Optimization of hyperthermic intraperitoneal chemotherapy with oxaliplatin plus irinotecan at 43°C after compete cytoreductive surgery: Mortality and morbidity in 106 consecutive patients

Annals of Surgical Oncology

Volumn 14, Issue 6, 2007, Pages 1818-1824

  Elias, Dominique ^a   Goere, Diane ^a   Blot, François ^a   Billard, Valérie ^a   Pocard, Marc ^a   Kohneh Shahri, Niaz ^a   Raynard, Bruno ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

Cytoreductive surgery; Hyperthermia; Intraperitoneal chemotherapy; Irinotecan; Morbidity; Mortality; Oxaliplatin; Peritoneal carcinomatosis

Indexed keywords

ANTIBIOTIC AGENT; FLUOROURACIL; FOLINIC ACID; GLUCOSE; IRINOTECAN; OXALIPLATIN;

ABDOMINAL ABSCESS; ADOLESCENT; ADULT; AGED; APLASIA; ARTICLE; BLEEDING; BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER MORTALITY; CANCER SURGERY; CANCER SURVIVAL; CARCINOMATOUS PERITONITIS; CATHETER INFECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOREDUCTIVE SURGERY; DIGESTIVE SYSTEM FISTULA; FEMALE; HIGH TEMPERATURE; HUMAN; HYPERTHERMIC THERAPY; KIDNEY FAILURE; LUNG INFECTION; MAJOR CLINICAL STUDY; MALE; MORBIDITY; OPERATION DURATION; OUTCOME ASSESSMENT; PANCREAS FISTULA; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PROSPECTIVE STUDY; SCORING SYSTEM; UNSPECIFIED SIDE EFFECT; URINARY TRACT FISTULA; URINARY TRACT INFECTION;

ADOLESCENT; ADULT; AGED; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BLOOD LOSS, SURGICAL; CAMPTOTHECIN; CARCINOMA; DNA TOPOISOMERASES, TYPE I; FEMALE; FLUOROURACIL; HUMANS; HYPERTHERMIA, INDUCED; INJECTIONS, INTRAPERITONEAL; LEUCOVORIN; MALE; MIDDLE AGED; NEOADJUVANT THERAPY; ORGANOPLATINUM COMPOUNDS; PERITONEAL NEOPLASMS; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; SURVIVAL RATE; VITAMIN B COMPLEX;

EID: 34249870366     PISSN: 10689265     EISSN: 15344681     Source Type: Journal    
DOI: 10.1245/s10434-007-9348-1     Document Type: Article

References (35)

1. Sugarbaker PH, Cuniffe W, Belliveau JF, de Bruin E, Graves T. Rationale for perioperative intraperitoneal chemotherapy as a surgical adjuvant for gastrointestinal malignancy. Reg Cancer Treat 1988;1:66-79
2. Sugarbaker PH, Schellinx ME, Chang D, Koslowe P, von Meyerfeldt M. Peritoneal carcinomatosis from adenocarcinoma of the colon. World J Surg 1996;20:585-92
3. Fujimoto S, Shresta RD, Kokubun M, et al. Positive results of combined therapy of surgery and intraperitoneal hyperthermic perfusion for far advanced gastric cancer. Ann Surg 1990;212:592-6
4. Elias D, Blot F, El Otmany A, et al. Curative treatment of peritoneal carcinomatosis arising from colorectal cancer by complete resection and intraperitoneal chemotherapy. Cancer 2001;92:71-6
5. Los G, Mutsaers PH, van der Vijgh WJ, Baldew GS, de Graaf PW, McVie JG. Direct diffusion of cisplatinum in intraperitoneal rat tumors after intraperitoneal chemotherapy: a comparison with systemic chemotherapy. Cancer Res 1989;48:3380-4
6. Zoetmulder FA. Cancer cell seeding during abdominal surgery: experimental studies. In: Sugarbaker PH, ed. Peritoneal Carcinomatosis: Principles of Management. Boston: Kluwer Acadademic Publishers, 1996:155-62
7. Jacquet P, Elias D, Sugarbaker P. L'implantation tumorale dans les sites de cicatrisation après chirurgie des cancers digestifs. J Chir (Paris) 1996;133:175-82
8. Elias D, Ouellet JF. Intraperitoneal chemohyperthermia. Rationale, technique, indications and results. Surg Oncol Clin N Am 2001;10:915-33
9. Ceelen WP, Hesse U, de Hemptinne B, Pattyn P. Hyperthermic intraperitoneal chemoperfusion in the treatment of locally advanced intra-abdominal cancer. Br J Surg 2000;87:1006-15
10. Rietbroeck RC, van de Vaart PJ, Haveman J, et al. Hyperthermia enhances the cytotoxicity and platinum-DNA adduct formation of lobaplatin and oxaliplatin in cultured SW 1573 cells. J Cancer Res Clin Oncol 1997;123:6-12
11. Elias D, Raynard B, Farkhondeh F, et al. Peritoneal carcinomatosis of colorectal origin: long-term results of intraperitoneal chemohyperthermia with oxaliplatin following complete cytoreductive surgery. Gastroenterol Clin Biol 2006;30:1200-4
12. Becouarn Y, Ychou M, Ducreux M, et al. Phase II trial of oxaliplatin as first line chemotherapy in metastatic colorectal cancer. J Clin Oncol 1998;16:2739-44
13. Giachetti S, Perpoint B, Zidani R, et al. Phase III multicenter randomized trial of oxaliplatin added to chronomoduled fluorouracil-leucovorin as first line treatment of metastatic colorectal cancer. J Clin Oncol 2000;18:136-47
14. De Gramont A, Figer A, Seymour M, et al. Leucovorin and fluorouracil with or without oxaliplatin as first line treatment in advanced colorectal cancer. J Clin Oncol 2000;18:2938-47
15. Sugarbaker PH. Intraperitoneal chemotherapy and cytoreductive surgery for the prevention and treatment of peritoneal carcinomatosis and sarcomatosis. Semin Surg Oncol 1998;14:254-61
16. Yonemura Y, Fujimura T, Nishimura G, et al. Effects of intraoperative chemohyperthermia in patients with gastric cancer with peritoneal dissemination. Surgery 1996;119:437-44
17. Elias D, Antoun A, Goharin A, et al. Research on the best chemohyperthermia technique for treatment of peritoneal carcinomatosis after complete resection. Int J Surg Invest 2000;1:431-9
18. Elias D, Bonnay M, Puizillou JM, et al. Heated intraoperative intraperitoneal oxaliplatin after complete resection of peritoneal carcinomatosis: pharmacokinetics and tissue distribution. Ann Oncol 2002;13:267-72
19. Le Page S, Kwiatkowski F, Paulin C, et al. In vitro thermochemotherapy of colon cancer cell lines with irinotecan alone and combined with mitomycin C. Hepatogastroenterology 2006;53:693-7
20. Rougier P, van Custem E, Bajetta E, et al. Randomized trial of irinotecan versus flourouracyl by continuous infusion after fluouracyl failure in patients with metastatic colorectal cancer. Lancet 1998;352:1407-12
21. Hribaschek A, Pross M, Kuhn R, et al. Prevention and treatment of peritoneal carcinomatosis in experimental investigations with CPT-11 or oxaliplatin. Anti-Cancer Drugs 2002;13:605-14
22. Elias D, Matsuhisa T, Sideris L, et al. Heated intra-operative intraperitoneal oxaliplatin plus irinotecan after complete resection of peritoneal carcinomatosis: pharmacokinetics, tissue distribution and tolerance. Ann Oncol 2004;15:1558-65
23. Elias D, Dube P, Bonvalot S, et al. A treatment of liver metastases with moderate peritoneal carcinomatosis by hepatectomy and cytoreductive surgery followed by immediate postoperative intraperitoneal chemotherapy. Feasibility and preliminary results. Hepatogastroenterology 1999;46:360-3
24. Elias D, Delperro JR, Sideris L, et al. Treatment of peritoneal carcinomatosis from colorectal cancer: impact of the complete cytoreductive surgery and difficulties in conducting randomized trials. Ann Surg Oncol 2004;11:518-21
25. Sugarbaker PH. Peritonectomy procedures. Ann Surg 1995;221:29-42
26. Sugarbaker PH, Stuart OA, Carmignani CP. Pharmacokinetics changes induced by the volume of chemotherapy solution in patients treated with hyperthermic intraperitoneal mitomycin C. Cancer Chemother Pharmacol 2006;57:703-8
27. Martin RC, Brennan MF, Jacques DP. Quality of complication reporting in the surgical literature. Ann Surg 2002;235:803-13
28. Verwaal V, van Ruth S, de Bree E, et al. Randomized trial of cytoreduction and hyperthermic intraperitoneal chemotherapy versus systemic chemotherapy and palliative surgery in patients with peritoneal carcinomatosis of colorectal cancer. J Clin Oncol 2003;21:3737-43
29. Glehen O, Kwiatowsky F, Sugarbaker P, et al. Cytoreductive surgery combined with intraperitoneal chemotherapy for management of peritoneal carcinomatosis from colorectal cancer: a multi-institutional study. J Clin Oncol 2004;22:3284-92
30. Elias D, Delperro JR, Sideris L, et al. Treatment of peritoneal carcinomatosis from colorectal cancer: impact of the complete cytoreductive surgery and difficulties in conducting randomized trials. Ann Surg Oncol 2004;11:518-21
31. Shimizu T, Maeta M, Koga S. Influence of local hyperthermia on the healing of small intestinal anastomosis in the rat. Br J Surg 1991;78:57-9
32. Stephens AD, Alderman R, Chang D, et al. Morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative chemotherapy using the coliseum technique. Ann Surg Oncol 1999;6:790-6
33. Glehen O, Osinsky D, Cotte E, et al. Intraperitoneal chemohyperthermia using closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures. Ann Surg Oncol 2003;10:863-9
34. Smeenk RM, Verwaal VJ, Zoetmulder FA. Toxicity and mortality of cytoreduction and intraoperative hyperthermic intraperitoneal chemotherapy in pseudomyxoma peritonei. A report of 103 procedures. Eur J Surg Oncol 2006;32:186-90
35. Elias D, Raynard B, Boige V, et al. Impact of the extent and duration of cytoreductive surgery on postoperative haematological toxicity after intraperitoneal chemohyperthermia for peritoneal carcinomatosis. J Surg Oncol 2005;90:220-5