Structural analysis of gubernaculum testis in cryptorchid patients submitted to treatment with human chorionic gonadotrophin

International Braz J Urol

Volumn 33, Issue 2, 2007, Pages 223-229

  El Zoghbi, Charbel S ^a   Favorito, Luciano A ^a   Costa, Waldemar S ^a   Sampaio, Francisco J B ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Connective tissue; Cryptorchidism; Human chorionic gonadotrophin; Muscle; Testis

Indexed keywords

EID: 34249791222     PISSN: 16775538     EISSN: 16776119     Source Type: Journal    
DOI: 10.1590/s1677-55382007000200014     Document Type: Article

References (22)

1. Gill B, Kogan S: Cryptorchidism. Current concepts. Pediatr Clin North Am. 1997; 44:1211-27.
2. Cendron M, Huff DS, Keating MA, Snyder HM 3rd, Duckett JW: Anatomical, morphological and volumetric analysis: a review of 759 cases of testicular maldescent. J Urol. 1993; 149: 570-3.
3. Heyns CF, Hutson JM: Historical review of theories on testicular descent. J Urol. 1995; 153: 754-67.
4. Favorito LA, Sampaio FJ, Javaroni V, Cardoso LE, Costa WS: Proximal insertion of gubernaculum testis in normal human fetuses and in boys with cryptorchidism. J Urol. 2000; 164:792-4.
5. Favorito LA, Klojda CA, Costa WS, Sampaio FJ: Is there a relationship with anomalous insertions of the distal gubernaculum testis and testicular ectopia? Analysis in human fetuses and patients with cryptorchidism. J Urol. 2003; 170: 554-7.
6. Backhouse KM: Embryology of testicular descent and maldescent. Urol Clin North Am. 1982; 9: 315-25.
7. Heyns CF: The gubernaculum during testicular descent in the human fetus. J Anat. 1987; 153: 93-112.
8. Costa WS, Sarnpaio FJ, Favorito LA, Cardoso LE: Testicular migration: remodeling of connective tissue and muscle cells in human gubernaculum testis. J Urol. 2002; 167:2171-6.
9. Beasley SW, Hutson JM: The role of the gubernaculum. in testicular descent. J Urol. 1988; 140: 1191-3.
10. Hosie S, Wessel L, Waag KL: Could testicular descent in humans be promoted by direct androgen stimulation of the gubernaculum testis? Eur J Pediatr Surg. 1999; 9: 37-41.
11. Vigueras RM, Reyes G, Moreno-Mendoza N, Merchant-Larios H: Gubernacular fibroblasts express the androgen receptor during testis descent in cryptorchid rats treated with human chorionic gonadotrophin. Urol Res. 2004; 32:386-90.
12. Elder JS, Isaacs JT, Walsh PC: Androgenic sensitivity of the gubernaculum testis: evidence for hormonal/mechanical interactions in testicular descent. J Urol. 1982; 127:170-6.
13. Weibel ER, Kistler GS, Scherle WF: Practical stereological methods for morphometric cytology. J Cell Biol. 1966; 30:23-38.
14. Sokol RR, Rohlf FJ: Biometry. Third edition. New York, Freeman WH. 1995.
15. Heyns CF, Human HJ, De Klerk DP: Hyperplasia and hypertrophy of the gubernaculum during testicular descent in the fetus. J Urol. 1986; 135: 1043-7.
16. Shono T, Suita S, Kai H, Yamaguchi Y: The effect of a prenatal androgen disruptor, vinclozolin, on gubernacular migration and testicular descent in rats. J Pediatr Surg. 2004; 39: 213-6.
17. Lackgren G, Ploen L: The influence of human chorionic gonadotrophin (hCG) on the morphology of the prepubertal human undescended testis. Int J Androl. 1984; 7: 39-52.
18. Kaleva M, Arsalo A, Louhimo I, Rapola J, Perheentupa J, Henriksen K, et al.: Treatment with human chorionic gonadotrophin for cryptorchidism: clinical and histological effects. Int J Androl. 1996; 19: 293-8.
19. Shenker NS, Huynh J, Farmer PJ, Hutson JM: A new role for androgen in testicular descent: permitting gubernacular cell proliferation in response to the neuropeptide, calcitonin gene-related peptide. J Pediatr Surg. 2006;41:407-12.
20. Tomiyama H, Hutson JM: Contractility of rat gubernacula affected by calcitonin gene-related peptide and beta-agonist. J Pediatr Surg. 2005; 40: 683-7.
21. Johansen TE, Blom GP: Histological studies of gubernaculum testis taken during orchiopexies. Scand J Urol Nephrol. 1988; 22: 107-8.
22. Soito I, Sampaio FJ, Cardoso LE: Collagen and glycosaminoglycan composition in gubernacula from human fetuses at different gestational ages, and from cryptorchid children. BJ_U Int. 2003; 91 Suppl 1: 76.