Development, evaluation and application of an isocratic high-performance liquid chromatography (HPLC) assay for the simultaneous determination of aciclovir and its metabolite 9-carboxymethoxymethylguanine in human serum and cerebrospinal fluid

International Journal of Antimicrobial Agents

Volumn 30, Issue 1, 2007, Pages 30-33

  Darville, J M ^a   Lovering, A M ^a   MacGowan, A P ^a  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

Author keywords

9 Carboxymethoxymethylguanine; Aciclovir; HPLC

Indexed keywords

9 CARBOXYMETHOXYMETHYLGUANINE; ACICLOVIR; DRUG METABOLITE; UNCLASSIFIED DRUG;

ARTICLE; BODY FLUID; CEREBROSPINAL FLUID; DRUG BLOOD LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ACYCLOVIR; ANALYSIS OF VARIANCE; CEREBROSPINAL FLUID; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GUANINE; HUMANS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SERUM;

EID: 34249886303     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2007.02.005     Document Type: Article

References (8)

1. Elion G.B. Acyclovir: discovery, mechanism of action, and selectivity. J Med Virol Suppl. 1 (1993) 2-6
2. Wade J.C., and Meyers J.D. Neurologic symptoms associated with parenteral acyclovir treatment after marrow transplantation. Ann Intern Med 98 (1983) 921-925
3. de Miranda P., and Burnette T.C. Metabolic fate and pharmacokinetics of the acyclovir prodrug valaciclovir in cynomolgus monkeys. Drug Metab Dispos 22 (1994) 55-59
4. Helldén A., Odar-Cederlof I., Diener P., et al. High serum concentrations of the acyclovir main metabolite 9-carboxymethoxymethylguanine in renal failure patients with acyclovir-related neuropsychiatric side effects: an observational study. Nephrol Dial Transplant 18 (2003) 1135-1141
5. Haas D.W., Weller S., Johnson B., et al. CSF penetration of acyclovir (ACV) and its metabolites after high dose valacyclovir (VACV) administration. Abstracts of the 43rd Interscience conference on antimicrobial agents and chemotherapy. American Society for Microbiology (Chicago, IL), 14-17 September (2003) 40 abstract A-1796
6. Helldén A., Lycke J., Vander T., Svensson J.O., Odar-Cedarlof I., and Stahle L. The acyclovir metabolite CMMG is detectable in the CSF of subjects with neuropsychiatric symptoms during aciclovir and valaciclovir treatment. J Antimicrob Chemother 57 (2006) 945-949
7. McMullin C.M., Kirk B., Sunderland J., et al. A simple high performance liquid chromatography (HPLC) assay for aciclovir and ganciclovir in serum. J Antimicrob Chemother 38 (1996) 739-740
8. Svensson J.-O., Barkholt L., and Sawe J. Determination of acyclovir and its metabolite 9-carboxymethoxymethylguanine in serum and urine using solid-phase extraction and high-performance liquid chromatography. J Chromatogr 690 (1996) 363-366