Copper deficiency decreases plasma homocysteine in rats

Journal of Nutrition

Volumn 137, Issue 6, 2007, Pages 1370-1374

  Uthus, Eric O ^a   Reeves, Philip G ^a   Saari, Jack T ^a  

^a GRAND FORKS HUMAN NUTRITION RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETAINE HOMOCYSTEINE METHYLTRANSFERASE; COPPER; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; HOMOCYSTEINE; PROTEIN SUBUNIT;

AMINO ACID METABOLISM; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; COPPER DEFICIENCY; DOWN REGULATION; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; RAT; RECYCLING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION;

RATTUS;

EID: 34249819376     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.1093/jn/137.6.1370     Document Type: Article

References (33)

1. Saari JT, Schuschke DA. Cardiovascular effects of dietary copper deficiency. Biofactors. 1999;10:359-75.
2. Lear PM, Prohaska JR. Atria and ventricles of copper-deficient rats exhibit similar hypertrophy and similar altered biochemical characteristics. Proc Soc Exp Biol Med. 1997;215:377-85.
3. Refsum H, Ueland PM, Nygard O, Vollset SE. Homocysteine and cardiovascular disease. Annu Rev Med. 1998;49:31-62.
4. Brown JC, Strain JJ. Effect of dietary homocysteine on copper status in rats. J Nutr. 1990;120:1068-74.
5. Tamura T, Hong KH, Mizuno Y, Johnston KE, Keen CL. Folate and homocysteine metabolism in copper-deficient rats. Biochim Biophys Acta. 1999;1427:351-6.
6. Chen Y, Saari JT, Kang YJ. Expression of gamma-glutamylcysteine synthetase in the liver of copper-deficient rats. Proc Soc Exp Biol Med. 1995;210:102-6.
7. Reeves PG, Ralston NV, Idso JP, Lukaski HC. Contrasting and cooperative effects of copper and iron deficiencies in male rats fed different concentrations of manganese and different sources of sulfur amino acids in an AIN-93G-based diet. J Nutr. 2004;134:416-25.
8. Kato N, Saari JT, Schelkoph GM. Cystine feeding enhances defects of dietary copper deficiency by a mechanism not involving oxidative stress. J Nutr Biochem. 1994;5:99-105.
9. Nielsen FH. Sulfur amino acid nutriture affects the signs of copper deficiency in the rat. J Trace Elem Exp Med. 1988;1:157-66.
10. Johnson PE, Korynta ED. Effects of copper, iron, and ascorbic acid on manganese availability to rats. Proc Soc Exp Biol Med. 1992;199:470-80.
11. Davis CD, Feng Y. Dietary copper, manganese and iron affect the formation of aberrant crypts in colon of rats administered 3,2′-dimethyl-4- aminobiphenyl. J Nutr. 1999;129:1060-7.
12. Reeves PG, Nielsen FH, Fahey GC, Jr. AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J Nutr. 1993;123:1939-51.
13. National Research Council. Guide for the care and use of laboratory animals. Washington, DC: National Academies Press; 1996.
14. Davis CD, Uthus EO, Finley JW. Dietary selenium and arsenic affect DNA methylation in vitro in Caco-2 cells and in vivo in rat liver and colon. J Nutr. 2000;130:2903-9.
15. Wagner J, Claverie N, Danzin C. A rapid high-performance liquid chromatographic procedure for the simultaneous determination of methionine, ethionine, S-adenosylmethionine, S-adenosylethionine, and the natural polyamines in rat tissues. Anal Biochem. 1984;140:108-16.
16. Durand P, Fortin LJ, Lussier-Cacan S, Davignon J, Blache D. Hyperhomocysteinemia induced by folic acid deficiency and methionine load-applications of a modified HPLC method. Clin Chim Acta. 1996;252:83-93.
17. Heid CA, Stevens J, Livak KJ, Williams PM. Real time quantitative PCR. Genome Res. 1996;6:986-94.
18. Allen KG, Arthur JR, Morrice PC, Nicol F, Mills CF. Copper deficiency and tissue glutathione concentration in the rat. Proc Soc Exp Biol Med. 1988;187:38-43.
19. Finkelstein JD. Pathways and regulation of homocysteine metabolism in mammals. Semin Thromb Hemost. 2000;26:219-25.
20. Bethin KE, Petrovic N, Ettinger MJ. Identification of a major hepatic copper binding protein as S-adenosylhomocysteine hydrolase. J Biol Chem. 1995;270:20698-702.
21. Wagner C, Briggs WT, Cook RJ. Inhibition of glycine N-methyltransferase activity by folate derivatives: implications for regulation of methyl group metabolism. Biochem Biophys Res Commun. 1985;127:746-52.
22. Cook RJ, Wagner C. Glycine N-methyltransferase is a folate binding protein of rat liver cytosol. Proc Natl Acad Sci USA. 1984;81:3631-4.
23. Mosharov E, Cranford MR, Banerjee R. The quantitatively important relationship between homocysteine metabolism and glutathione synthesis by the transsulfuration pathway and its regulation by redox changes. Biochemistry. 2000;39:13005-11.
24. Maxwell SR. Coronary artery disease-free radical damage, antioxidant protection and the role of homocysteine. Basic Res Cardiol. 2000;95:Suppl 1:I65-71.
25. Dudman NPB. An alternate view of homocysteine. Lancet. 1999;354:2072-4.
26. Milne DB. Copper intake and assessment of copper status. Am J Clin Nutr. 1998;67:1041S-5S.
27. Finkelstein JD. Methionine metabolism in mammals. J Nutr Biochem. 1990;1:228-37.
28. Finkelstein JD, Martin JJ, Harris BJ. Methionine metabolism in mammals. The methionine-sparing effect of cystine. J Biol Chem. 1988;263:11750-4.
29. Finkelstein JD, Mudd SH. Transsulfuration in mammals. The methionine-sparing action of cysteine. J Biol Chem. 1967;242:873-80.
30. Fields M, Lewis CG, Lure MD. Copper deficiency in rats: the effect of type of dietary protein. J Am Coll Nutr. 1993;12:303-6.
31. Uthus EO, Yokoi K, Davis CD. Selenium deficiency in Fisher-344 rats decreases plasma and tissue homocysteine concentrations and alters plasma homocysteine and cysteine redox status. J Nutr. 2002;132:1122-8.
32. Uthus EO, Ross SA. Dietary selenium affects homocysteine metabolism differently in Fisher-344 rats and CD-1 mice. J Nutr. (in press).
33. Hill KE, Burk RF. Effect of selenium deficiency and vitamin E deficiency on glutathione metabolism in isolated rat hepatocytes. J Biol Chem. 1982;257:10668-72.