Blood pressure modulating properties of omega-3 polyunsaturated fatty acids (PUFA): Another PUFA heart protective effect?

High Blood Pressure and Cardiovascular Prevention

Volumn 14, Issue 2, 2007, Pages 55-61

  Borghi, Claudio ^a,b   Cicero, Arrigo F G ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

^b UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Blood pressure; DHA; Docosahexaenoic acid; Eicosapentaenoic acid; EPA; Fish; Fish oil; Hypertension; Omega 3 fatty acids; Polyunsaturated fatty acids; PUFA

Indexed keywords

OMEGA 3 FATTY ACID;

ARTERY COMPLIANCE; BLOOD PRESSURE MEASUREMENT; BLOOD PRESSURE REGULATION; DIASTOLIC BLOOD PRESSURE; DIET SUPPLEMENTATION; ENDOTHELIAL DYSFUNCTION; GASTROINTESTINAL SYMPTOM; HEART INFARCTION; HEART INFARCTION PREVENTION; HEART PROTECTION; HEART RATE VARIABILITY; HUMAN; PRIORITY JOURNAL; REVIEW; RISK BENEFIT ANALYSIS; SYSTOLIC BLOOD PRESSURE; THERAPY EFFECT; TREATMENT RESPONSE; VASOMOTOR REFLEX; WEIGHT REDUCTION;

EID: 34249821943     PISSN: 11209879     EISSN: None     Source Type: Journal    
DOI: 10.2165/00151642-200714020-00001     Document Type: Review

References (52)

1. Dyerberg J, Bang HO, Hjorne N. Fatty acid composition of the plasma lipids in Greenland Eskimos. Am J Clin Nutr 1975; 28: 958-66
2. Ebbesson SO, Risica PM, Ebbesson LO, et al. Omega-3 fatty acids improve glucose tolerance and components of the metabolic syndrome in Alaskan Eskimos: the Alaska Siberia project. Int J Circumpolar Health 2005; 64 (4): 396-408
3. Skerrett PJ, Hennekens CH. Consumption of fish and fish oils and decreased risk of stroke. Prev Cardiol 2003; 1: 38-41
4. Mozaffarian D, Longstreth WT Jr, Lemaitre RN, et al. Fish consumption and stroke risk in elderly individuals: the cardiovascular health study. Arch Intern Med 2005; 165 (2): 200-6
5. Morris MC, Evans DA, Tangney CC, et al. Fish consumption and cognitive decline with age in a large community study. Arch Neurol 2005; 62 (12): 1849-53
6. Brouwer IA, Heeringa J, Geleijnse JM, et al. Intake of very long-chain n-3 fatty acids from fish and incidence of atrial fibrillation: the Rotterdam Study. Am Heart J 2006; 151 (4): 857-62
7. Kris-Etherton PM, Taylor DS, Yu-Poth S, et al. Polyunsaturated PUFAs in the food chain in the United States. Am J Clin Nutr 2000; 71: 179S-188S
8. Njelekela M, Ikeda K, Mtabaji J, et al. Dietary habits, plasma polyunsaturated fatty acids and selected coronary disease risk factors in Tanzania. East Afr Med J 2005; 82 (11): 572-8
9. Marcelo CL, Dunham WR. Fatty acid metabolism studies of human epidermal cell cultures. J Lipid Res 1993; 34 (12): 2077-90
10. Gebauer SK, Psota TL, Harris WS, et al. n-3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. Am J Clin Nutr 2006; 83 (6 Suppl.): 1526S-35S
11. Engler MM, Engler MB. Omega-3 fatty acids: role in cardiovascular health and disease. J Cardiovasc Nurs 2006; 21 (1): 17-24
12. Gaddi A, Cicero AFG, Pedro E. Clinical perspectives of anti-inflammatory therapy in the elderly: the Lox-/Cox- inhibition concept. Arch Geriatr Gerontol 2004; 38 (3): 201-12
13. Francois H, Coffman TM. Prostanoids and blood pressure: which way is up? J Clin Invest 2004; 114 (6): 757-9
14. Wolf G. Free radical production and angiotensin. Curr Hypertens Res 2000; 2: 167-73
15. On YK, Kim CH, Oh BH, et al. Effects of angiotensin converting enzyme inhibitor and calcium antagonist on endothelial function in patients with essential hypertension. Hypertens Res 2002; 25: 365-71
16. Bhatnagar D, Durrington PN. Omega-3 fatty acids: their role in the prevention and treatment of atherosclerosis related risk factors and complications. Int J Clin Pract 2003; 57: 305-514
17. Kumar KV, Das UN. Effect of cis-unsaturated fatty acids, prostaglandins, and free radicals on angiotensin converting enzyme activity in vitro. Proc Exp Biol Med 1997; 214: 331-6
18. Mohan IK, Das UN. Effect of L-arginine-nitric oxide system on the metabolism of essential fatty acids in chemical induced diabetes mellitus in experimental animals by polyunsaturated fatty acids. Nutrition 2001; 17: 126-51
19. Taddei S, Virdis A, Ghiadoni L, et al. Restoration of nitric oxide availability after calcium antagonist treatment in essential hypertension. Hypertension 2001; 37: 943-8
20. Singhal A, Cole TJ, Lucas A. Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 2001; 357: 413-9
21. Jensen CL. Effects of n-3 fatty acids during pregnancy and lactation. Am J Clin Nutr 2006; 83 (6 Suppl.): 1452S-7S
22. Das UN. Long-chain polyunsaturated fatty acids interact with nitric oxide, superoxide anion, and transforming growth factor-beta to prevent human essential hypertension. Eur J Clin Nutr 2004; 58 (2): 195-203
23. Borghi C, Dormi A, Veronesi M, et al. Association between different lipid-lowering treatment strategies and blood pressure control in the Brisighella Heart Study. Am Heart J 2004; 148: 285-92
24. Arita M, Bianchini F, Aliberti J, et al. Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 2005; 201: 713-22
25. Bannenberg GL, Chiang N, Ariel A, et al. Molecular circuits of resolution: formation and actions of resolvins and protectins. J Immunol 2005; 174: 4345-55
26. Serhan CN, Arita M, Hong S, et al. Resolvins, docosatrienes, and neuroprotectins, novel omega-3-derived mediators, and their endogenous aspirin-triggered epimers. Lipids 2004; 39: 1125-32
27. Alexander Aguilera A, Hernandez Diaz G, Lara Barcelata M, et al. Induction of Cd36 expression elicited by fish oil PUFA in spontaneously hypertensive rats. J Nutr Biochem 2006; 17 (11): 760-5
28. Aguila MB, Pinheiro AR, Aquino JC, et al. Different edible oil beneficial effects (canola oil, fish oil, palm oil, olive oil, and soybean oil) on spontaneously hypertensive rat glomerular enlargement and glomeruli number. Prostaglandins Other Lipid Mediat 2005; 76 (1-4): 74-85
29. Deckelbaum RJ, Worgall TS, Seo T. n-3 fatty acids and gene expression. Am J Clin Nutr 2006; 83 (6 Suppl.): 1520S-5S
30. Goodfellow J, Bellamy MF, Ramsey MW, et al. Dietary supplementation with marine omega-3 fatty acids improve systemic large artery endothelial function in subjects with hypercholesterolemia. J Am Coll Cardiol 2000; 35: 267-70
31. Nestel P, Shige H, Pomeroy S, et al. The n-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid increase systemic arterial compliance in humans. Am J Clin Nutr 2002; 76 (2): 326-30
32. Tomiyama H, Takazawa K, Osa S, et al. Do eicosapentaenoic acid supplements attenuate age-related increases in arterial stiffness in patients with dyslipidemia? A preliminary study. Hypertens Res 2005; 28 (8): 651-5
33. Grimsgaard S, Bonaa KH, Hansen JB, et al. Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans. Am J Clin Nutr 1998; 68: 52-9
34. Engler MM, Engler MB, Pierson DM, et al. Effects of docosahexaenoic acid on vascular pathology an reactivity in hypertension. Exp Biol Med 2003; 228: 299-307
35. Bao DQ, Mori T, Burke V, et al. Effects of dietary fish and weight reduction on ambulatory blood pressure in overweight hypertensives. Hypertension 1998; 32: 710-7
36. Christensen JH, Skou HA, Madsen T, et al. Heart rate variability and n-3 polyunsaturated fatty acids in patients with diabetes mellitus. J Intern Med 2001; 249: 545-52
37. Mori TA, Bao DQ, Burke V, et al. Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension 1999; 34: 253-60
38. Geleijnse JM, Giltay EJ, Grobbee DE, et al. Blood pressure response to fish oil supplementation: metaregression analysis of randomized trials. J Hypertens 2002; 20: 1493-9
39. Sanders TA, Gleason K, Griffin B, et al. Influence of an algal triacylglycerol containing docosahexaenoic acid (22: 6n-3) and docosapentaenoic acid (22: 5n-6) on cardiovascular risk factors in healthy men and women. Br J Nutr 2006; 95 (3): 525-31
40. Rasmussen BM, Vessby B, Uusitupa M, et al. Effects of dietary saturated, monounsaturated, and n-3 fatty acids on blood pressure in healthy subjects. Am J Clin Nutr 2006; 83 (2): 221-6
41. Damsgaard CT, Schack-Nielsen L, Michaelsen KF, et al. Fish oil affects blood pressure and the plasma lipid profile in healthy Danish infants. J Nutr 2006; 136 (1): 94-9
42. Kris-Etherton PM, Harris WS, Appel LJ, et al. AHA scientific statement. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 2002; 106: 2747-57
43. Nettleton JA, Katz R. n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. J Am Diet Assoc 2005; 105 (3): 428-40
44. Hooper L, Thompson RL, Harrison RA, et al. Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review. BMJ 2006; 332: 752-60
45. Guallar E, Sanz-Gallardo MI, van't Veer P, et al. Mercury, fish oils, and the risk of myocardial infarction. Heavy Metals and Myocardial Infarction Study Group. N Engl J Med 2002; 347: 1747-54
46. Cohen JT, Bellinger DC, Connor WE, et al. A quantitative risk-benefit analysis of changes in population fish consumption. Am J Prev Med 2005; 29 (4): 325-34
47. Gaziano TA. Cardiovascular disease in the developing world and its cost-effective management. Circulation 2005; 112 (23): 3547-53
48. McInnes GT. Lowering blood pressure for cardiovascular risk reduction. J Hypertens Suppl 2005; 23 (1): S3-8
49. Cicero AFG, Gaddi AV, Borghi C. Complementary medicine for hypertension: what evidence for herbalist suggestions? Evaluation of risks and potential applications. Evid Based Integr Med 2005; 2 (1): 47-55
50. Wang C, Harris WS, Chung M, et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review. Am J Clin Nutr 2006; 84 (1): 5-17
51. Tavazzi L, Tognoni G, Franzosi MG, et al. GISSI-HF Investigators. Rationale and design of the GISSI heart failure trial: a large trial to assess the effects of n-3 polyunsaturated fatty acids and rosuvastatin in symptomatic congestive heart failure. Eur J Heart Fail 2004; 6 (5): 635-41
52. Mori TA. Omega-3 fatty acids and hypertension in humans. Clin Exp Pharmacol Physiol 2006; 33 (9): 842-6