Suppression of LTP-like plasticity in human motor cortex by the GABA B receptor agonist baclofen

Experimental Brain Research

Volumn 180, Issue 1, 2007, Pages 181-186

  McDonnell, Michelle N ^a   Orekhov, Yuri ^b,c   Ziemann, Ulf ^b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b GOETHE UNIVERSITY   (Germany)

^c INSTITUTE OF HIGHER NERVOUS ACTIVITY AND NEUROPHYSIOLOGY   (Russian Federation)

Author keywords

Baclofen; GABAB receptor; Human motor cortex; LTP like plasticity; Paired associative stimulation; Transcranial magnetic stimulation

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ASCORBIC ACID; BACLOFEN; PLACEBO;

ADULT; ARTICLE; ASSOCIATION; CONTROLLED STUDY; DATA ANALYSIS; DRUG EFFECT; ELECTROSTIMULATION; FEMALE; HUMAN; INHIBITORY POSTSYNAPTIC POTENTIAL; LONG TERM POTENTIATION; MALE; MOTOR CORTEX; NERVE CELL PLASTICITY; NORMAL HUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; TRANSCRANIAL MAGNETIC STIMULATION;

ADULT; ANALYSIS OF VARIANCE; BACLOFEN; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; EVOKED POTENTIALS, MOTOR; FEMALE; GABA AGONISTS; HUMANS; LINEAR MODELS; LONG-TERM POTENTIATION; MALE; MEDIAN NERVE; MOTOR CORTEX; PYRAMIDAL TRACTS; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 34249915497     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00221-006-0849-0     Document Type: Article

References (32)

1. Artola A, Bröcher S, Singer W (1990) Different voltage-dependent thresholds for inducing long-term depression and long-term potentiation in slices of rat visual cortex. Nature 347:69-72
2. Bütefisch CM, Davis BC, Wise SP, Sawaki L, Kopylev L, Classen J, Cohen LG (2000) Mechanisms of use-dependent plasticity in the human motor cortex. Proc Natl Acad Sci USA 97:3661-3665
3. Davies CH, Starkey SJ, Pozza MF, Collingridge GL (1991) GABA autoreceptors regulate the induction of LTP. Nature 349:609-611
4. Deisz RA (1999) The GABA(B) receptor antagonist CGP 55845A reduces presynaptic GABA(B) actions in neocortical neurons of the rat in vitro. Neuroscience 93:1241-1249
5. Di Lazzaro V, Restuccia D, Oliviero A, Profice P, Ferrara L, Insola A, Mazzone P, Tonali P, Rothwell JC (1998) Magnetic transcranial stimulation at intensities below active motor threshold activates intracortical inhibitory circuits. Exp Brain Res 119:265-268
6. Di Lazzaro V, Oliviero A, Meglio M, Cioni B, Tamburrini G, Tonali P, Rothwell JC (2000) Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex. Clin Neurophysiol 111:794-799
7. Di Lazzaro V, Pilato F, Dileone M, Ranieri F, Ricci V, Profice P, Bria P, Tonali PA, Ziemann U (2006) GABAA receptor subtype specific enhancement of inhibition in human motor cortex. J Physiol 575:721-726
8. Ilic TV, Meintzschel F, Cleff U, Ruge D, Kessler KR, Ziemann U (2002) Short-interval paired-pulse inhibition and facilitation of human motor cortex: the dimension of stimulus intensity. J Physiol 545.1:153-167
9. Kofler M, Donovan WH, Loubser PG, Beric A (1992) Effects of intrathecal baclofen on lumbosacral and cortical somatosensory evoked potentials. Neurology 42:864-868
10. Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD (1993) Corticocortical inhibition in human motor cortex. J Physiol (Lond) 471:501-519
11. McDonnell MN, Orekhov Y, Ziemann U (2006) The role of GABA(B) receptors in intracortical inhibition in the human motor cortex. Exp Brain Res 173:86-93
12. McNamara RK, Skelton RW (1996) Baclofen, a selective GABAB receptor agonist, dose-dependently impairs spatial learning in rats. Pharmacol Biochem Behav 53:303-308
13. Mott DD, Lewis DV (1991) Facilitation of the induction of long-term potentiation by GABAB receptors. Science 252:1718-1720
14. Mott DD, Lewis DV, Ferrari CM, Wilson WA, Swartzwelder HS (1990) Baclofen facilitates the development of long-term potentiation in the rat dentate gyrus. Neurosci Lett 113:222-226
15. Nakamura H, Kitagawa H, Kawaguchi Y, Tsuji H (1997) Intracortical facilitation and inhibition after transcranial magnetic stimulation in conscious humans. J Physiol (Lond) 498:817-823
16. Olpe HR, Karlsson G (1990) The effects of baclofen and two GABAB-receptor antagonists on long-term potentiation. Naunyn Schmiedebergs Arch Pharmacol 342:194-197
17. Olpe HR, Worner W, Ferrat T (1993) Stimulation parameters determine role of GABAB receptors in long-term potentiation. Experientia 49:542-546
18. Rioult-Pedotti MS, Friedman D, Donoghue JP (2000) Learning-induced LTP in neocortex. Science 290:533-536
19. Soto C, Martin-Cora F, Leiras R, Velo P, Canedo A (2006) GABA(B) receptor-mediated modulation of cutaneous input at the cuneate nucleus in anesthetized cats. Neuroscience 137:1015-1030
20. Stäubli U, Scafidi J, Chun D (1999) GABAB receptor antagonism: facilitatory effects on memory parallel those on LTP induced by TBS but not HFS. J Neurosci 19:4609-4615
21. Stefan K, Kunesch E, Cohen LG, Benecke R, Classen J (2000) Induction of plasticity in the human motor cortex by paired associative stimulation. Brain 123:572-584
22. Stefan K, Kunesch E, Benecke R, Cohen LG, Classen J (2002) Mechanisms of enhancement of human motor cortex excitability induced by interventional paired associative stimulation. J Physiol 543:699-708
23. Stefan K, Wycislo M, Gentner R, Schramm A, Naumann M, Reiners K, Classen J (2006) Temporary occlusion of associative motor cortical plasticity by prior dynamic motor training. Cereb Cortex 16:376-385
24. Valls-Sole J, Pascual-Leone A, Wassermann EM, Hallett M (1992) Human motor evoked responses to paired transcranial magnetic stimuli. Electroencephalogr Clin Neurophysiol 85:355-364
25. Ziemann U, Lönnecker S, Steinhoff BJ, Paulus W (1996a) The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res 109:127-135
26. Ziemann U, Rothwell JC, Ridding MC (1996b) Interaction between intracortical inhibition and facilitation in human motor cortex. J Physiol (Lond) 496:873-881
27. Ziemann U, Corwell B, Cohen LG (1998a) Modulation of plasticity in human motor cortex after forearm ischemic nerve block. J Neurosci 18:1115-1123
28. Ziemann U, Hallett M, Cohen LG (1998b) Mechanisms of deafferentation- induced plasticity in human motor cortex. J Neurosci 18:7000-7007
29. Ziemann U, Muellbacher W, Hallett M, Cohen LG (2001) Modulation of practice-dependent plasticity in human motor cortex. Brain 124:1171-1181
30. Ziemann U, Ilic TV, Pauli C, Meintzschel F, Ruge D (2004) Learning modifies subsequent induction of LTP-like and LTD-like plasticity in human motor cortex. J Neurosci 24:1666-1672
31. Ziemann U, Ilic TV, Jung P (2006a) Long-term potentiation (LTP)-like plasticity and learning in human motor cortex-investigations with transcranial magnetic stimulation (TMS). Suppl Clin Neurophysiol 59:19-25
32. Ziemann U, Meintzschel F, Korchounov A, Ilic TV (2006b) Pharmacological modulation of plasticity in the human motor cortex. Neurorehabil Neural Repair 20:243-251