Consanguineous marriages and their effects on common adult diseases: Studies from an endogamous population

Medical Principles and Practice

Volumn 16, Issue 4, 2007, Pages 262-267

  Bener, Abdulbari ^a,b,e   Hussain, Rafat ^c   Teebi, Ahmad S ^d  

^a HAMAD GENERAL HOSPITAL   (Qatar)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

^c UNIVERSITY OF NEW ENGLAND   (Australia)

^d HOSPITAL FOR SICK CHILDREN   (Canada)

^e WEILL CORNELL MEDICAL COLLEGE   (Qatar)

Author keywords

Consanguinity, diseases; Epidemiology; Genetics; Population based study

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; CANCER; CONFIDENCE INTERVAL; CONSANGUINEOUS MARRIAGE; CONSANGUINITY; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GASTROINTESTINAL DISEASE; HEALTH SURVEY; HEARING IMPAIRMENT; HEART DISEASE; HUMAN; HYPERTENSION; INBREEDING; INTERVIEW; MAJOR CLINICAL STUDY; MENTAL DISEASE; QATAR; SPOUSE; STATISTICAL SIGNIFICANCE; URBAN AREA;

ADOLESCENT; ADULT; CONSANGUINITY; CROSS-SECTIONAL STUDIES; DISEASE; FEMALE; GENETIC DISEASES, INBORN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MARRIAGE; MIDDLE AGED; PREVALENCE; QATAR; SOCIOECONOMIC FACTORS;

EID: 34249812693     PISSN: 10117571     EISSN: None     Source Type: Journal    
DOI: 10.1159/000102147     Document Type: Article

References (32)

1. Al-Awaadi SA, Moussa MA, Naguib KK, Farag TI, Teebi AS, El-Khalifa M, El-Dossary L: Consanguinity among the Kuwait population. Clin Genet 1985;27:483-486.
2. Al-Ghazali, LI, Al-Wash R, Abdulrazzaq MY: United Arab Emirates: communities and community genetics. Community Genet 2005;8:186-196.
3. Bener A, Zirie M, Al-Rikabi R: Genetics, obesity and environmental risk factors associated with type 2 diabetes. Croat Med J 2005;46:302-307.
4. Jaber L, Shohat T, Rotter JI, Shohat M: Consanguinity and common adult diseases in Israeli Arab communities. Am J Med Genet 1997;70:346-348.
5. Bittles AH, Grant J, Sullivan SG, Hussain R: Does inbreeding lead to decreased human fertility? Ann Hum Biol 2002;29:111-130.
6. Bener A, Abdulrazzaq MY, Al-Gazali LI, Micallef R, Al-Khayat AI, Gaber T: Consanguinity and associated socio-demographic factors in the United Arab Emirates. Hum Hered 1996;46:256-264.
7. Mokhtar MM, Abdel-Fattah M: Major birth defects among infants with Down syndrome in Alexandria, Egypt (1995-2000): trends and risk factors. East Mediterr Health J 2001;7:441-451.
8. Khoury SA, Massad D: Consanguineous marriage in Jordan. Am J Med Genet 1992;43:769-775.
9. Sueyoshi S, Ohtsuka R: Effects of polygyny and consanguinity on high fertility in the rural Arab population in South Jordan. J Biosoc Sci 2003;35:513-526.
10. El-Hazmi MAF, Al-Swailem AR, Warsy AS, Al-Swailem AM, Sulaimani R, Al-Meshari AA: Consanguinity among Saudi Arabian population. J Med Genet 1995;32:623-626.
11. Bener A, Al-Ali K: Consanguineous marriage in a newly developed country: the Qatari population. J Biosoc Sci 2006;38:239-246.
12. Bener A, Hussain R: Consanguineous unions and child health in the State of Qatar. Paediatr Perinat Epidemiol 2006;20:372-378.
13. Jurdi R, Saxena PC: The prevalence and correlates of consanguineous marriages in Yemen: similarities and contrasts with other Arab countries. J Biosoc Sci 2003;35:1-13.
14. Gunaid AA, Hummad NA, Tamim KA: Consanguineous marriage in the capital city Sana'a, Yemen. J Biosoc Sci 2004;36:111-121.
15. Rajab A, Patton MA: A study of consanguinity in the Sultanate of Oman. Ann Hum Biol 2000;27:321-326.
16. Saadat M, Ansari-Lari M, Farhud DD: Consanguineous marriage in Iran. Ann Hum Biol 2004;31:263-269.
17. Charlesworth B, Hughes KA: The maintenance of genetic variation in life history traits; in Singh RS, Krimbas CB (eds): Evolutionary Genetics: From Molecules to Morphology. Cambridge, Cambridge University Press, 1999, vol 1.
18. Ben Arab S, Masmoudi S, Beltaief N, Hachicha S, Ayadi H: Consanguinity and endogamy in Northern Tunisia and its impact on non-syndromic deafness. Genet Epidemiol 2004;27:74-79.
19. Bittles AH: Consanguineous marriage and childhood health. Dev Med Child Neurol 2003;45:571-576.
20. Wright AF, Hastie ND: Complex genetic diseases: Controversy over the Croesus code. Genome Biol 2001;2:1-8.
21. Bener A, Denic S, Al-Mazrouei M: Consanguinity and family history of cancer in children with leukaemia and lymphomas. Cancer 2001;92:1-6.
22. Emery A: Methodology in medical genetics. An Introduction to Statistical Methods. Edinburgh, Churchill Livingstone, 1976, p 20.
23. Khlat M, Khoury M: Inbreeding and diseases: demographic, genetics and epidemiologic perspectives. Epidemiol Rev 1991;13:28-41.
24. Tamim H, Khogali M, Beydoun H, Melki I, Yunis K: National Collaborative Perinatal Neonatal Network: consanguinity and apnea of prematurity. Am J Epidemiol 2003;158:942-946.
25. Moynihan L, Houseman M, Newton V, Mueller R, Lench N: DFNB20: a novel locus for autosomal recessive, non-syndromal sensorineural hearing loss maps to chromosome 11q25-qter. Eur J Hum Genet 1999;7:243-246.
26. McHale DP, Jackson AP, Campbell DA, Levene MI, Corry P, Woods CG, Lench NJ, Mueller RF, Markham AF: A gene for ataxic cerebral palsy maps to chromosome 9p12-q12. Eur J Hum Genet 1999;8:267-272.
27. Roberts JAF, Pembrey ME: Cousin marriage; in Roberts JAF, Pembrey ME (eds): An Introduction to Medical Genetics. New York, Oxford University Press, 1978, p 295.
28. Devi ARR, Rao NA, Bittles AH: Inbreeding and the incidence of childhood genetic disorders in Karnataka, South India. J Med Genet 1987;24:362-365.
29. Al-Abdulkareem AA, Ballal SG: Consanguineous marriage in an urban area of Saudi Arabia: rates and adverse health effects on the offspring. J Community Health 1998;23:75-83.
30. Bittles AH, Mason WM, Greene J, Rao NA: Reproductive behaviour and health in consanguineous marriages. Science 1991;252:789-794.
31. Stoll C, Alembik Y, Roth MP, Dott B: Parental consanguinity as a cause for increased incidence of birth defects in a study of 238,942 consecutive births. Ann Genet 1999;42:133-139.
32. Abdulrazzaq YM, Bener A, Al-Gazali LI, Al-Khayat AI, Micallef R, Gaber T: A study of possible deleterious effects of consanguinity. Clin Genet 1997;51:167-173.