECIFICITY; WATER;

EID: 34249947920     PISSN: 15204766     EISSN: None     Source Type: Journal    
DOI: 10.1021/cc070012h     Document Type: Article

References (23)

1. The following abbreviations are used: ACN, acetonitrile; AcOH, acetic acid; CHCA, α-cyano-4-hydroxycinnamic acid; CM, ChemMatrix; DABS, dabsyl; DMF, N,N-dimethylformamide; DIPCDI, N,N′-diisopropylcarbodiimide; DMAP, N,N-dimethylaminopyridine; DIEA, N,N′ diisopropylethylamine; Fmoc, 9-fluorenylmethoxycarbonyl; HMBA, 4-hydroxymethylbenzoic acid; HPLC, high performance liquid chromatography; MALDI-TOF, matrix-assisted desorption ionization time of flight; MS, mass spectrometry; OBOC, one-bead-one-compound; OBOR, one-bead-one-reactor; PAL, peptide amide linker; PEG, polyethylene glycol; TBTU, 1-[bis(dimethylamino)methylene]-1H-benzotriazolium tetrafluoroborate 3-oxide; TFA, trifluoroacetic acid; THF, tetrahydrofuran.
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