P450 phenotyping of the metabolism of selegiline to desmethylselegiline and methamphetamine.

Drug metabolism and pharmacokinetics

Volumn 22, Issue 2, 2007, Pages 78-87

  Benetton, Salete A ^a   Fang, Che ^a   Yang, Yan ou ^a   Alok, Ramya ^a   Year, Mey ^a   Lin, Chin Chung ^a   Yeh, Li Tain ^a  

^a Valeant Research and Development   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHETAMINE DERIVATIVE; COUMARIN 7 HYDROXYLASE; COUMARIN 7-HYDROXYLASE; CYP3A4 PROTEIN, HUMAN; CYTOCHROME P450; DESMETHYLSELEGILINE; DOPAMINE UPTAKE INHIBITOR; ENZYME INHIBITOR; METHAMPHETAMINE; MIXED FUNCTION OXIDASE; MONOAMINE OXIDASE INHIBITOR; MONOCLONAL ANTIBODY; N DEMETHYLASE; RECOMBINANT PROTEIN; S MEPHENYTOIN N DEMETHYLASE; S-MEPHENYTOIN N-DEMETHYLASE; SELEGILINE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE;

ARTICLE; BIOTRANSFORMATION; CHEMICAL STRUCTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOLOGY; IN VITRO STUDY; LIVER; LIVER MICROSOME; METABOLISM; METHODOLOGY; PHENOTYPE; TANDEM MASS SPECTROMETRY;

AMPHETAMINES; ANTIBODIES, MONOCLONAL; ARYL HYDROCARBON HYDROXYLASES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; LIVER; METHAMPHETAMINE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MOLECULAR STRUCTURE; MONOAMINE OXIDASE INHIBITORS; OXIDOREDUCTASES, N-DEMETHYLATING; PHENOTYPE; RECOMBINANT PROTEINS; SELEGILINE; TANDEM MASS SPECTROMETRY;

EID: 34249941679     PISSN: 13474367     EISSN: None     Source Type: Journal    
DOI: 10.2133/dmpk.22.78     Document Type: Article

References (0)