Glycine receptors contribute to cytoprotection of glycine in myocardial cells

Chinese Medical Journal

Volumn 120, Issue 10, 2007, Pages 915-921

  Qi, Ren Bin ^a   Zhang, Jun Yan ^b   Lu, Da Xiang ^a   Wang, Hua Dong ^a   Wang, Hai Hua ^c   Li, Chu Jie ^a  

^a MEDICAL COLLEGE OF JINAN UNIVERSITY   (China)

^b Children's Hospital of Shanxi   (China)

^c WANNAN MEDICAL COLLEGE   (China)

Author keywords

Cardiomyocyte; Glycine; Glycine receptor; Myocardial cell

Indexed keywords

AMINO ACID RECEPTOR; CALCIUM ION; GLYCINE; GLYCINE RECEPTOR; GLYCINE RECEPTOR ALPHA1; GLYCINE RECEPTOR BETA; LACTATE DEHYDROGENASE; LIPOPOLYSACCHARIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL PROTECTION; CONTROLLED STUDY; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART MUSCLE TENSION; HEART RATE; IMMUNOHISTOCHEMISTRY; ISOLATED HEART; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; RECEPTOR OCCUPANCY; RECEPTOR UPREGULATION; REOXYGENATION; WESTERN BLOTTING;

EID: 34249824889     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.1097/00029330-200705020-00012     Document Type: Article

References (23)

1. Rajendra S, Lynch JW, Schofield PR. The glycine receptor. Pharmacol Ther 1997; 73: 121-146.
2. Laube B, Maksay G, Schemm R, Betz H. Modulation of glycine receptor function: a novel therapeutic approach for therapeutic intervention at inhibitory synapses? Trends Pharmacol Sci 2002; 23: 519-527.
3. Pfeiffer F, Betz H. Solubilization of the glycine receptor from rat spinal cord. Brain Res 1981; 226: 273-279.
4. Werman R, Davidoff RA, Aprison MH. Is glycine a neurotransmitter? Inhibition of motoneurones by iontophoresis of glycine. Nature 1967; 214: 681-683.
5. Yamashina S, Konno A, Wheeler MD, Rusyn IV, Rusyn EL, Cox AD, Thurman RG. Endothelial cells contain a glycine-gated chloride channel. Nutr Cancer 2001; 40: 197-204.
6. Reeves WB. Effects of chloride channel blockers on hypoxic injury in rat proximal tubules. Kidney Int 1997; 51: 1529-1534.
7. Ikejima K, Iimuro Y, Forman DT, Thurman RG. A diet containing glycine improves survival in endotoxin shock in the rat. Am J Physiol 1996; 271 (1 Pt 1): G97-103.
8. Li X, Bradford BU, Wheeler MD, Stimpson SA, Pink HM, Brodie TA, et al. Dietary glycine prevents peptidoglycan polysaccharide-induced reactive arthritis in the rat: role for glycine-gated chloride channel. Infect Immun 2001; 69: 5883-5891.
9. Wheeler MD, Rose ML, Yamashima S, Enomoto N, Seabra V, Madren J, et al. Dietary glycine blunts lung inflammatory cell influx following acute endotoxin. Am J Physiol Lung Cell Mol Physiot 2000; 279: L390-L398.
10. Wheeler MD, Stachlewitz RF, Yamashina S, Ikejima K, Morrow AL, Thurman RG. Glycine-gated chloride channels in neutrophils attenuate calcium influx and superoxide production. FASEB J 2000; 14: 476-484.
11. Stachlewitz RF, Li X, Smith S, Bunzendahl H, Graves LM, Thurman RG. Glycine inhibits growth of T lymphocytes by an IL-2-independent mechanism. J Immunol 2000; 164: 176-182.
12. Qi RB, Lu D, Wang HD, Zhou H, Wang HH, Li CJ. Effect of glycine on endotoxin induce myocardial cell injury of isolated rat heart. Chin Pharmac Bull (Chin) 2005; 21: 738-741
13. Qi RB, Li XJ, Wang HD, Wang HH, Lu DX. Study of mechanism in glycine antagonizing myocardial damage. Chin J Pathophysiol (Chin) 2003; 19: 1560-1161
14. Simpson P, Savion S. Differentiation of rat myocytes in single cell cultures with and without proliferating nonmyocardial cells. Circ Res 1982; 50: 101-116.
15. Ito H, Hirata Y, Hiroe M, Tsujino M, Adachi S, Takamoto T, et al. Endothelin-1 induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes. Circ Res 1991; 69: 209-215.
16. Gundersen RY, Vaagenes P, Breivik T, Fonnum F, Opstad PK. Glycine-an important neurotransmitter and cytoprotective agent. Acta Anaesthesiologica Scandinavica 2005; 49: 1108-1116.
17. Qu W, Ikejima K, Zhong Z, Waalkes MP, Thurman RG. Glycine blocks the increase in intracellular fire Ca2+ due to vasoactive mediators in hepatic parenchymal cells. Am J Physiol Gastrointest Liver Physiol 2002; 283: G1249-G1256.
18. Miller GW, Schnellmann RG. A putative cytoprotective receptor in the kidney: relation to the neuronal strychnine-sensitive glycine receptor. Life Sci 1994; 55: 27-34.
19. Zhang Y, Ikejima K, Honda H, Kitamura T, Takei Y, Sato N. Glycine prevents apoptosis of rat sinusoidal endothelial cells caused by deprivation of vascular endothelial growth factor. Hepatology 2002; 32: 542-546.
20. Zhong Z, Wheeler MD, Li X, Froh M, Schemmer P, Yin M, et al. L-Glycine: a novel antiinflammatory, immunomodulatory, and cytoprotective agent. Curr Opin Clin Nutr Metab Care 2003; 6: 229-240.
21. Stachlewitz RF, Seabra V, Bradford BU, Bradham CA, Rusyn I, Germolec D, et al. Glycine and uridine prevent D-galactosamine hepatotoxicity in the rat: role of Kupffer cells. Hepatology 1999; 29: 737-745.
22. Lu DX, Li CJ, Fu YM, Wang HD. Inhibitory effect of glycine upon endotoxin pyrogenicity. Chin J Pathophysiol (Chin) 1996; 12: 235-238.
23. Ding Y, Wu CY, Sun W, Lu DX. Inhibitory effect of glycine on the production of monocytic IL-1 and TNF induced endotoxin. Chin Pharmac Bull (Chin) 1999; 15: 184-185.