TNF Polymorphism and Cardiovascular Disease: TNF gene polymorphism and quantitative traits related to cardiovascular disease: Getting to the heart of the matter

European Journal of Human Genetics

Volumn 15, Issue 6, 2007, Pages 609-611

  Mellick, George D ^a  

^a GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR ALPHA; TNF PROTEIN, HUMAN; UNCLASSIFIED DRUG;

ALLELE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENE LOCUS; GENE SEQUENCE; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOME; GENOTYPE; HAPLOTYPE; HEART INFARCTION; HUMAN; MOLECULAR MECHANICS; NOTE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; QUANTITATIVE TRAIT; GENETICS; PHYSIOLOGY;

CARDIOVASCULAR DISEASES; HUMANS; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYMORPHISM, GENETIC; QUANTITATIVE TRAIT, HERITABLE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 34249682809     PISSN: 10184813     EISSN: 14765438     Source Type: Journal    
DOI: 10.1038/sj.ejhg.5201816     Document Type: Note

References (19)

1. Weiss KM, Terwilliger JD: How many diseases does it take to map a gene with SNPs? Nat Genet 2000; 26: 151-157.
2. Terwilliger JD, Hiekkalinna T: An utter refutation of the 'Fundamental Theorem of the HapMap'. Eur J Hum Genet 2006; 14: 426-437.
3. Buchanan AV, Weiss KM,TFullerton SM: Dissecting complex disease: the quest for the Philosopher's Stone? Int J Epidemiol 2006; 35: 562-571.
4. Stranger BE, Forrest MS, Clark AG et al: Genome-wide associations of gene expression variation in humans. PLoS Genet 2005; 1: e78.
5. Spielman RS, Bastone LA, Burdick JT, Morley M, Ewens WJ, Cheung VG: Common genetic variants account for differences in gene expression among ethnic groups. Nat Genet 2007; 39: 226-231.
6. Hong MG, Bennet AM, de Faire U, Prince JA: Phenotype selection for detecting variable genes: A survey of cardiovascular quantitative traits and TNF locus polymorphism. Eur J Hum Genet 2007; 15: 685-693.
7. Skoog T, van't Hooft FM, Kallin B et al: A common functional polymorphism (C- > A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha. Hum Mol Genet 1999; 8: 1443-1449.
8. Sharma S, Sharma A, Kumar S, Sharma SK, Ghosh B: Association of TNF haplotypes with asthma, serum IgE levels, and correlation with serum TNF-alpha levels. Am J Respir Cell Mol Biol 2006; 35: 488-495.
9. Skoog T, Hamsten A, Eriksson P: Allele-specific chromatin remodeling of the tumor necrosis factor-alpha promoter. Biochem Biophys Res Commun 2006; 351: 777-783.
10. van Heel DA, Udalova IA, De Silva AP et al: Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors. Hum Mol Genet 2002; 11: 1281-1289.
11. Bennet AM, van Maarle MC, Hallqvist J et al: Association of TNF-alpha serum levels and TNFA promoter polymorphisms with risk of myocardial infarction. Atherosclerosis 2006; 187: 408-414.
12. Leander K, Wiman B, Hallqvist J, Sten-Linder M, de Faire U: PAI-1 level and the PAI-1 4G/5G polymorphism in relation to risk of non-fatal myocardial infarction: Results from the Stockholm Heart Epidemiology Program (SHEEP). Thromb Haemost 2003; 89: 1064-1071.
13. Dawson SJ, Wiman B, Hamsten A, Green F, Humphries S, Henney AM: The two allele sequences of a common polymorphism in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene respond differently to interleukin-1 in HepG2 cells. J Biol Chem 1993; 268: 10739-10745.
14. Pandey M, Loskutoff DJ, Samad F: Molecular mechanisms of tumor necrosis factor-alpha-mediated plasminogen activator inhibitor-1 expression in adipocytes. FASEB J 2005; 19: 1317-1319.
15. Ulfhammer E, Larsson P, Karlsson L et al: TNF-alpha mediated suppression of tissue type plasminogen activator expression in vascular endothelial cells is NF-kappaB and p38 MAPK-dependent. J Thrumb Haemost 2006; 4: 1781-1789.
16. Ozaki K, Ohnishi Y, Iida A et al: Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Nat Genet 2002; 32: 650-654.
17. Yamada A, Ichihara S, Murase Y et al: Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese. J Mol Med 2004; 82: 477-483.
18. Smith GD, Ebrahim SP Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004; 33: 30-42.
19. Davey Smith G, Ebrahim. S, Lewis S, Hansell AL, Palmer LJ, Burton PR: Genetic epidemiology and public health: Hope, hype, and future prospects. Lancet 2005; 366: 1484-1498.