Acute Variceal Hemorrhage

Gastrointestinal Endoscopy Clinics of North America

Volumn 17, Issue 2, 2007, Pages 223-252

  Habib, Adil ^a,b   Sanyal, Arun J ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY MEDICAL CENTER   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ANTIBIOTIC AGENT; CEPHALOSPORIN; MONOETHANOLAMINE OLEATE; MORRHUATE SODIUM; NITRATE; OCTREOTIDE; POLIDOCANOL; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SOMATOSTATIN; TERLIPRESSIN; TETRADECYL SULFATE SODIUM; VAPREOTIDE; VASOPRESSIN;

ABDOMINAL CRAMP; ANTIBIOTIC PROPHYLAXIS; BACTERIAL PERITONITIS; BLOOD TRANSFUSION; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTINUOUS INFUSION; ENDOSCOPIC SCLEROTHERAPY; ESOPHAGUS VARICES BLEEDING; HEPATIC ENCEPHALOPATHY; HUMAN; HYPERGLYCEMIA; KIDNEY FAILURE; LIVER CIRRHOSIS; MULTIDETECTOR COMPUTED TOMOGRAPHY; PORTAL HYPERTENSION; PORTOSYSTEMIC ANASTOMOSIS; PRIORITY JOURNAL; RECURRENT DISEASE; REVIEW; SECONDARY PREVENTION; SIDE EFFECT; STOMACH SUCTION; STOMACH VARICES; ULCER; VASOCONSTRICTION;

ACUTE DISEASE; EMERGENCIES; ENDOSCOPY, GASTROINTESTINAL; ESOPHAGEAL AND GASTRIC VARICES; GASTROINTESTINAL HEMORRHAGE; HUMANS; HYPERTENSION, PORTAL; LIGATION; PORTASYSTEMIC SHUNT, TRANSJUGULAR INTRAHEPATIC; SCLEROTHERAPY;

EID: 34249787008     PISSN: 10525157     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.giec.2007.03.005     Document Type: Review

References (184)

1. de Franchis R. Updating consensus in portal hypertension: report of the Baveno III Consensus Workshop on definitions, methodology, and therapeutic strategies in portal hypertension. J Hepatol 33 5 (2000) 846-852
2. Cales P., Desmorat H., Vinel J.P., et al. Incidence of large oesophageal varices in patients with cirrhosis: application to prophylaxis of first bleeding. Gut 31 11 (1990) 1298-1302
3. Grace N.D. Prevention of initial variceal hemorrhage. Gastroenterol Clin North Am 21 1 (1992) 149-161
4. The North Italian Endoscopic Club for the Study and Treatment of Esophageal Varices. Prediction of the first variceal hemorrhage in patients with cirrhosis of the liver and esophageal varices. A prospective multicenter study. N Engl J Med 319 15 (1988) 983-989
5. Groszmann R.J., Garcia-Tsao G., Bosch J., et al. Beta blockers to prevent gastroesophageal varices in patients with cirrhosis. N Engl J Med 353 21 (2005) 2254-2261
6. Viallet A., Marleau D., Huet M., et al. Hemodynamic evaluation of patients with intrahepatic portal hypertension. Relationship between bleeding varices and the portohepatic gradient. Gastroenterology 69 6 (1975) 1297-1300
7. Garcia-Tsao G., Groszmann R.J., Fisher R.L., et al. Portal pressure, presence of gastroesophageal varices, and variceal bleeding. Hepatology 5 3 (1985) 419-424
8. Lebrec D., De Fleury P., Rueff B., et al. Portal hypertension, size of esophageal varices, and risk of gastrointestinal bleeding in alcoholic cirrhosis. Gastroenterology 79 6 (1980) 1139-1144
9. Prandi D., Rueff B., Roche-Sicot J., et al. Life-threatening hemorrhage of the digestive tract in cirrhotic patients. An assessment of the postoperative mortality after emergency portacaval shunt. Am J Surg 131 2 (1976) 204-209
10. Moitinho E., Escorsell A., Bandi J.C., et al. Prognostic value of early measurements of portal pressure in acute variceal bleeding. Gastroenterology 117 3 (1999) 626-631
11. Graham D.Y., and Smith J.L. The course of patients after variceal hemorrhage. Gastroenterology 80 4 (1981) 800-809
12. Smith J.L., and Graham D.Y. Variceal hemorrhage: a critical evaluation of survival analysis. Gastroenterology 82 5 Pt 1 (1982) 968-973
13. McCormick P.A., Jenkins S.A., McIntyre N., et al. Why portal hypertensive varices bleed and bleed: a hypothesis. Gut 36 1 (1995) 100-103
14. de Franchis R., and Primignani M. Why do varices bleed?. Gastroenterol Clin North Am 21 1 (1992) 85-101
15. Pagliaro L., D'Amico G., Luca A., et al. Portal hypertension: diagnosis and treatment. J Hepatol 23 Suppl 1 (1995) 36-44
16. Boyer T.D. Natural history of portal hypertension. Clin Liver Dis 1 1 (1997) 31-44, x
17. Sarin S.K., Lahoti D., Saxena S.P., et al. Prevalence, classification, and natural history of gastric varices: a long-term follow-up study in 568 portal hypertension patients. Hepatology 16 6 (1992) 1343-1349
18. Ready J.B., Robertson A.D., Goff J.S., et al. Assessment of the risk of bleeding from esophageal varices by continuous monitoring of portal pressure. Gastroenterology 100 5 Pt 1 (1991) 1403-1410
19. Burroughs A.K., Jenkins W.J., Sherlock S., et al. Controlled trial of propranolol for the prevention of recurrent variceal hemorrhage in patients with cirrhosis. N Engl J Med 309 25 (1983) 1539-1542
20. Burroughs A.K., and McCormick P.A. Prevention of variceal rebleeding. Gastroenterol Clin North Am 21 1 (1992) 119-147
21. de Dombal F.T., Clarke J.R., Clamp S.E., et al. Prognostic factors in upper GI bleeding. Endoscopy 18 Suppl 2 (1986) 6-10
22. de Franchis R. Developing consensus in portal hypertension. J Hepatol 25 3 (1996) 390-394
23. Kravetz D., Bosch J., Arderiu M., et al. Hemodynamic effects of blood volume restitution following a hemorrhage in rats with portal hypertension due to cirrhosis of the liver: influence of the extent of portal-systemic shunting. Hepatology 9 6 (1989) 808-814
24. Kravetz D., Sikuler E., and Groszmann R.J. Splanchnic and systemic hemodynamics in portal hypertensive rats during hemorrhage and blood volume restitution. Gastroenterology 90 5 Pt 1 (1986) 1232-1240
25. Grace N.D. Diagnosis and treatment of gastrointestinal bleeding secondary to portal hypertension. American College of Gastroenterology Practice Parameters Committee. Am J Gastroenterol 92 7 (1997) 1081-1091
26. Youssef W.I., Salazar F., Dasarathy S., et al. Role of fresh frozen plasma infusion in correction of coagulopathy of chronic liver disease: a dual phase study. Am J Gastroenterol 98 6 (2003) 1391-1394
27. Bosch J., Thabut D., Bendtsen F., et al. Recombinant factor VIIa for upper gastrointestinal bleeding in patients with cirrhosis: a randomized, double-blind trial. Gastroenterology 127 4 (2004) 1123-1130
28. Bleichner G., Boulanger R., Squara P., et al. Frequency of infections in cirrhotic patients presenting with acute gastrointestinal haemorrhage. Br J Surg 73 9 (1986) 724-726
29. Hsieh W.J., Lin H.C., Hwang S.J., et al. The effect of ciprofloxacin in the prevention of bacterial infection in patients with cirrhosis after upper gastrointestinal bleeding. Am J Gastroenterol 93 6 (1998) 962-966
30. Deitch E.A., Bridges W., Baker J., et al. Hemorrhagic shock-induced bacterial translocation is reduced by xanthine oxidase inhibition or inactivation. Surgery 104 2 (1988) 191-198
31. Baker J.W., Deitch E.A., Li M., et al. Hemorrhagic shock induces bacterial translocation from the gut. J Trauma 28 7 (1988) 896-906
32. Rimola A., Bory F., Teres J., et al. Oral, nonabsorbable antibiotics prevent infection in cirrhotics with gastrointestinal hemorrhage. Hepatology 5 3 (1985) 463-467
33. Bernard B., Grange J.D., Khac E.N., et al. Antibiotic prophylaxis for the prevention of bacterial infections in cirrhotic patients with gastrointestinal bleeding: a meta-analysis. Hepatology 29 6 (1999) 1655-1661
34. Bernard B., Cadranel J.F., Valla D., et al. Prognostic significance of bacterial infection in bleeding cirrhotic patients: a prospective study. Gastroenterology 108 6 (1995) 1828-1834
35. Goulis J., Armonis A., Patch D., et al. Bacterial infection is independently associated with failure to control bleeding in cirrhotic patients with gastrointestinal hemorrhage. Hepatology 27 5 (1998) 1207-1212
36. Hou M.C., Lin H.C., Liu T.T., et al. Antibiotic prophylaxis after endoscopic therapy prevents rebleeding in acute variceal hemorrhage: a randomized trial. Hepatology 39 3 (2004) 746-753
37. Cardenas A., Gines P., Uriz J., et al. Renal failure after upper gastrointestinal bleeding in cirrhosis: incidence, clinical course, predictive factors, and short-term prognosis. Hepatology 34 4 Pt 1 (2001) 671-676
38. Kremers W.K., van IJperen M., Kim W.R., et al. MELD score as a predictor of pretransplant and post-transplant survival in OPTN/UNOS status 1 patients. Hepatology 39 3 (2004) 764-769
39. Schmid P.G., Sharabi F.M., Guo G.B., et al. Vasopressin and oxytocin in the neural control of the circulation. Fed Proc 43 1 (1984) 97-102
40. Reichen J. Liver function and pharmacological considerations in pathogenesis and treatment of portal hypertension. Hepatology 11 6 (1990) 1066-1078
41. Bosch J., Mastai R., Kravetz D., et al. Measurement of azygos venous blood flow in the evaluation of portal hypertension in patients with cirrhosis. Clinical and haemodynamic correlations in 100 patients. J Hepatol 1 2 (1985) 125-139
42. Bosch J., Bordas J.M., Mastai R., et al. Effects of vasopressin on the intravariceal pressure in patients with cirrhosis: comparison with the effects on portal pressure. Hepatology 8 4 (1988) 861-865
43. Rodriguez-Perez F., and Groszmann R.J. Pharmacologic treatment of portal hypertension. Gastroenterol Clin North Am 21 1 (1992) 15-40
44. Kravetz D., Bosch J., Teres J., et al. Comparison of intravenous somatostatin and vasopressin infusions in treatment of acute variceal hemorrhage. Hepatology 4 3 (1984) 442-446
45. Conn H.O., Ramsby G.R., Storer E.H., et al. Intra-arterial vasopressin in the treatment of upper gastrointestinal hemorrhage: a prospective, controlled clinical trial. Gastroenterology 68 2 (1975) 211-221
46. Tsai Y.T., Lay C.S., Lai K.H., et al. Controlled trial of vasopressin plus nitroglycerin vs. vasopressin alone in the treatment of bleeding esophageal varices. Hepatology 6 3 (1986) 406-409
47. Gimson A.E., Westaby D., Hegarty J., et al. A randomized trial of vasopressin and vasopressin plus nitroglycerin in the control of acute variceal hemorrhage. Hepatology 6 3 (1986) 410-413
48. Bosch J., Groszmann R.J., Garcia-Pagan J.C., et al. Association of transdermal nitroglycerin to vasopressin infusion in the treatment of variceal hemorrhage: a placebo-controlled clinical trial. Hepatology 10 6 (1989) 962-968
49. Burroughs A.K., and Panagou E. Pharmacological therapy for portal hypertension: rationale and results. Semin Gastrointest Dis 6 3 (1995) 148-164
50. Drug therapy for portal hypertension: A five year review. In: de Franchis R. (Ed). Portal hypertension II: proceedings of IInd Baveno consensus workshop on definitions, methodology, and therapeutic strategies (1996), Oxford Blackwell Science
51. Blei A.T. Vasopressin analogs in portal hypertension: different molecules but similar questions. Hepatology 6 1 (1986) 146-147
52. Bloom S.R., and Polak J.M. Somatostatin. Br Med J (Clin Res Ed) 295 6593 (1987) 288-290
53. Brazeau P., Vale W., Burgus R., et al. Hypothalamic polypeptide that inhibits the secretion of immunoreactive pituitary growth hormone. Science 179 68 (1973) 77-79
54. Reichlin S. Somatostatin. N Engl J Med 309 24 (1983) 1495-1501
55. Reichlin S. Somatostatin (second of two parts). N Engl J Med 309 25 (1983) 1556-1563
56. Baxter J.N., and Jenkins S.A. Somatostatin: an alternative to sclerotherapy?. Scand J Gastroenterol Suppl 207 (1994) 17-22
57. Merkel C., Gatta A., Zuin R., et al. Effect of somatostatin on splanchnic hemodynamics in patients with liver cirrhosis and portal hypertension. Digestion 32 2 (1985) 92-98
58. Consolo F., and Pustorino S. Theoretical and physiopharmacological bases of the somatostatin treatment in digestive diseases [Italian]. Minerva Chir 47 8 (1992) 723-729
59. Hanisch E., Doertenbach J., and Usadel K.H. Somatostatin in acute bleeding oesophageal varices. Pharmacology and rationale for use. Drugs 44 Suppl 2 (1992) 24-35
60. Sieber C.C., and Stalder G.A. Pathophysiological and pharmacotherapeutic aspects of portal hypertension [German]. Schweiz Med Wochenschr 123 1-2 (1993) 3-13
61. Sonnenberg G.E., Keller U., Perruchoud A., et al. Effect of somatostatin on splanchnic hemodynamics in patients with cirrhosis of the liver and in normal subjects. Gastroenterology 80 3 (1981) 526-532
62. Tyden G., Samnegard H., Thulin L., et al. Circulatory effects of somatostatin in anesthetized man. Acta Chir Scand 145 7 (1979) 443-446
63. Bosch J., Kravetz D., and Rodes J. Effects of somatostatin on hepatic and systemic hemodynamics in patients with cirrhosis of the liver: comparison with vasopressin. Gastroenterology 80 3 (1981) 518-525
64. Eriksson L.S., Law D.H., Sato Y., et al. Influence of somatostatin on splanchnic haemodynamics in patients with liver cirrhosis. Clin Physiol 4 1 (1984) 5-11
65. Cirera I., Feu F., Luca A., et al. Effects of bolus injections and continuous infusions of somatostatin and placebo in patients with cirrhosis: a double-blind hemodynamic investigation. Hepatology 22 1 (1995) 106-111
66. McKee R. A study of octreotide in oesophageal varices. Digestion 45 Suppl 1 (1990) 60-64
67. Jenkins S.A., Baxter J.N., Corbett W.A., et al. Effects of a somatostatin analogue SMS 201-995 on hepatic haemodynamics in the pig and on intravariceal pressure in man. Br J Surg 72 12 (1985) 1009-1012
68. Mountokalakis T., Kallivretakis N., Mayopoulou-Symvoulidou D., et al. Enhancement of renal function by a long-acting somatostatin analogue in patients with decompensated cirrhosis. Nephrol Dial Transplant 3 5 (1988) 604-607
69. Gines A., Salmeron J.M., Gines P., et al. Effects of somatostatin on renal function in cirrhosis. Gastroenterology 103 6 (1992) 1868-1874
70. Bhargava D.K., Singh B., Dogra R., et al. Prospective randomized comparison of sodium tetradecyl sulfate and polidocanol as variceal sclerosing agents. Am J Gastroenterol 87 2 (1992) 182-186
71. Kitano S., Iso Y., Koyanagi N., et al. Ethanolamine oleate is superior to polidocanol (aethoxysklerol) for endoscopic injection sclerotherapy of esophageal varices: a prospective randomized trial. Hepatogastroenterology 34 1 (1987) 19-23
72. Binmoeller K.F., and Soehendra N. Superglue: the answer to variceal bleeding and fundal varices?. Endoscopy 27 5 (1995) 392-396
73. Kitano S., Koyanagi N., Iso Y., et al. Prevention of recurrence of esophageal varices after endoscopic injection sclerotherapy with ethanolamine oleate. Hepatology 7 5 (1987) 810-815
74. Sarin S.K., Nanda R., Sachdev G., et al. Intravariceal versus paravariceal sclerotherapy: a prospective, controlled, randomised trial. Gut 28 6 (1987) 657-662
75. Westaby D., Melia W.M., MacDougall B.R., et al. Injection sclerotherapy for oesophageal varices: a prospective randomised trial of different treatment schedules. Gut 25 2 (1984) 129-132
76. Sarin S.K., Sachdev G., Nanda R., et al. Comparison of the two time schedules for endoscopic sclerotherapy: a prospective randomised controlled study. Gut 27 6 (1986) 710-713
77. De la P.J., Rivero M., Sanchez E., et al. Variceal ligation compared with endoscopic sclerotherapy for variceal hemorrhage: prospective randomized trial. Gastrointest Endosc 49 4 Pt 1 (1999) 417-423
78. Waked I., and Korula J. Analysis of long-term endoscopic surveillance during follow-up after variceal sclerotherapy from a 13-year experience. Am J Med 102 2 (1997) 192-199
79. Westaby D., and Williams R. Follow-up study after sclerotherapy. Scand J Gastroenterol 102 Suppl (1984) 71-75
80. Westaby D., MacDougall B.R., and Williams R. Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. Hepatology 5 5 (1985) 827-830
81. Kahn D., Jones B., Bornman P.C., et al. Incidence and management of complications after injection sclerotherapy: a ten-year prospective evaluation. Surgery 105 2 Pt 1 (1989) 160-165
82. Sanowski R.A., and Waring J.P. Endoscopic techniques and complications in variceal sclerotherapy. J Clin Gastroenterol 9 5 (1987) 504-513
83. Schuman B.M., Beckman J.W., Tedesco F.J., et al. Complications of endoscopic injection sclerotherapy: a review. Am J Gastroenterol 82 9 (1987) 823-830
84. Sarin S.K. Endoscopic sclerotherapy for esophago-gastric varices: a critical reappraisal. Aust N Z J Med 19 2 (1989) 162-171
85. D'Amico G., Pagliaro L., and Bosch J. The treatment of portal hypertension: a meta-analytic review. Hepatology 22 1 (1995) 332-354
86. Gimson A., Polson R., Westaby D., et al. Omeprazole in the management of intractable esophageal ulceration following injection sclerotherapy. Gastroenterology 99 6 (1990) 1829-1831
87. Sarin S.K., Shahi H.M., Jain M., et al. The natural history of portal hypertensive gastropathy: influence of variceal eradication. Am J Gastroenterol 95 10 (2000) 2888-2893
88. Toyonaga A., and Iwao T. Portal-hypertensive gastropathy. J Gastroenterol Hepatol 13 9 (1998) 865-877
89. Sanyal A.J., Freedman A.M., Luketic V.A., et al. Transjugular intrahepatic portosystemic shunts for patients with active variceal hemorrhage unresponsive to sclerotherapy. Gastroenterology 111 1 (1996) 138-146
90. Stiegmann G.V., Sun J.H., and Hammond W.S. Results of experimental endoscopic esophageal varix ligation. Am Surg 54 2 (1988) 105-108
91. Stiegmann G.V., Goff J.S., Sun J.H., et al. Endoscopic variceal ligation: an alternative to sclerotherapy. Gastrointest Endosc 35 5 (1989) 431-434
92. Saeed Z.A. The Saeed Six-Shooter: a prospective study of a new endoscopic multiple rubber-band ligator for the treatment of varices. Endoscopy 28 7 (1996) 559-564
93. Shim C.S., Cho J.Y., Park Y.J., et al. Mini-detachable snare ligation for the treatment of esophageal varices. Gastrointest Endosc 50 5 (1999) 673-676
94. Sarin S.K., Govil A., Jain A.K., et al. Prospective randomized trial of endoscopic sclerotherapy versus variceal band ligation for esophageal varices: influence on gastropathy, gastric varices, and variceal recurrence. J Hepatol 26 4 (1997) 826-832
95. Hou M.C., Lin H.C., Kuo B.I., et al. Comparison of endoscopic variceal injection sclerotherapy and ligation for the treatment of esophageal variceal hemorrhage: a prospective randomized trial. Hepatology 21 6 (1995) 1517-1522
96. Laine L., el Newihi H.M., Migikovsky B., et al. Endoscopic ligation compared with sclerotherapy for the treatment of bleeding esophageal varices. Ann Intern Med 119 1 (1993) 1-7
97. Lo G.H., Lai K.H., Chang C.F., et al. Endoscopic injection sclerotherapy vs. endoscopic variceal ligation in arresting acute variceal bleeding for patients with advanced hepatocellular carcinoma. J Hepatol 21 6 (1994) 1048-1052
98. Laine L., and Cook D. Endoscopic ligation compared with sclerotherapy for treatment of esophageal variceal bleeding. A meta-analysis. Ann Intern Med 123 4 (1995) 280-287
99. Young M.F., Sanowski R.A., and Rasche R. Comparison and characterization of ulcerations induced by endoscopic ligation of esophageal varices versus endoscopic sclerotherapy. Gastrointest Endosc 39 2 (1993) 119-122
100. Banares R., Albillos A., Rincon D., et al. Endoscopic treatment versus endoscopic plus pharmacologic treatment for acute variceal bleeding: a meta-analysis. Hepatology 35 3 (2002) 609-615
101. Fleischer D. Etiology and prevalence of severe persistent upper gastrointestinal bleeding. Gastroenterology 84 3 (1983) 538-543
102. Cales P., Lacave N., Silvain C., et al. Prospective study on the application of the Baveno II Consensus Conference criteria in patients with cirrhosis and gastrointestinal bleeding. J Hepatol 33 5 (2000) 738-741
103. D'Amico G., and de Franchis R. Upper digestive bleeding in cirrhosis. Post-therapeutic outcome and prognostic indicators. Hepatology 38 3 (2003) 599-612
104. Lo G.H., Lai K.H., Cheng J.S., et al. Emergency banding ligation versus sclerotherapy for the control of active bleeding from esophageal varices. Hepatology 25 5 (1997) 1101-1104
105. Besson I., Ingrand P., Person B., et al. Sclerotherapy with or without octreotide for acute variceal bleeding. N Engl J Med 333 9 (1995) 555-560
106. Sanders D.S., Carter M.J., Goodchap R.J., et al. Prospective validation of the Rockall risk scoring system for upper GI hemorrhage in subgroups of patients with varices and peptic ulcers. Am J Gastroenterol 97 3 (2002) 630-635
107. Hussain H., Lapin S., and Cappell M.S. Clinical scoring systems for determining the prognosis of gastrointestinal bleeding. Gastroenterol Clin North Am 29 2 (2000) 445-464
108. Lee H., Hawker F.H., Selby W., et al. Intensive care treatment of patients with bleeding esophageal varices: results, predictors of mortality, and predictors of the adult respiratory distress syndrome. Crit Care Med 20 11 (1992) 1555-1563
109. Ben Ari Z., Cardin F., McCormick A.P., et al. A predictive model for failure to control bleeding during acute variceal haemorrhage. J Hepatol 31 3 (1999) 443-450
110. Zhao C., Chen S.B., Zhou J.P., et al. Prognosis of hepatic cirrhosis patients with esophageal or gastric variceal hemorrhage: multivariate analysis. Hepatobiliary Pancreat Dis Int 1 3 (2002) 416-419
111. Pohl J., Pollmann K., Sauer P., et al. Antibiotic prophylaxis after variceal hemorrhage reduces incidence of early rebleeding. Hepatogastroenterology 51 56 (2004) 541-546
112. Patch D., Armonis A., Sabin C., et al. Single portal pressure measurement predicts survival in cirrhotic patients with recent bleeding. Gut 44 2 (1999) 264-269
113. Grace N.D., Groszmann R.J., Garcia-Tsao G., et al. Portal hypertension and variceal bleeding: an AASLD single-topic symposium. Hepatology 28 3 (1998) 868-880
114. Hou M.C., Lin H.C., Kuo B.I., et al. The rebleeding course and long-term outcome of esophageal variceal hemorrhage after ligation: comparison with sclerotherapy. Scand J Gastroenterol 34 11 (1999) 1071-1076
115. Hou M.C., Lin H.C., Kuo B.I., et al. Sequential variceal pressure measurement by endoscopic needle puncture during maintenance sclerotherapy: the correlation between variceal pressure and variceal rebleeding. J Hepatol 29 5 (1998) 772-778
116. Hou M.C., Lin H.C., Lee F.Y., et al. Recurrence of esophageal varices following endoscopic treatment and its impact on rebleeding: comparison of sclerotherapy and ligation. J Hepatol 32 2 (2000) 202-208
117. Leung V.K., Sung J.J., Ahuja A.T., et al. Large paraesophageal varices on endosonography predict recurrence of esophageal varices and rebleeding. Gastroenterology 112 6 (1997) 1811-1816
118. Lo G.H., Lai K.H., Cheng J.S., et al. Prevalence of paraesophageal varices and gastric varices in patients achieving variceal obliteration by banding ligation and by injection sclerotherapy. Gastrointest Endosc 49 4 Pt 1 (1999) 428-436
119. Desmaizieres F.C., and Bobbio A. The world's first: laparoscopic portacaval H-graft shunt [French]. J Chir (Paris) 136 6 (1999) 333-340
120. de Franchis R., and Primignani M. Natural history of portal hypertension in patients with cirrhosis. Clin Liver Dis 5 3 (2001) 645-663
121. de Franchis R., Dellera A., Fazzini L., et al. Evaluation and follow-up of patients with portal hypertension and oesophageal varices: how and when. Dig Liver Dis 33 8 (2001) 643-646
122. Cipolletta L., Bianco M.A., Rotondano G., et al. Argon plasma coagulation prevents variceal recurrence after band ligation of esophageal varices: preliminary results of a prospective randomized trial. Gastrointest Endosc 56 4 (2002) 467-471
123. Lo G.H., Lai K.H., Cheng J.S., et al. The effects of endoscopic variceal ligation and propranolol on portal hypertensive gastropathy: a prospective, controlled trial. Gastrointest Endosc 53 6 (2001) 579-584
124. Pereira-Lima J.C., Zanette M., Lopes C.V., et al. The influence of endoscopic variceal ligation on the portal pressure gradient in cirrhotics. Hepatogastroenterology 50 49 (2003) 102-106
125. Sarin S.K., Jain A.K., Lamba G.S., et al. Isolated gastric varices: prevalence, clinical relevance, and natural history. Dig Surg 20 1 (2003) 42-47
126. Vargas H.E., and Rakela J. Liver transplantation for variceal hemorrhage. Gastrointest Endosc Clin N Am 9 2 (1999) 347-353
127. Cook D., and Laine L. Indications, technique, and complications of balloon tamponade for variceal gastrointestinal bleeding. J Intensive Care Med 7 4 (1992) 212-218
128. Hunt P.S., Korman M.G., Hansky J., et al. An 8-year prospective experience with balloon tamponade in emergency control of bleeding esophageal varices. Dig Dis Sci 27 5 (1982) 413-416
129. Teres J. Balloon tamponade vs. endoscopic sclerotherapy: in the management of active variceal hemorrhage. Hepatology 11 5 (1990) 898-899
130. Moreto M., Zaballa M., Bernal A., et al. A randomized trial of tamponade or sclerotherapy as immediate treatment for bleeding esophageal varices. Surg Gynecol Obstet 167 4 (1988) 331-334
131. Jaramillo J.L., de la M.M., Mino G., et al. Somatostatin versus Sengstaken balloon tamponade for primary haemostasia of bleeding esophageal varices. A randomized pilot study. J Hepatol 12 1 (1991) 100-105
132. Sanyal A.J. The use and misuse of transjugular intrahepatic portasystemic shunts. Curr Gastroenterol Rep 2 1 (2000) 61-71
133. Banares R., Casado M., Rodriguez-Laiz J.M., et al. Urgent transjugular intrahepatic portosystemic shunt for control of acute variceal bleeding. Am J Gastroenterol 93 1 (1998) 75-79
134. Chau T.N., Patch D., Chan Y.W., et al. Salvage transjugular intrahepatic portosystemic shunts: gastric fundal compared with esophageal variceal bleeding. Gastroenterology 114 5 (1998) 981-987
135. LaBerge J.M., Ring E.J., Gordon R.L., et al. Creation of transjugular intrahepatic portosystemic shunts with the wallstent endoprosthesis: results in 100 patients. Radiology 187 2 (1993) 413-420
136. Le Moine O., Deviere J., Ghysels M., et al. Transjugular intrahepatic portosystemic stent shunt as a rescue treatment after sclerotherapy failure in variceal bleeding. Scand J Gastroenterol Suppl 207 (1994) 23-28
137. Gerbes A.L., Gulberg V., Waggershauser T., et al. Transjugular intrahepatic portosystemic shunt (TIPS) for variceal bleeding in portal hypertension: comparison of emergency and elective interventions. Dig Dis Sci 43 11 (1998) 2463-2469
138. McCormick P.A., Dick R., Panagou E.B., et al. Emergency transjugular intrahepatic portasystemic stent shunting as salvage treatment for uncontrolled variceal bleeding. Br J Surg 81 9 (1994) 1324-1327
139. Sanyal AJ, Freedman AM, Shiffman ML, et al. Transjugular Intrahepatic Portosystemic Shunt (TIPS) for uncontrolled variceal hemorrhage in advanced cirrhotics at high-risk for surgery-a prospective-study. Gastroenterology 1993;104:A985 [Ref Type: Generic].
140. Haag K.R.M.H.K. Dertransjugulare intrahepatische stent-shunt (TIPS) in der Notfallbehandlung der portalen hypertension. Intensivemedizin 30 (1993) 479-483 [Ref Type: Generic]
141. Jalan R., John T.G., Redhead D.N., et al. A comparative study of emergency transjugular intrahepatic portosystemic stent-shunt and esophageal transection in the management of uncontrolled variceal hemorrhage. Am J Gastroenterol 90 11 (1995) 1932-1937
142. Sanyal A.J., Freedman A.M., Purdum P.P., et al. The hematologic consequences of transjugular intrahepatic portosystemic shunts. Hepatology 23 1 (1996) 32-39
143. Freedman A.M., Sanyal A.J., Tisnado J., et al. Complications of transjugular intrahepatic portosystemic shunt: a comprehensive review. Radiographics 13 6 (1993) 1185-1210
144. Sanyal A.J., and Reddy K.R. Vegetative infection of transjugular intrahepatic portosystemic shunts. Gastroenterology 115 1 (1998) 110-115
145. Malinchoc M., Kamath P.S., Gordon F.D., et al. A model to predict poor survival in patients undergoing transjugular intrahepatic portosystemic shunts. Hepatology 31 4 (2000) 864-871
146. Deschenes M., Dufresne M.P., Bui B., et al. Predictors of clinical response to transjugular intrahepatic portosystemic shunt (TIPS) in cirrhotic patients with refractory ascites. Am J Gastroenterol 94 5 (1999) 1361-1365
147. Williams D., Waugh R., Gallagher N., et al. Mortality and rebleeding following transjugular intrahepatic portosystemic stent shunt for variceal haemorrhage. J Gastroenterol Hepatol 13 2 (1998) 163-169
148. Henderson J.M. Salvage therapies for refractory variceal hemorrhage. Clin Liver Dis 5 3 (2001) 709-725
149. Cello J.P., Grendell J.H., Crass R.A., et al. Endoscopic sclerotherapy versus portacaval shunt in patients with severe cirrhosis and variceal hemorrhage. N Engl J Med 311 25 (1984) 1589-1594
150. Cello J.P., Grendell J.H., Crass R.A., et al. Endoscopic sclerotherapy versus portacaval shunt in patients with severe cirrhosis and acute variceal hemorrhage. Long-term follow-up. N Engl J Med 316 1 (1987) 11-15
151. Henderson J.M., Boyer T.D., Kutner M.H., et al. Distal splenorenal shunt versus transjugular intrahepatic portal systematic shunt for variceal bleeding: a randomized trial. Gastroenterology 130 6 (2006) 1643-1651
152. Ryan B.M., Stockbrugger R.W., and Ryan J.M. A pathophysiologic, gastroenterologic, and radiologic approach to the management of gastric varices. Gastroenterology 126 4 (2004) 1175-1189
153. Kim T., Shijo H., Kokawa H., et al. Risk factors for hemorrhage from gastric fundal varices. Hepatology 25 2 (1997) 307-312
154. Sarin S. Diagnostic issues: portal hypertensive gastropathy and gastric varices. In: DeFranchis R. (Ed). Portal Hypertension II: proceedings of the Second Baveno International Consensus Workshop on Definitions, Methodology and Therapeutic Strategies (1996), Blackwell Science, Oxford (UK) p. 30-55 [Ref Type: Generic]
155. Trudeau W., and Prindiville T. Endoscopic injection sclerosis in bleeding gastric varices. Gastrointest Endosc 32 4 (1986) 264-268
156. Korula J., Chin K., Ko Y., et al. Demonstration of two distinct subsets of gastric varices. Observations during a seven-year study of endoscopic sclerotherapy. Dig Dis Sci 36 3 (1991) 303-309
157. Hashizume M., Kitano S., Sugimachi K., et al. Three-dimensional view of the vascular structure of the lower esophagus in clinical portal hypertension. Hepatology 8 6 (1988) 1482-1487
158. Kage M., Korula J., Harada A., et al. Effects of sodium tetradecyl sulfate endoscopic variceal sclerotherapy on the esophagus. A prospective clinical and histopathologic study. J Clin Gastroenterol 9 6 (1987) 635-643
159. Sarin S.K., Sachdev G., and Nanda R. Follow-up of patients after variceal eradication. A comparison of patients with cirrhosis, noncirrhotic portal fibrosis, and extrahepatic obstruction. Ann Surg 204 1 (1986) 78-82
160. Korula J., and Ralls P. The effects of chronic endoscopic variceal sclerotherapy on portal pressure in cirrhotics. Gastroenterology 101 3 (1991) 800-805
161. Hashizume M., Kitano S., Yamaga H., et al. Endoscopic classification of gastric varices. Gastrointest Endosc 36 3 (1990) 276-280
162. Hosking S.W., and Johnson A.G. Gastric varices: a proposed classification leading to management. Br J Surg 75 3 (1988) 195-196
163. Schubert T.T., Schnell G.A., and Walden J.M. Bleeding from varices in the gastric fundus complicating sclerotherapy. Gastrointest Endosc 35 3 (1989) 268-269
164. Caletti G.C., Brocchi E., Ferrari A., et al. Value of endoscopic ultrasonography in the management of portal hypertension. Endoscopy 24 Suppl 1 (1992) 342-346
165. Willmann J.K., Weishaupt D., Bohm T., et al. Detection of submucosal gastric fundal varices with multidetector row CT angiography. Gut 52 6 (2003) 886-892
166. Bretagne J.F., Dudicourt J.C., Thevenet P., et al. Course of patients after eradication of esophageal varices by sclerotherapy: influence of the site of the first hemorrhage [French]. Gastroenterol Clin Biol 11 4 (1987) 341-342
167. Chang K.Y., Wu C.S., and Chen P.C. Prospective, randomized trial of hypertonic glucose water and sodium tetradecyl sulfate for gastric variceal bleeding in patients with advanced liver cirrhosis. Endoscopy 28 6 (1996) 481-486
168. Chiu K.W., Changchien C.S., Chuah S.K., et al. Endoscopic injection sclerotherapy with 1.5% Sotradecol for bleeding cardiac varices. J Clin Gastroenterol 24 3 (1997) 161-164
169. Gimson A.E., Westaby D., and Williams R. Endoscopic sclerotherapy in the management of gastric variceal haemorrhage. J Hepatol 13 3 (1991) 274-278
170. Ogawa K., Ishikawa S., Naritaka Y., et al. Clinical evaluation of endoscopic injection sclerotherapy using n-butyl-2-cyanoacrylate for gastric variceal bleeding. J Gastroenterol Hepatol 14 3 (1999) 245-250
171. Oho K., Iwao T., Sumino M., et al. Ethanolamine oleate versus butyl cyanoacrylate for bleeding gastric varices: a nonrandomized study. Endoscopy 27 5 (1995) 349-354
172. Sarin S.K. Long-term follow-up of gastric variceal sclerotherapy: an eleven-year experience. Gastrointest Endosc 46 1 (1997) 8-14
173. Shiha G., and El Sayed S.S. Gastric variceal ligation: a new technique. Gastrointest Endosc 49 4 Pt 1 (1999) 437-441
174. Takeuchi M., Nakai Y., Syu A., et al. Endoscopic ligation of gastric varices. Lancet 348 9033 (1996) 1038
175. Vitte R.L., Eugene C., Fingerhut A., et al. Fatal outcome following endoscopic fundal variceal ligation. Gastrointest Endosc 43 1 (1996) 82
176. Sarin S.K., Jain A.K., Jain M., et al. A randomized controlled trial of cyanoacrylate versus alcohol injection in patients with isolated fundic varices. Am J Gastroenterol 97 4 (2002) 1010-1015
177. Lo G.H., Lai K.H., Cheng J.S., et al. A prospective, randomized trial of butyl cyanoacrylate injection versus band ligation in the management of bleeding gastric varices. Hepatology 33 5 (2001) 1060-1064
178. Tan P.C., Hou M.C., Lin H.C., et al. A randomized trial of endoscopic treatment of acute gastric variceal hemorrhage: N-butyl-2-cyanoacrylate injection versus band ligation. Hepatology 43 4 (2006) 690-697
179. Rengstorff D.S., and Binmoeller K.F. A pilot study of 2-octyl cyanoacrylate injection for treatment of gastric fundal varices in humans. Gastrointest Endosc 59 4 (2004) 553-558
180. Boyer T.D. Transjugular intrahepatic portosystemic shunt: current status. Gastroenterology 124 6 (2003) 1700-1710
181. Kanagawa H., Mima S., Kouyama H., et al. Treatment of gastric fundal varices by balloon-occluded retrograde transvenous obliteration. J Gastroenterol Hepatol 11 1 (1996) 51-58
182. Chikamori F., Kuniyoshi N., Shibuya S., et al. Eight years of experience with transjugular retrograde obliteration for gastric varices with gastrorenal shunts. Surgery 129 4 (2001) 414-420
183. Shiba M., Higuchi K., Nakamura K., et al. Efficacy and safety of balloon-occluded endoscopic injection sclerotherapy as a prophylactic treatment for high-risk gastric fundal varices: a prospective, randomized, comparative clinical trial. Gastrointest Endosc 56 4 (2002) 522-528
184. Yoshida H., Mamada Y., Taniai N., et al. New methods for the management of gastric varices. World J Gastroenterol 12 37 (2006) 5926-5931