Insonation of the eye in the presence of microbubbles: Preliminary study of the duration and degree of vascular bioeffects - Work in progress

Journal of Ultrasound in Medicine

Volumn 26, Issue 6, 2007, Pages 731-738

  Hirokawa, Tomihiko ^a,b   Karshafian, Raffi ^a,b   Pavlin, Charles J ^c   Burns, Peter N ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Bioeffects; Rabbit eye vasoconstriction; Therapeutic ultrasound; Ultrasound contrast agents

Indexed keywords

ANGIOGRAPHY; ANIMALS; CONTRAST MEDIA; TIME DELAY; VISION;

BIOEFFECTS; RABBIT EYE VASOCONSTRICTION; THERAPEUTIC ULTRASOUNDS; ULTRASOUND CONTRAST AGENTS;

ULTRASONIC IMAGING;

FLUORESCEIN; FLUORESCEIN SODIUM; PERFLUTREN;

ABSENCE OF SIDE EFFECTS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; B SCAN; BLOOD VESSEL PERMEABILITY; CONTRAST MEDIUM EXTRAVASATION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG DELIVERY SYSTEM; ECHOOCULOGRAPHY; EYE PHOTOGRAPHY; FLUORESCENCE ANGIOGRAPHY; HUMAN; INTRAOCULAR HEMORRHAGE; MICROBUBBLE; NONHUMAN; OPHTHALMOSCOPY; OPTICS; RABBIT; VASOCONSTRICTION;

EID: 34249904898     PISSN: 02784297     EISSN: None     Source Type: Journal    
DOI: 10.7863/jum.2007.26.6.731     Document Type: Article

References (13)

1. Dijkmans PA, Juffermans LJ, Musters RJ, et al. Microbubbles and ultrasound: from diagnosis to therapy. Eur J Echocardiogr 2004; 5:245-256.
2. Unger EC, Matsunaga TO, McCreery T, Schumann P, Sweitzer R, Quigley R. Therapeutic applications of microbubbles. Eur J Radiol 2002; 42:160-168.
3. Miller DL, Dou C. Membrane damage thresholds for pulsed or continuous ultrasound in phagocytic cells loaded with contrast agent gas bodies. Ultrasound Med Biol 2004; 30:405-411.
4. Skyba DM, Price RJ, Linka AZ, Skalak TC, Kaul S. Direct in vivo visualization of intravascular destruction of microbubbles by ultrasound and its local effects on tissue. Circulation 1998; 98:290-293.
5. Miller DL, Quddus J. Diagnostic ultrasound activation of contrast agent gas bodies induces capillary rupture in mice. Proc Natl Acad Sci USA 2000; 97:10181-10184.
6. Philips Medical Systems. Table 10, revision D1. In: Sonos 7500 Output Display Standard and Acoustic ODS Tables. Bothell, WA: Philips Medical Systems; 2003:2-13.
7. Kobayashi N, Yasu T, Yamada S, et al. Endothelial cell injury in venule and capillary induced by contrast ultrasonography. Ultrasound Med Biol 2002; 28:949-956.
8. Mehier-Humbert S, Bettinger T, Yan F, Guy RH. Plasma membrane poration induced by ultrasound exposure: implication for drug delivery. J Control Release 2005; 104: 213-222.
9. Kobayashi N, Yasu T, Yamada S, et al. Influence of contrast ultrasonography with perflutren lipid microspheres on microvessel injury. Circ J 2003; 67:630-636.
10. Hwang JH, Brayman AA, Reidy MA, Matula TJ, Kimmey MB, Crum LA. Vascular effects induced by combined 1-MHz ultrasound and microbubble contrast agent treatments in vivo. Ultrasound Med Biol 2005; 31:553-564.
11. Lewis T. The Blood Vessels of the Human Skin and Their Responses. London, England: Shaw; 1927.
12. Hynynen K, Chung AH, Colucci V, Jolesz FA. Potential adverse effects of high-intensity focused ultrasound exposure on blood vessels in vivo. Ultrasound Med Biol. 1996; 22:193-201.
13. Henderson WR. The role of leukotrienes in inflammation. Ann Intern Med 1994; 121:684-697.