Curvature-adjusted optimal design of sampling times for the inference of pharmacokinetic compartment models

Statistics in Medicine

Volumn 26, Issue 14, 2007, Pages 2799-2812

  Daimon, Takashi ^a   Goto, Masashi ^b  

^a UNIVERSITY OF SHIZUOKA   (Japan)

^b Non Profit Organization Biostatistical Research Association   (Japan)

Author keywords

D optimality; Intrinsic nonlinearity; Linearized approximation; Mean squared error; Nonlinear experimental design; Parameter effects nonlinearity; Reparameterization

Indexed keywords

DRUG;

ARTICLE; COMPARTMENT MODEL; DRUG BLOOD LEVEL; MATHEMATICAL PARAMETERS; NONLINEAR SYSTEM; SAMPLE SIZE; SAMPLING;

BIOLOGICAL AVAILABILITY; HUMANS; JAPAN; MODELS, STATISTICAL; PHARMACOKINETICS; RESEARCH DESIGN; SAMPLING STUDIES;

EID: 34249902289     PISSN: 02776715     EISSN: 10970258     Source Type: Journal    
DOI: 10.1002/sim.2736     Document Type: Article

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