Elevated expression of NF-κB in oral submucous fibrosis - Evidence for NF-κB induction by safrole in human buccal mucosal fibroblasts

Oral Oncology

Volumn 43, Issue 6, 2007, Pages 557-562

  Ni, Wei Feng ^a   Tsai, Chung Hung ^b   Yang, Shun Fa ^a   Chang, Yu Chao ^a,b  

^a CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Buccal mucosal fibroblasts; Nuclear factor B; Oral submucous fibrosis; Safrole

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ACETYLCYSTEINE; CYCLOOXYGENASE 2 INHIBITOR; CYCLOSPORIN A; DEXAMETHASONE; GLUTATHIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; POLYPHENOL; SAFROLE;

ARTICLE; BETEL NUT; CELL CULTURE; CHEEK MUCOSA; CONTROLLED STUDY; CYTOTOXICITY; DOSE RESPONSE; ENDOTHELIUM CELL; FIBROBLAST; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATORY CELL; MOUTH DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; WESTERN BLOTTING;

BLOTTING, WESTERN; CELLS, CULTURED; CHEEK; FIBROBLASTS; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; MOUTH MUCOSA; NF-KAPPA B; ORAL SUBMUCOUS FIBROSIS; SAFROLE;

EID: 34249809381     PISSN: 13688375     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.oraloncology.2006.06.007     Document Type: Article

References (30)

1. Pindborg J.J. Oral submucous fibrosis: a review. Annals Acad Med, Singapore 18 (1989) 603-607
2. Sinor P.N., Gupta P.C., Murti P.R., Bhonsle R.B., Daftary D.K., Mehta F., et al. A case-control study of oral submucous fibrosis with special reference to the etiologic role of areca nut. J Oral Pathol Med 19 (1990) 94-98
3. Maber R., Lee A.J., Warnakulasuriya K.A.A.S., Lewis J.A., and Johnson N.W. Role of areca nut in the causation of oral submucous fibrosis: a case-control study in Pakistan. J Oral Pathol Med 23 (1994) 65-69
4. IARC. Betel-quid and areca-nut chewing. Lyon: International Agency for Research on Cancer, Monographs 1986; 37: 141-202.
5. Ko Y.C., Chiang T.A., Chang S.J., and Heish S.F. Prevalence of betel quid chewing habit in Taiwan and related sociodemographic factors. J Oral Pathol Med 21 (1992) 261-264
6. Reddy M.V., and Randerath K. A comparison of DNA adduct formation in white blood cells and internal organs of mice exposed to benzo[a]pyrene, dibenzo[c,g]carbazole, safrole and cigarette smoke condensate. Mutat Res 241 (1990) 37-48
7. Chen C.L., Chi C.W., Chang K.W., and Liu T.Y. Safrole-like DNA adducts in oral tissue from oral cancer patients with a betel quid chewing history. Carcinogenesis 20 (1999) 2331-2334
8. Shieh D.H., Chiang L.C., Lee C.H., Yang Y.H., and Shieh T.Y. Effects of arecoline, safrole, and nicotine on collagen phagocytosis by human buccal mucosal fibroblasts as a possible mechanism for oral submucous fibrosis in Taiwan. J Oral Pathol Med 22 (2004) 581-587
9. Shieh D.H., Chiang L.C., and Shieh T.Y. Augmented mRNA expression of tissue inhibitor of metalloproteinase-1 in buccal mucosal fibroblasts by arecoline and safrole as a possible pathogenesis for oral submucous fibrosis. Oral Oncol 39 (2003) 728-735
10. Ghosh S., May M.J., and Kopp E.B. NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Ann Rev Immunol 16 (1998) 225-260
11. Parsonnet J. Molecular mechanisms for inflammation-promoted carcinogenesis of cancer-The Sixteenth International Symposium of Sapporo Cancer Seminar. Cancer Res 57 (1997) 3620-3624
12. Hogaboam C.M., Steinhauser M.L., Chensue S.W., and Kunkel S.I. Novel roles for chemokines and fibroblasts in interstitial fibrosis. Kidney Int 54 (1998) 2152-2159
13. Lee M.J., Hsu J.D., Lin C.L., Lin M.H., Yuan S.C., and Wang C.J. Induction of epidermal proliferation and expressions of PKC and NF-κB by betel quid extracts in mouse: the role of lime-piper additives in betel quid. Chemico-Biol Interact 140 (2002) 35-48
14. Lin S.C., Lu S.Y., Lee S.Y., Lin C.Y., Chen C.H., and Chang K.W. Areca (betel) nut extract activates mitogen-activated protein kinases and NF-κB in oral keratinocytes. Int J Cancer 116 (2005) 526-535
15. Rameshwar P., Narayanan R., Qian J., Denny T.N., Colon C., and Gascon P. NF-κB as a central mediator in the induction of TGF-beta in monocytes from patients with idiopathic myelofibrosis: an inflammatory response beyond the realm of homeostasis. J Immunol 165 (2000) 2271-2277
16. Li J.J., and Gao R.L. Should atherosclerosis be considered a cancer of the vascular wall?. Med Hypotheses 64 (2005) 694-698
17. Chang Y.C., Tsai C.H., Tai K.W., Yang S.H., Chou M.Y., and Lii C.K. Elevated vimentin expression in buccal mucosal fibroblasts by arecoline in vitro as a possible pathogenesis for oral submucous fibrosis. Oral Oncol 38 (2002) 425-430
18. Chang Y.C., Tai K.W., Chou M.Y., and Tseng T.H. Synergistic effects of peroxynitrite on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts. Toxicol Lett 118 (2000) 61-68
19. Chang Y.C., Hu C.C., Tseng T.H., Tai K.W., Lii C.K., and Chou M.Y. Synergistic effects of nicotine on arecoline-induced cytotoxicity in human buccal mucosal fibroblasts. J Oral Pathol Med 30 (2001) 458-464
20. Pindorg J.J., Murti P.R., Bhonsle R.B., Gupta P.C., Daftary D.K., and Mehta F.S. Oral submucous fibrosis as a precancerous condition. Scand J Dental Res 92 (1984) 224-229
21. Bharti A., and Aggarwal B. Nuclear factor-kappa B and cancer: its role in prevention and therapy. Biochem Pharmacol 64 (2002) 883-888
22. De Vries N., and De Flora S. N-acetly-l-cysteine. J Cell Biochem 221 (1978) 713-717
23. Sundqvist H., Liu Y., Nair J., Bartsch H., Arvidson H., and Grafstrom R.C. Cytotoxic and genotoxic effect of areca nut-related compounds in cultured human buccal epithelial cells. Cancer Res 49 (1989) 5294-5298
24. Jeng J.H., Kuo M.L., Hahn L.J., and Kuo M.Y.P. Genotoxic and non-genotoxic effects of betel quid ingredients on oral mucosal fibroblasts in vitro. J Dental Res 75 (1994) 1043-1049
25. Wong D.Y.K., Hsiao Y.L., Poon C.K., Kwan P.C., Chao S.Y., Chou S.T., et al. Glutathione concentration in oral cancer tissues. Cancer Lett 81 (1994) 11-16
26. Johnson G.L., and Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science 298 (2002) 1911-1912
27. Zhao Q., and Lee F.S. J Biol Chem 274 (1999) 8355-8358
28. Chang M.C., Wu H.L., Lee J.J., Lee P.H., Chang H.H., Hahn L.J., et al. The induction of prostaglandin E2 production, interleukin-6 production, cell cycle arrest, and cytotoxicity in primary oral keratinocytes and KB cancer cells by areca nut ingredients is differentially regulated by MEK/ERK Activation. J Biol Chem 279 (2004) 50676-50683
29. Tsai C.H., Chou M.Y., and Chang Y.C. The upregulation of cyclooxygenase-2 expression in human buccal mucosal fibroblasts by arecoline: a possible role in the pathogenesis of oral submucous fibrosis. J Oral Pathol Med 32 (2003) 146-153
30. Tang D.W., Lin S.C., Chang K.W., Chi C.W., Chang C.S., and Liu T.Y. Elevated expression of cyclooxygenase (COX)-2 in oral sequamous cell carcinoma-evidence for COX-2 induction by areca quid ingredients in oral keratinocytes. J Oral Pathol Med 32 (2003) 522-529