Expression of CD147 and monocarboxylate transporters MCT1, MCT2 and MCT4 in porcine small intestine and colon

Veterinary Journal

Volumn 174, Issue 1, 2007, Pages 122-128

  Sepponen, K ^a   Ruusunen, M ^a   Pakkanen, J A ^a   Poso A R ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

CD147; Colon; MCT; Pig; Small intestine

Indexed keywords

CD147 ANTIGEN; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 2; MONOCARBOXYLATE TRANSPORTER 4; SHORT CHAIN FATTY ACID;

ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; BREED DIFFERENCE; COLON; CONTROLLED STUDY; FEMALE; IMMUNOBLOTTING; MALE; NONHUMAN; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; SMALL INTESTINE; SWINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD147; FEMALE; INTESTINAL ABSORPTION; INTESTINE, SMALL; MALE; MOLECULAR SEQUENCE DATA; MONOCARBOXYLIC ACID TRANSPORTERS; SWINE;

SUIDAE; SUS;

EID: 34249888756     PISSN: 10900233     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tvjl.2006.05.015     Document Type: Article

References (33)

1. Argenzio R.A., and Southworth M. Sites of organic acid production and absorption in the gastrointestinal tract of the pig. American Journal of Physiology 228 (1974) 454-460
2. Bergersen L., Wærhaug O., Helm J., Thomas M., Laake P., Davies A.J., Wilson M.C., Halestrap A.P., and Ottersen O.P. A novel postsynaptic density protein: the monocarboxylate transporter MCT2 is co-localized with δ-glutamate receptors in postsynaptic densities of parallel fiber-Purkinje cell synapses. Experimental Brain Research 136 (2001) 523-534
3. Bergman E.N. Energy contributions of volatile fatty acids from the gastrointestinal tract in various species. Physiological Reviews 70 (1990) 567-583
4. Binder H.J., and Mehta P. Short-chain fatty acids stimulate active sodium and chloride absorption in vitro in the rat distal colon. Gastroenterology 96 (1989) 989-996
5. Bröer S., Schneider H.P., Bröer A., Rahman B., Hamprecht B., and Deitmer J.W. Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochemical Journal 333 (1998) 167-174
6. Bröer S., Bröer A., Schneider H.P., Stegen C., Halestrap A.P., and Deitmer J.W. Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochemical Journal 341 (1999) 529-535
7. Buyse M., Sitaraman S.V., Liu X., Bado A., and Merlin D. Luminal leptin enhances CD147/MCT-1-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. Journal of Biological Chemistry 31 (2002) 28182-28190
8. +-monocarboxylate cotransporter. The Journal of Physiology 557 (2004) 719-731
9. Dimmer K.S., Friedrich B., Lang F., Deitmer J.W., and Bröer S. The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells. Biochemical Journal 350 (2000) 219-227
10. Fishbein W.N., Merezhinskaya N., and Foellmer J.W. Relative distribution of three major lactate transporters in frozen human tissues and their localization in unfixed skeletal muscle. Muscle & Nerve 26 (2002) 101-112
11. Garcia C.K., Brown M.S., Pathak R.K., and Goldstein J.L. cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. Journal of Biological Chemistry 270 (1995) 1843-1849
12. Hadjiagapiou C., Schmidt L., Dudeja P.K., Layden T.J., and Ramaswamy K. Mechanism(s) of butyrate transport in Caco-2 cells: role of monocarboxylate transporter 1. American Journal of Physiology (Gastrointestinal and Liver Physiology) 279 (2000) G775-G780
13. Halestrap A.P., and Meredith D. The SLC16 gene family - from monocarboxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflügers Archiv - European Journal of Physiology 447 (2003) 619-628
14. Halestrap A.P., and Price N.T. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochemical Journal 343 (1999) 281-299
15. Jackson V.N., and Halestrap A.P. The kinetics, substrate & inhibitor specificity of the monocarboxylate (lactate) transporter of rat liver cells determined using the fluorescent intracellular pH indicator, 2′,7′-bis(carboxyethyl)-5(6)-carboxyfluorescein. Journal of Biological Chemistry 271 (1996) 861-868
16. Jackson V.N., Price N.T., Carpenter L., and Halestrap A.P. Cloning of the monocarboxylate transporter isoform MCT2 from rat testis provides evidence that expression in tissues is species-specific and may involve post-translational regulation. Biochemical Journal 324 (1997) 447-453
17. Juel C., and Halestrap A.P. Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter. Journal of Physiology 517 (1999) 633-642
18. Kirk P., Wilson M.C., Heddle C., Brown M.H., Barclay A.N., and Halestrap A.P. CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. The EMBO Journal 19 (2000) 3896-3904
19. Koho N.M., Väihkönen L.K., and Pösö A.R. Lactate transport in red blood cells by monocarboxylate transporters. Equine Veterinary Journal, Supplement 34 (2002) 555-559
20. Lucas M.L., and Blair J.A. The magnitude and distribution of the acid microclimate in proximal jejunum and in relation to luminal acidification. Proceedings of the Royal Society of London 200 (1978) 27-41
21. Manning Fox J.E., Meredith D., and Halestrap A.P. Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. Journal of Physiology 529 (2000) 285-293
22. Merezhinskaya N., Fishbein W.N., Davis J.I., and Foellmer W. Mutations in MCT1 cDNA in patients with symptomatic deficiency in lactate transport. Muscle & Nerve 23 (2000) 90-97
23. Ritzhaupt A., Elli A., Hosie K.B., and Shirazi-Beechey S.P. The characterization of butyrate transport across pig and human colonic luminal membrane. Journal of Physiology 507 (1998) 819-830
24. Ritzhaupt A., Wood I.S., Ellis A., Hosie K.B., and Shirazi-Beechey S.P. Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport l-lactate as well as butyrate. Journal of Physiology 513 (1998) 719-732
25. Scheppach W., Sommer H., Kirchner T., Paganelli G.-M., Bartram P., Christl S., Richter F., Dusel G., and Kasper H. Effect of butyrate enemas on the colonic mucosa in distal ulcerative colitis. Gastroenterology 103 (1992) 51-56
26. Schröder O., Opritz J., and Stein J. Substrate and inhibitor specificity of butyrate uptake in apical membrane vesicles of the rat distal colon. Digestion 62 (2000) 152-158
27. Sepponen K., Koho N., Puolanne E., Ruusunen M., and Pösö A.R. Distribution of monocarboxylate transporter isoforms MCT1, MCT2 and MCT4 in porcine muscles. Acta Physiologica Scandinavica 177 (2003) 79-86
28. Takanaga H., Tamai I., Inaba S., Sai Y., Higashida H., Yamamoto H., and Tsuji A. cDNA cloning and functional characterization of rat intestinal monocarboxylate transporter. Biochemical and Biophysical Research Communications 217 (1995) 370-377
29. Tamai I., Takanaga H., Maeda H., Sai Y., Ogihara T., Higashida H., and Tsuji A. Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochemical and Biophysical Research Communications 214 (1995) 482-489
30. Väihkönen L.K., and Pösö A.R. Interindividual variation in total and carrier-mediated lactate influx into red blood cells. American Journal of Physiology (Regulative and Integrative Comparative Physiology) 274 (1998) R1025-R1030
31. Väihkönen L.K., Ojala M., and Pösö A.R. Age-related changes and inheritance of lactate transport activity in red blood cells. Equine Veterinary Journal, Supplement 34 (2002) 568-572
32. Wilson M.C., Meredith D., Manning Fox J.E., Manoharan C., Davies A.J., and Halestrap A.P. Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is Embigin (gp70). Journal of Biological Chemistry 280 (2005) 27213-27221
33. Wächtershäuser A., and Stein J. Rationale for the luminal provision of butyrate in intestinal diseases. European Journal of Nutrition 39 (2000) 164-171