An unexpected observation concerning the effect of anionic additives on the retention behavior of basic drugs and peptides in reversed-phase liquid chromatography

Journal of Chromatography A

Volumn 1154, Issue 1-2, 2007, Pages 165-173

  Wang, Xiaoli ^a   Carr, Peter W ^b  

^a ASTRAZENECA   (United Kingdom)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Anionic additives; Basic drugs; Ion pair formation; Peptides; Retention behavior; RPLC

Indexed keywords

ACETONITRILE; LIQUID CHROMATOGRAPHY; NEGATIVE IONS; PEPTIDES; REGRESSION ANALYSIS; VOLUME FRACTION;

ANIONIC ADDITIVES; BASIC DRUGS; ION PAIR FORMATION; RETENTION BEHAVIOR;

DRUG PRODUCTS;

ACETONITRILE; AMITRIPTYLINE; DESIPRAMINE; DRUG ADDITIVE; ION; PEPTIDE; PERCHLORATE; SODIUM CHLORIDE;

ADDITION REACTION; ARTICLE; CHEMICAL MODIFICATION; DRUG RETENTION; ION PAIR EXTRACTION; IONIC STRENGTH; MAGNITUDE ESTIMATION METHOD; PRIORITY JOURNAL; REVERSED PHASE LIQUID CHROMATOGRAPHY; SODIUM RETENTION;

ACETONITRILES; ADSORPTION; AMITRIPTYLINE; ANIONS; CHROMATOGRAPHY, LIQUID; PEPTIDES; PERCHLORIC ACID; PHARMACEUTICAL PREPARATIONS; SODIUM COMPOUNDS;

EID: 34249827587     PISSN: 00219673     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chroma.2007.03.057     Document Type: Article

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