In vitro and in vivo comparative study of intraconazole bioavailability when formulated in highly soluble self-emulsifying system and in solid dispersion

Biopharmaceutics and Drug Disposition

Volumn 28, Issue 4, 2007, Pages 199-207

  Park, Mi Jin ^a   Ren, Shan ^a   Lee, Beom Jin ^a,b  

^a Kangwon National University   (South Korea)

^b Pharm Tech Research Inc   (South Korea)

Author keywords

Bioavailability; Comparative disposition; Peyer's patches; Self emulsifying system (SES); Solid dispersion (SD)

Indexed keywords

CITRIC ACID; HYDROXYPROPYLMETHYLCELLULOSE; ITRACONAZOLE; OLEIC ACID; POLYSORBATE 80;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG DISPOSITION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG UPTAKE; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; INTESTINE; INTESTINE FLUID; LIVER; LIVER CELL; MALE; MAXIMUM PLASMA CONCENTRATION; MICROEMULSION; NONHUMAN; PEYER PATCH; PLASMA CONCENTRATION-TIME CURVE; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SOLID STATE; STOMACH JUICE; STOMACH PH; TISSUE INJURY;

ANIMALS; ANTIFUNGAL AGENTS; AREA UNDER CURVE; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; EMULSIONS; HALF-LIFE; INTESTINES; ITRACONAZOLE; MALE; PEYER'S PATCHES; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 34249690584     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.546     Document Type: Article

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