Oral versus high-dose pulse corticosteroids for problematic infantile hemangiomas: A randomized, controlled trial

Pediatrics

Volumn 119, Issue 6, 2007, Pages

  Pope, Elena ^a   Krafchik, Bernice R ^a   Macarthur, Colin ^c   Stempak, Diana ^a   Stephens, Derek ^b   Weinstein, Miriam ^a   Ho, Nhung ^a   Baruchel, Sylvain ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c University of Toronto   (Canada)

Author keywords

Angiogenesis markers; Corticosteroids; Infantile hemangioma

Indexed keywords

ANGIOGENIC FACTOR; BASIC FIBROBLAST GROWTH FACTOR; CELL ADHESION MOLECULE; CORTICOSTEROID; ENDOGLIN; METHYLPREDNISOLONE; PREDNISOLONE; STEROID; VASCULOTROPIN;

ABDOMINAL PAIN; ADVERSE OUTCOME; ANGIOGENESIS; APATHY; ARTICLE; CHICKENPOX; CHILDHOOD CANCER; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CONVALESCENCE; CORTICOSTEROID THERAPY; CRYING; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG MEGADOSE; DRUG SAFETY; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH RETARDATION; HEMANGIOMA; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYPERACTIVITY; HYPERTENSION; INFANCY; INFANT; INSOMNIA; IRRITABILITY; MALE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN URINE LEVEL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY DISTRESS; SIDE EFFECT; TREATMENT DURATION; TREATMENT PLANNING; VISUAL ANALOG SCALE; VISUAL IMPAIRMENT; VOMITING;

ADMINISTRATION, ORAL; ADRENAL CORTEX HORMONES; BIOLOGICAL MARKERS; FEMALE; HEMANGIOMA; HUMANS; HYPERTENSION; INFANT; INJECTIONS, INTRAVENOUS; MALE; PAIN MEASUREMENT; RESPIRATORY DISTRESS SYNDROME, ADULT; VASCULAR CELL ADHESION MOLECULE-1;

EID: 34249903862     PISSN: 00314005     EISSN: 02105721     Source Type: Journal    
DOI: 10.1542/peds.2006-2962     Document Type: Article

References (31)

1. Wahrman JE, Honig PJ. Hemangiomas. Pediatr Rev. 1994;15: 266-271
2. Frieden IJ, Eichenfield LF, Esterly NB, Geronemus R, Mallory SB. Guidelines of care for hemangiomas of infancy. American Academy of Dermatology Guidelines/Outcomes Committee. J Am Acad Dermatol. 1997;37:631-637
3. Drolet BA, Esterly NB, Frieden IJ. Hemangiomas in children. N Engl J Med. 1999;341:173-181
4. Enjolras O, Mulliken JB. Vascular tumors and vascular malformations (new issues). Adv Dermatol. 1997;13:375-423
5. Amir J, Metzker A, Krikler R, Reisner SH. Strawberry hemangioma in preterm infants. Pediatr Dermatol. 1986;3:331-332
6. Achauer BM, Chang CJ, VanderKam VM, Boyko A. Management of hemangioma of infancy: review of 245 patients. Plast Reconstr Surg. 1997;99:1301-1308
7. Takahashi K, Mulliken JB, Kozakewich HP, Rogers RA, Folkman J, Ezekowitz RA. Cellular markers that distinguish the phases of hemangioma during infancy and childhood. J Clin Invest. 1994;93:2357-2364
8. Hasan Q, Tan ST, Gush J, Peters SG, Davis PF. Steroid therapy of a proliferating hemangioma: histochemical and molecular changes. Pediatrics. 2000;105:117-120
9. Szymik-Kantorowicz S, Partyka L, Dembinska-Kiec A, Zdzienicka A. Vascular endothelial growth factor in monitoring therapy of hepatic haemangioendothelioma. Med Pediatr Oncol. 2003;40:196-197
10. Zhang L, Lin X, Wang W, Zhuang X, et al. Circulating level of vascular endothelial growth factor in differentiating hemangioma from vascular malformation patients. Plast Reconstr Surg. 2005;116:200-204
11. Enjolras O. Management of hemangiomas. Dermatol Nurs. 1997;9:11-17
12. Enjolras O, Riche MC, Merland JJ, Escande JP. Management of alarming hemangiomas in infancy: a review of 25 cases. Pediatrics. 1990;85:491-498
13. Sadan N, Sade J, Grunebaum M. The treatment of subglottic hemangiomas of infants with prednisone. Int J Pediatr Otorhinolaryngol. 1982;4:7-14
14. Sadan N, Wolach B. Treatment of hemangiomas of infants with high doses of prednisone. J Pediatr. 1996;128:141-146
15. Bennett ML, Fleischer AB Jr, Chamlin SL, Frieden IJ. Oral corticosteroid use is effective for cutaneous hemangiomas: an evidence-based evaluation. Arch Dermatol. 2001;137:1208-1213
16. Gozal D, Saad N, Bader D, Berger A, Jaffe M. Diffuse neonatal haemangiomatosis: successful management with high dose corticosteroids. Eur J Pediatr. 1990;149:321-324
17. Enjolras O, Mulliken JB. The current management of vascular birthmarks. Pediatr Dermatol. 1993;10:311-313
18. Boon LM, MacDonald DM, Mulliken JB. Complications of systemic corticosteroid therapy for problematic hemangioma. Plast Reconstr Surg. 1999;104:1616-1623
19. Klein-Gitelman MS, Pachman LM. Intravenous corticosteroids: adverse reactions are more variable than expected in children. J Rheumatol. 1998;25:1995-2002
20. Ozsoylu S. Megadose methylprednisolone for diffuse infantile haemangiomatosis. Eur J Pediatr. 1992;151:389
21. Ozsoylu S. Oral megadose methylprednisolone for the treatment of giant hemangiomas. J Pediatr Hematol Oncol. 1995; 17:85
22. Ozsoylu S. Megadose methylprednisolone for Kasabach-Merritt syndrome. Eur J Pediatr. 2003;162:562-564
23. McGrath PA, Seifert CE, Speechley KN, Booth JC, Stitt L, Gibson MC. A new analogue scale for assessing children's pain: an initial validation study. Pain. 1996;64:435-443
24. McCormack HM, Horne DJ, Sheather S. Clinical applications of visual analogue scales: a critical review. Psychol Med. 1988;18: 1007-1019
25. Haggstrom AN, Lammer EJ, Schneider RA, Marcucio R, Frieden IJ. Patterns of infantile hemangiomas: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006;117:698-703
26. Uysal KM, Olgun N, Erbay A, Sarialioglu F. High-dose oral methylprednisolone therapy in childhood hemangiomas. Pediatr Hematol Oncol. 2001;18:335-341
27. Verkarre V, Patey-Mariaud dS, Vazeux R, et al. ICAM-3 and E-selectin endothelial cell expression differentiate two phases of angiogenesis in infantile hemangiomas. J Cutan Pathol. 1999; 26:17-24
28. Bielenberg DR, Bucana CD, Sanchez R, Mulliken JB, Folkman J, Fidler IJ. Progressive growth of infantile cutaneous hemangiomas is directly correlated with hyperplasia and angiogenesis of adjacent epidermis and inversely correlated with expression of the endogenous angiogenesis inhibitor, IFN-beta. Int J Oncol. 1999;14:401-408
29. Tan ST, Velickovic M, Ruger BM, Davis PF. Cellular and extracellular markers of hemangioma. Plast Reconstr Surg. 2000; 106:529-538
30. George ME, Sharma V, Jacobson J, Simon S, Nopper AJ. Adverse effects of systemic glucocorticosteroid therapy in infants with hemangiomas. Arch Dermatol. 2004;140:963-969
31. Thedenat B, Leaute-Labreze C, Boralevi F, et al. Blood pressure monitoring in infants with hemangiomas treated with corticosteroids [in French]. Ann Dermatol Venereol. 2002;129:183-185