Adjuvant therapy for pancreatic cancer: No 'definite' standard

ONCOLOGY

Volumn 21, Issue 6, 2007, Pages 726-730

  Garofalo, Michael C ^a   Abrams, Ross A ^b   Regine, William F ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b RUSH UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; GEMCITABINE;

CANCER ADJUVANT THERAPY; CANCER SURVIVAL; CHEMOSENSITIZATION; CLINICAL PROTOCOL; HUMAN; METASTASIS; MONOTHERAPY; OUTCOMES RESEARCH; PANCREAS CANCER; QUALITY CONTROL; REVIEW; STANDARD; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 34249883906     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (20)

1. Neoptolemos JP, Dunn JA, Stocken DD, et al: Adjuvant chemoradiotherapy and chemotherapy in respectable pancreatic cancer: A randomized controlled trial. Lancet 358:1576-1585, 2001.
2. Neoptolemos JP, Stocken DD, Friess F, et al: A randomized trial of chemoradiotherapy and chemotherapy after resection of pancreatic cancer. N Engl J Med 350:1200-1210, 2004.
3. Oettle H, Post S, Neuhaus P, et al: Adjuvant chemotherapy with gemcitabine vs observation in patients undergoing curative-intent resection of pancreatic cancer. JAMA 297:267-277, 2007.
4. Choti MA: Adjuvant therapy for pancreatic cancer - the debate continues. N Engl J Med 350:1249-1251, 2004.
5. Morris SL, Beasley M, Leslie M: Chemotherapy for pancreatic cancer [letter to the editor]. N Engl J Med 350:2713, 2004.
6. Crane CH, Ben-Josef E, Small W: Chemotherapy for pancreatic cancer [letter to the editor]. N Engl J Med 350:2713-2714, 2004.
7. Bydder S, Spry N: Chemotherapy for pancreatic cancer [letter to the editor]. N Engl J Med 350:2714, 2004.
8. Gastrointestinal Tumor Study Group: Further evidence of effective adjuvant combined radiation and chemotherapy following curative resection of pancreatic cancer. Cancer 59:2006-2010, 1987.
9. Klinkenbijl JH, Jeekel J, Sahmoud T, et al: Adjuvant radiotherapy and 5-fluorouracil after curative resection of cancer of the pancreas and periampullary region: A phase III trial of the EORTC gastrointestinal tract cancer cooperative group. Ann Surg 230:776-782, 1999.
10. Garofalo MC, Regine WR, Tan MT: On statistical reanalysis, the EORTC trial is a positive trial for adjuvant chemoradiation in pancreatic cancer. Ann Surg 244:332-333, 2006.
11. Bakkevold K, Arnesjo B, Dahl O, et al: Adjuvant combination chemotherapy (AMF) following radical resection of carcinoma of the pancreas and papilla of Vater - results of a controlled, prospective, randomized multicentre study. Eur J Cancer 29A:698-703, 1993.
12. Takada T, Amano H, Yasuda H, et al: Is postoperative adjuvant chemotherapy useful for gall bladder carcinoma? A phase III multicentre prospective randomized controlled trial in patients with resected pancreaticobiliary carcinoma. Cancer 95:1685-1695, 2002.
13. Regine WF, Winter KA, Abrams R, et al: RTOG 9704: A phase III study of adjuvant pre- and post-chemoradiation 5-FU versus gemcitabine for resected pancreatic adenocarcinoma (abstract 4007). J Clin Oncol 24(18S):180s, 2006.
14. Abrams RA, Winter KA, Regine WF, et al: Radiotherapy quality assurance review and survival. Proceedings of ASTRO. Int J Radiat Oncol Biol Phys 66:S22, 2006.
15. Burris III HA, Moore MJ, Anderson J, et al: Improvements in survival and clinical benefit with gemcitabine as first-line therapy for patients with advanced pancreas cancer: A randomized trial. J Clin Oncol 15:2403-2413, 1997.
16. Moertel CG, Frytak S, Hang RG, et al: Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil) and high dose radiation + 5-fluorouracil. Cancer 48:1705-1710, 1981.
17. Moertel CG, Childs DS, Reitemeier RJ, et al: Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer. Lancet 2(3627):865-867, 1969.
18. Childs DS, Moertel CG, Holbrook MA, et al: Treatment of malignant neoplasms of the gastrointestinal tract with a combination of 5-fluorouracil and radiation: A randomized double-blind study. Radiology 84:843-848, 1965.
19. Heidelberger C, Griesbach L, Montag BJ, et al: Studies on fluorinated pyrimidines II. Effects on transplanted tumors. Cancer Res 18:305-317, 1958.
20. Gastrointestinal Tumor Study Group: Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone. J Natl Cancer Inst 80:751-755, 1988.