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Volumn 22, Issue 2, 2007, Pages 113-118
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Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate.
a
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Author keywords
[No Author keywords available]
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Indexed keywords
CARBON;
CYP3A4 PROTEIN, HUMAN;
CYTOCHROME P450;
DEXTRORPHAN;
ENZYME INHIBITOR;
ERYTHROMYCIN;
KETOCONAZOLE;
MIDAZOLAM;
NITROGEN;
UNCLASSIFIED DRUG;
ARTICLE;
ARTIFACT;
DOSE RESPONSE;
DRUG ANTAGONISM;
DRUG EFFECT;
DRUG SCREENING;
ENZYMOLOGY;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HUMAN;
HYDROXYLATION;
IN VITRO STUDY;
LIVER;
LIVER MICROSOME;
METABOLISM;
METHODOLOGY;
MOLECULAR PROBE;
REPRODUCIBILITY;
TANDEM MASS SPECTROMETRY;
ARTIFACTS;
CARBON ISOTOPES;
CHROMATOGRAPHY, HIGH PRESSURE LIQUID;
CYTOCHROME P-450 ENZYME SYSTEM;
DEXTRORPHAN;
DOSE-RESPONSE RELATIONSHIP, DRUG;
DRUG EVALUATION, PRECLINICAL;
ENZYME INHIBITORS;
ERYTHROMYCIN;
HUMANS;
HYDROXYLATION;
KETOCONAZOLE;
LIVER;
MICROSOMES, LIVER;
MIDAZOLAM;
MOLECULAR PROBES;
NITROGEN ISOTOPES;
REPRODUCIBILITY OF RESULTS;
TANDEM MASS SPECTROMETRY;
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EID: 34249936412
PISSN: 13474367
EISSN: None
Source Type: Journal
DOI: 10.2133/dmpk.22.113 Document Type: Article |
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Times cited : (5)
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References (0)
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