Inducible overexpression of wild-type prion protein in the muscles leads to a primary myopathy in transgenic mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 16, 2007, Pages 6800-6805

  Huang, Shenghai ^a   Liang, Jingjing ^a   Zheng, Mengjie ^a   Li, Xinyi ^a   Wang, Meiling ^a   Wang, Ping ^a   Vanegas, Difernando ^b   Wu, Di ^a   Chakraborty, Bikram ^a   Hays, Arthur P ^c   Chen, Ken ^d   Chen, Shu G ^a   Booth, Stephanie ^e   Cohen, Mark ^f   Gambetti, Pierluigi ^a   Kong, Qingzhong ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b LERNER RESEARCH INSTITUTE   (United States)

^c NewYork Presbyterian Hospital   (United States)

^d ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^e PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^f UNIVERSITY HOSPITALS OF CLEVELAND   (United States)

Author keywords

Doxycycline; Inducible transgenic mice; Muscle disease

Indexed keywords

DOXYCYCLINE; PRION PROTEIN; PROTEINASE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DISEASE MODEL; FIBROSIS; MOUSE; MUSCLE CELL; MYOPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; TRANSGENIC MOUSE; ANIMAL; BIOSYNTHESIS; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MUSCLE DISEASE; SKELETAL MUSCLE;

MUS MUSCULUS;

ANIMALS; DOXYCYCLINE; GENE EXPRESSION REGULATION; HUMANS; MICE; MICE, TRANSGENIC; MUSCLE, SKELETAL; MUSCULAR DISEASES; PRPC PROTEINS;

EID: 34249860195     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0608885104     Document Type: Article

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