Enhancement of the antimalarial efficacy of amodiaquine by chlorpheniramine in vivo

Memorias do Instituto Oswaldo Cruz

Volumn 102, Issue 3, 2007, Pages 417-419

  Sowunmi, Akintunde ^a   Gbotosho, Grace O ^a   Happi, Christian T ^a   Adedeji, Ahmed A ^a   Bolaji, Olayinka M ^a   Fehintola, Fatai A ^a   Fateye, Babasola A ^a   Oduola, Ayoade M J ^a  

^a UNIVERSITY OF IBADAN   (Nigeria)

Author keywords

Amodiaquine; Children; Chlorpheniramine; Malaria; Resistance reversal

Indexed keywords

PLASMODIUM FALCIPARUM;

EID: 34249891377     PISSN: 00740276     EISSN: 16788060     Source Type: Journal    
DOI: 10.1590/s0074-02762007005000038     Document Type: Article

References (10)

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2. Happi CT, Gbotosho GO, Folarin OA, Akinboye DO, Yusuf BO, Ebong, OO, Sowunmi A, Kyle DE, Milhous W, Wirth DF, Oduola AMJ 2005. Polymorphisms in Plasmodium falciparum dhfr and dhps genes and age related in vivo sulfadoxine-pyrimethamine resistance in malaria-infected patients from Nigeria. Acta Trop 95: 183-193.
3. Happi CT, Gbotosho GO, Folarin OA, Bolaji OM, Sowunmi A, Kyle DE, Milhous WK, Wirth DF, Oduola AMJ 2006. Association between mutations in Plasmodium falciparum chloroquine resistance transporter and P. falciparum multidrug resistance1 genes and in vivo amodiaquine resistance in P. falciparum malaria-infected children in Nigeria. Am J Trop Med Hyg 75: 155-161.
4. Happi CT, Gbotosho GO, Sowunmi A, Falade CO, Akinboye DO, Hudson T, Gerena L, Kyle DE, Milhous W, Wirth DF, Oduola AMJ 2004. Molecular analysis of Plasmodium falciparum recrudescent malaria infections in children treated with chloroquine in Nigeria. Am J Trop Med Hyg 70: 20-26.
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7. Sowunmi A, Oduola AMJ, Ogundahunsi OAT, Falade CO, Gbotosho GO, Salako LA 1997. Enhanced efficacy of chloroquine-chlorpheniramine combination in acute uncomplicated falciparum malaria in children. Trans R Soc Trop Med Hyg 91: 63-67.
8. Sowunmi A, Oduola AMJ, Ogundahunsi OAT, Salako LA 1998a. Enhancement of the antimalarial effect of chloroquine by chlorpheniramine in vivo. Trop Med Inter Hlth 3: 177-183.
9. Sowunmi A, Oduola AMJ, Ogundahunsi OAT. Salako LA 1998 b. Comparative efficacy of chloroquine plus chlorpheniramine and pyrimethamine/sulphadoxine in acute uncomplicated falciparum malaria in Nigerian children. Trans R Soc Trop Med Hyg 92: 77-81.
10. Sowunmi A, Ayede AI, Falade AG, Ndikum VN, Sowunmi CO, Adedeji AA, Falade CO, Happi TC, Oduola AMJ 2001. Randomized comparison of chloroquine and amodiaquine in the treatment of acute, uncomplicated, Plasmodium falciparum malaria in children. Ann Trop Med Parasitol 95: 549-558.