Determination of lidocaine and its two N-desethylated metabolites in dog and horse plasma by high-performance liquid chromatography combined with electrospray ionization tandem mass spectrometry

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 180-187

  Maes, A ^a   Weiland, L ^a   Sandersen, C ^b   Gasthuys, F ^a   De Backer, P ^a   Croubels, S ^a  

^a GHENT UNIVERSITY   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Dog plasma; Glycinexylidide; Horse plasma; Lidocaine; Liquid chromatography electrospray ionization tandem mass spectrometry; Monoethylglycinexylidide; Quantification; Validation

Indexed keywords

GLYCINEXYLIDIDE; LIDOCAINE; LIQUID-LIQUID EXTRACTION; MONOETHYLGLYCINEXYLIDIDE; QUANTIFICATION;

ANIMALS; BLOOD; ELECTROSPRAY IONIZATION; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

METABOLITES;

2 (N ETHYL N METHYLAMINO) 2',6' ACETOXYLIDIDE; ACETONITRILE; AMMONIUM ACETATE; DEETHYLLIDOCAINE; GLYCINE XYLIDIDE; LIDOCAINE; SODIUM HYDROXIDE; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; ELECTROSPRAY MASS SPECTROMETRY; ELUTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; LIQUID LIQUID EXTRACTION; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOGS; HORSES; LIDOCAINE; REFERENCE STANDARDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

ANIMALIA; CANIS FAMILIARIS; EQUIDAE;

EID: 34249703556     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.01.010     Document Type: Article

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