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Volumn 33, Issue 6, 2007, Pages 1085-1093

The effect of activated protein C on plasma cytokine levels in a porcine model of acute endotoxemia

Author keywords

Cytokines; Drotrecogin alfa; Endotoxemia; Protein C; Sepsis; Systemic inflammatory response syndrome

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; DROTRECOGIN; INTERLEUKIN 10; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; TUMOR NECROSIS FACTOR ALPHA;

EID: 34249735244     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-007-0631-1     Document Type: Article
Times cited : (19)

References (36)
  • 1
    • 1942500845 scopus 로고    scopus 로고
    • EPISEPSIS: A reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units
    • Brun-Buisson C, Meshaka P, Pinton P, Vallet B (2004) EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 30:580-588
    • (2004) Intensive Care Med , vol.30 , pp. 580-588
    • Brun-Buisson, C.1    Meshaka, P.2    Pinton, P.3    Vallet, B.4
  • 2
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 5
    • 2342419017 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in an infant with gram-negative septic shock
    • Sajan I, Da-Silva SS, Dellinger RP (2004) Drotrecogin alfa (activated) in an infant with gram-negative septic shock. J Intensive Care Med 19:51-55
    • (2004) J Intensive Care Med , vol.19 , pp. 51-55
    • Sajan, I.1    Da-Silva, S.S.2    Dellinger, R.P.3
  • 6
    • 0034548822 scopus 로고    scopus 로고
    • An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia
    • White B, Livingstone W, Murphy C, Hodgson A, Rafferty M, Smith OP (2000) An open-label study of the role of adjuvant hemostatic support with protein C replacement therapy in purpura fulminans-associated meningococcemia. Blood 96:3719-3724
    • (2000) Blood , vol.96 , pp. 3719-3724
    • White, B.1    Livingstone, W.2    Murphy, C.3    Hodgson, A.4    Rafferty, M.5    Smith, O.P.6
  • 9
    • 27944477188 scopus 로고    scopus 로고
    • Activated protein C: Do more survive?
    • Mackenzie AF (2005) Activated protein C: do more survive? Intensive Care Med 31:1624-1626
    • (2005) Intensive Care Med , vol.31 , pp. 1624-1626
    • MacKenzie, A.F.1
  • 10
    • 33645099809 scopus 로고    scopus 로고
    • Sepsis in the ICU: Who needs progress?
    • Vincent JL (2006) Sepsis in the ICU: who needs progress? Intensive Care Med 32:609
    • (2006) Intensive Care Med , vol.32 , pp. 609
    • Vincent, J.L.1
  • 16
    • 0032196478 scopus 로고    scopus 로고
    • Effects of a combined antithrombin III and protein C supplementation in porcine acute endotoxic shock
    • Fourrier F, Jourdain M, Tournoys A, Gosset P, Mangalaboyi J, Chopin C (1998) Effects of a combined antithrombin III and protein C supplementation in porcine acute endotoxic shock. Shock 10:364-370
    • (1998) Shock , vol.10 , pp. 364-370
    • Fourrier, F.1    Jourdain, M.2    Tournoys, A.3    Gosset, P.4    Mangalaboyi, J.5    Chopin, C.6
  • 18
    • 33646893270 scopus 로고    scopus 로고
    • Cardiovascular protective role for activated protein C during endotoxemia in rats
    • Favory R, Lancel S, Chal X, Tissier S, Neviere R (2006) Cardiovascular protective role for activated protein C during endotoxemia in rats. Intensive Care Med 32:899-905
    • (2006) Intensive Care Med , vol.32 , pp. 899-905
    • Favory, R.1    Lancel, S.2    Chal, X.3    Tissier, S.4    Neviere, R.5
  • 20
    • 29244446219 scopus 로고    scopus 로고
    • The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia
    • Spiel AO, Firbas C, Mayr FB, Leitner JM, Schmidt B, Knobl P, Varadi K, Jilma B (2005) The effects of supra-normal protein C levels on markers of coagulation, fibrinolysis and inflammation in a human model of endotoxemia. Thromb Haemost 94:1148-1155
    • (2005) Thromb Haemost , vol.94 , pp. 1148-1155
    • Spiel, A.O.1    Firbas, C.2    Mayr, F.B.3    Leitner, J.M.4    Schmidt, B.5    Knobl, P.6    Varadi, K.7    Jilma, B.8
  • 21
    • 0141567620 scopus 로고    scopus 로고
    • Recombinant human activated protein C (rhAPC drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia
    • Derhaschnig U, Reiter R, Knobl P, Baumgartner M, Keen P, Jilma B (2003) Recombinant human activated protein C (rhAPC drotrecogin alfa [activated]) has minimal effect on markers of coagulation, fibrinolysis, and inflammation in acute human endotoxemia. Blood 102:2093-2098
    • (2003) Blood , vol.102 , pp. 2093-2098
    • Derhaschnig, U.1    Reiter, R.2    Knobl, P.3    Baumgartner, M.4    Keen, P.5    Jilma, B.6
  • 23
    • 2942746318 scopus 로고    scopus 로고
    • Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling
    • Zeng W, Matter WF, Yan SB, Um SL, Vlahos CJ, Liu L (2004) Effect of drotrecogin alfa (activated) on human endothelial cell permeability and Rho kinase signaling. Crit Care Med 32:S302-S308
    • (2004) Crit Care Med , vol.32
    • Zeng, W.1    Matter, W.F.2    Yan, S.B.3    Um, S.L.4    Vlahos, C.J.5    Liu, L.6
  • 24
    • 0033880884 scopus 로고    scopus 로고
    • Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line
    • White B, Schmidt M, Murphy C, Livingstone W, O'Toole D, Lawler M, O'Neill L, Kelleher D, Schwarz HP, Smith OP (2000) Activated protein C inhibits lipopolysaccharide-induced nuclear translocation of nuclear factor kappaB (NF-kappaB) and tumour necrosis factor alpha (TNF-alpha) production in the THP-1 monocytic cell line. Br J Haematol 110:130-134
    • (2000) Br J Haematol , vol.110 , pp. 130-134
    • White, B.1    Schmidt, M.2    Murphy, C.3    Livingstone, W.4    O'Toole, D.5    Lawler, M.6    O'Neill, L.7    Kelleher, D.8    Schwarz, H.P.9    Smith, O.P.10
  • 25
    • 0035815747 scopus 로고    scopus 로고
    • Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis
    • Joyce DE, Gelbert L, Ciaccia A, DeHoff B, Grinnell BW (2001) Gene expression profile of antithrombotic protein c defines new mechanisms modulating inflammation and apoptosis. J Biol Chem 276:11199-11203
    • (2001) J Biol Chem , vol.276 , pp. 11199-11203
    • Joyce, D.E.1    Gelbert, L.2    Ciaccia, A.3    Dehoff, B.4    Grinnell, B.W.5
  • 26
    • 0029626658 scopus 로고
    • Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses
    • Hancock WW, Grey ST, Hau L, Akalin E, Orthner C, Sayegh MH, Salem HH (1995) Binding of activated protein C to a specific receptor on human mononuclear phagocytes inhibits intracellular calcium signaling and monocyte-dependent proliferative responses. Transplantation 60:1525-1532
    • (1995) Transplantation , vol.60 , pp. 1525-1532
    • Hancock, W.W.1    Grey, S.T.2    Hau, L.3    Akalin, E.4    Orthner, C.5    Sayegh, M.H.6    Salem, H.H.7
  • 27
    • 0027998013 scopus 로고
    • Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester
    • Grey ST, Tsuchida A, Hau H, Orthner CL, Salem HH, Hancock WW (1994) Selective inhibitory effects of the anticoagulant activated protein C on the responses of human mononuclear phagocytes to LPS, IFN-gamma, or phorbol ester. J Immunol 153:3664-3672
    • (1994) J Immunol , vol.153 , pp. 3664-3672
    • Grey, S.T.1    Tsuchida, A.2    Hau, H.3    Orthner, C.L.4    Salem, H.H.5    Hancock, W.W.6
  • 29
    • 0028299926 scopus 로고
    • Human protein C inhibits selectin-mediated cell adhesion: Role of unique fucosylated oligosaccharide
    • Grinnell BW, Hermann RB, Yan SB (1994) Human protein C inhibits selectin-mediated cell adhesion: role of unique fucosylated oligosaccharide. Glycobiology 4:221-225
    • (1994) Glycobiology , vol.4 , pp. 221-225
    • Grinnell, B.W.1    Hermann, R.B.2    Yan, S.B.3
  • 31
    • 0022910521 scopus 로고
    • Mechanism of protein C-dependent clot lysis: Role of plasminogen activator inhibitor
    • Sakata Y, Loskutoff DJ, Gladson CL, Hekman CM, Griffin JH (1986) Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood 68:1218-1223
    • (1986) Blood , vol.68 , pp. 1218-1223
    • Sakata, Y.1    Loskutoff, D.J.2    Gladson, C.L.3    Hekman, C.M.4    Griffin, J.H.5
  • 32
    • 0029793068 scopus 로고    scopus 로고
    • The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent
    • Bajzar L, Nesheim ME, Tracy PB (1996) The profibrinolytic effect of activated protein C in clots formed from plasma is TAFI-dependent. Blood 88:2093-2100
    • (1996) Blood , vol.88 , pp. 2093-2100
    • Bajzar, L.1    Nesheim, M.E.2    Tracy, P.B.3
  • 33
    • 1542544890 scopus 로고    scopus 로고
    • Activated protein C attenuates coagulation-associated over-expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1
    • Urano T, Castellino FJ, Ihara H, Suzuki Y, Ohta M, Suzuki K, Mogami H (2003) Activated protein C attenuates coagulation-associated over-expression of fibrinolytic activity by suppressing the thrombin-dependent inactivation of PAI-1. J Thromb Haemost 1:2615-2620
    • (2003) J Thromb Haemost , vol.1 , pp. 2615-2620
    • Urano, T.1    Castellino, F.J.2    Ihara, H.3    Suzuki, Y.4    Ohta, M.5    Suzuki, K.6    Mogami, H.7
  • 34
    • 0036120986 scopus 로고    scopus 로고
    • Usefulness of human coagulation and fibrinolysis assays in domestic pigs
    • Munster AM, Olsen AK, Bladbjerg EM (2002) Usefulness of human coagulation and fibrinolysis assays in domestic pigs. Comp Med 52:39-43
    • (2002) Comp Med , vol.52 , pp. 39-43
    • Munster, A.M.1    Olsen, A.K.2    Bladbjerg, E.M.3
  • 35
    • 2942755759 scopus 로고    scopus 로고
    • Why do animal models (sometimes) fail to mimic human sepsis?
    • Esmon CT (2004) Why do animal models (sometimes) fail to mimic human sepsis? Crit Care Med 32:S219-S222
    • (2004) Crit Care Med , vol.32
    • Esmon, C.T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.