Oral Administration of Avocado Soybean Unsaponifiables (ASU) Reduces Ischemic Damage in the Rat Hippocampus

Archives of Medical Research

Volumn 38, Issue 5, 2007, Pages 489-494

  Yaman, Mehmet ^a   Eser, Olcay ^a   Cosar, Murat ^a   Bas, Orhan ^a   Sahin, Onder ^a   Mollaoglu, Hakan ^a   Fidan, Huseyin ^a   Songur, Ahmet ^a  

^a AFYON KOCATEPE UNIVERSITY   (Turkey)

Author keywords

ASU; Cerebral Ischemia Reperfusion; Hippocampus

Indexed keywords

CATALASE; MALONALDEHYDE; NITRIC OXIDE; PIASCLEDINE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN ISCHEMIA; CAUTERIZATION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; FEMALE; HIPPOCAMPUS; HISTOPATHOLOGY; NONHUMAN; RAT;

ADMINISTRATION, ORAL; ANIMALS; ANTIOXIDANTS; APOPTOSIS; BRAIN ISCHEMIA; CATALASE; FEMALE; HIPPOCAMPUS; IN SITU NICK-END LABELING; MALONDIALDEHYDE; NITRIC OXIDE; OXIDATIVE STRESS; PERSEA; PHYTOTHERAPY; PLANT OILS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SOYBEANS; SUPEROXIDE DISMUTASE;

EID: 34249901299     PISSN: 01884409     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.arcmed.2007.01.008     Document Type: Article

References (25)

1. 3 on cerebral ischemia in rats. Neurosci Lett 374 (2005) 92-97
2. Lanselot E., Callebert J., Revaud M.L., Boulu R.G., and Plotkine M. Detection of hydroxyl radicals in rat striatum during transient focal cerebral ischemia: Possible implication in tissue damage. Neurosci Lett 197 (1995) 85-88
3. Chan P.H. Reactive oxygen radicals in signalingand damage in the ischemic brain. J Cereb Blood Flow Metab 21 (2001) 2-14
4. Ginsberg M.D. Neuroprotection in brain ischemia: an update (parts 1 and 2). Neuroscientist 1 (1995) 95
5. Cao W., Carney J.M., Duchon A., Floyd R.A., and Chevion M. Oxygen free radicals involvement in ischemia and reperfusion injury to brain. Neurosci Lett 88 (1998) 233-238
6. Henrotin Y.E., Labasse A.H., Jaspar J.M., de Groote D.D., Zheng S.X., Guillou G.B., et al. Effects of three avocado/soybean unsaponifiable mixtures on metalloproteinases, cytokines and prostaglandin E2 production by human articular chondrocytes. Clin Rheumatol 17 (1998) 31-39
7. Mauviel A., Loyau G., and Pujol J.P. Effet des insaponifiables d'avocat/soja (Piasclé dine) sur l'activité collagé nolytique de cultures de synoviocytes rhumatoides humains et de chondrocytes articulaires de lapin traite's par l'interleukine-1. Rev Rhum 58 (1991) 241-245
8. Maheu E., Mazieres B., Valat J.P., Loyau G., le Loet X., Bourgeois P., et al. Symptomatic efficacy of avocado/soybean unsaponifiables in the treatment of osteoarthritis of the knee and hip. A prospective, randomized, double-blind, placebo-controlled, multicenter clinical trial with six-month treatment period and a two-month followup demonstrating a persistent effect. Arthritis Rheum 41 (1998) 81-91
9. Onem G., Aral E., Enli Y., Oguz E.O., Coskun E., Aybek H., et al. Neuroprotective effects of L-carnitine and vitamin E alone or in combination against ischemia-reperfusion injury in rats. J Surg Res 131 (2006) 124-130
10. Lowry O.H., Rosenbrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
11. Wasowicz W., Neve J., and Peretz A. Optimized steps in fluorometric determination of thiobarbituric acid-reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem 39 (1993) 2522-2526
12. Cortas N.K., and Wakid N.W. Determination of inorganic nitrate in serum and urine by a kinetic cadmium-reduction method. Clin Chem 36 (1990) 1440-1443
13. Sun Y., Oberley L.W., and Ying L. A simple method for clinical assay of superoxide dismutase. Clin Chem 34 (1988) 497-500
14. Durak I., Yurtarslani Z., Canbolat O., and Akyol O. A methodological approach to superoxide dismutase (SOD) activity assay based on inhibition of nitroblue tetrazolium (NBT) reduction. Clin Chim Acta 214 (1993) 103-104
15. Aebi H. Catalase. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis (1974), Academic Press, New York 673-677
16. Read J.S., Hirano T., Davis S.M., and Donnan G.A. Limiting neurological damage after stroke. Drugs Aging 14 (1999) 11-39
17. Gutteridge J.M. Lipid peroxidation and antioxidants as biomarkers of tissue damage. Clin Chem 41 (1995) 1819-1828
18. White B.C., Grossman L.I., and Krause G.S. Brain injury by global ischemia and reperfusion: a theoretical perspective on membrane damage and repair. Neurology 43 (1993) 1656-1665
19. Sinet P.M., Heikkila R.E., and Cohen G. Hydrogen peroxide production by rat brain in vivo. J Neurochem 34 (1980) 1421-1428
20. Mebmer U.K., and Brune B. NO in apoptotic versus necrotic RAW 264.7 macrophage cell death: the role of NO-donor exposure, NAD content, and p53 accumulation. Arch Biochem Biophys 327 (1996) 1-10
21. Bosca L., and Hortelano S. Mechanisms of NO-dependent apoptosis: involvement of mitochondrial mediators. Cell Signal 11 (1999) 239-244
22. Mazieres B., Tempesta C., Thiechard M., and Vaguier G. Pathologic and biochemical effects of a lipidic avocado and soy extract (LASE) on an experimental post-contusive model of OA. Osteoarthritis Cart 1 (1993) 46-47
23. Blotman F., Maheu E., Wulwik A., Caspard H., and Lopez A. Efficacy and safety of avocado/soybean unsaponifiables in the treatment of symptomatic osteoarthritis of the knee and hip. A prospective, multicenter, threemonth, randomized, double-blind, placebo-controlled trial. Rev Rhum 64 (1997) 825-834
24. Lequesne M., Maheu E., Cadet C., Caspard H., and Dreiser R.L. Effect of avocado/soya unsaponifiables (ASU) on joint space loss in hip osteoarthritis (HOA) over 2 years. A placebo controlled trial. Arthritis Rheum 39 Suppl 9 (1996) S227
25. Ojewole J.A.O., and Amabeoku G.J. Anticonvulsant effect of Persea americana Mill (Lauraceae) (avocado) leaf aqueous extract in mice. Phytother Res 20 (2006) 696-700