Chronic amantadine treatment enhances the sexual behaviour of male rats

Pharmacology Biochemistry and Behavior

Volumn 86, Issue 4, 2007, Pages 616-621

  Ferraz, Marcia Martins Dias ^a   Fontanella, Julia Cordeiro ^a   Damasceno, Fabio ^a   Silva de Almeida, Olga Maria Martins ^a   Ferraz, Marcos Rochedo ^a  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

Amantadine; Dopamine; Sex; Sexual arousal; Sexual behaviour; Sexual behaviour temporal patterning

Indexed keywords

AMANTADINE;

ANIMAL EXPERIMENT; AROUSAL; ARTICLE; CONTROLLED STUDY; COPULATION; DRUG EFFECT; DRUG EFFICACY; DRUG MEGADOSE; DRUG TOLERANCE; EJACULATION; LIBIDO; LONG TERM CARE; LOW DRUG DOSE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SEXUAL BEHAVIOR;

AMANTADINE; ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIPARKINSON AGENTS; ANTIPSYCHOTIC AGENTS; DOPAMINE AGONISTS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; SEXUAL BEHAVIOR; SEXUAL BEHAVIOR, ANIMAL;

PARKINSONIA; RATTUS;

EID: 34249663883     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2007.02.003     Document Type: Article

References (31)

1. Aizenberg D., Modai I., Landa A., Gil-Ad I., and Weizman A. Comparison of sexual dysfunction in male schizophrenic patients maintained on treatment with classical antipsychotics versus clozapine. J Clin Psychiatry 62 7 (2001) 541-544
2. Allers K.A., Bergstrom D.A., Ghazi L.J., Kreiss D.S., and Walters J.R. MK801 and amantadine exert different effects on subthalamic neuronal activity in a rodent model of Parkinson's disease. Exp Neurol 191 1 (2005) 104-118
3. Baraldi M., and Bertolini A. Penile erection induced by amantadine in male rats. Life Sci 14 (1974) 1231-1235
4. Biachi C., and Tomasi L. Central nervous system and autonomic nervous system effects of amantadine and some standard anti-Parkinson drugs. Pharmacology 10 (1973) 226-237
5. Bibbiani F., Oh J.D., Kielaite A., Collins M.A., Smith C., and Chase T.N. Combined blockade of AMPA and NMDA glutamate receptors reduces levodopa-induced motor complications in animal models of PD. Exp Neurol 196 2 (2005) 422-429
6. Bitran D., and Hull E.M. Pharmacological analysis of male rat sexual behaviour. Neurosci Biobehv Rev 11 (1987) 365-389
7. Bitran D., Hull E.M., Holmes G.M., and Lookingland K.J. Regulation of male rat copulatory behaviour by preoptic incertohypothalamic dopamine neurons. Brain Res Bull 20 (1988) 323-331
8. Charles M.A., and McGinnis M.Y. Effects of Ly 163502, a D2 dopaminergic agonist, on the sexual behaviour of male rats. Pharmacol Biochem Behav 43 (1992) 1087-1092
9. Damsma G., Pfaus J.G., Wenkstern D., Phillips A.G., and Fibiger H.C. Sexual behaviour increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. Behav Sci 1056 1 (1992) 181-191
10. Du J., Lorrain D.S., Hull E.M., and Matuszewich L. Castration decreases extracellular, but increases intracellular, dopamine in medial preoptic area of male rats. Brain Res Bull 782 1-2 (1997) 11-17
11. Ferrari F., Ottani A., and Giuliani D. Influence of sildenafil on central dopamine-mediated behaviour in male rats. Life Sci 70 13 (2002) 1501-1508
12. Ferraz M.R., and Santos R. Amantadine stimulates sexual behaviour in male rats. Pharmacol Biochem Behav 51 (1995) 709-714
13. Ferraz M.R., Ferraz M.M.D., and Santos R. How REM sleep deprivation and amantadine affects male rat sexual behaviour. Pharmacol Biochem Behav 69 (2001) 325-332
14. Ferraz M.R., Ferraz M.M.D., Santos R., and Moura R.S. Preventing L-NAME inhibitory effects on rat sexual behavior with hydralazine, isradipine or captopril co-treatment. Pharmacol Biochem Behav 75 (2003) 265-272
15. Graham K.A., Gu H., Lieberman J.A., Harp J.B., and Perkins D.O. Double-blind, placebo-controlled investigation of amantadine for weight loss in subjects who gained weight with olanzapine. Am J Psychiatry 162 9 (2005) 1744-1746
16. Huber T.J., Dietrich D.E., and Emrich H.M. Possible use of amantadine in depression. Pharmacopsychiatry 32 2 (1999) 47-55
17. Hull E.M., Du J., Lorrais D.S., and Matuszewich L. Testosterone, preoptic dopamine, and copulation in male rats. Brain Res Bull 44 4 (1997) 327-333
18. Mellis R.R., and Argiolas A. Dopamine and sexual behavior. Neurosci Biobehav Rev 19 1 (1995) 19-38
19. Owen J.C.E., and Whitton P.S. Effects of amantadine and budipine on antidepressant drug-evoked changes in extracellular 5-HT in the frontal cortex of freely moving rats. Br J Pharmacol 145 (2005) 587-592
20. Peeters M., Page G., Maloteaux J.M., and Hermans E. Hypersensitivity of dopamine transmission in the rat striatum after treatment with the NMDA receptor antagonist amantadine. Brain Res 949 1-2 (2002) 32-41
21. Pehek E.A., Warner R.K., Bazzett T.J., Bitran D., Band L.C., Eaton R.C., et al. Microinjection of cis-flupenthixol, a dopamine antagonist, into the medial preoptic area impairs sexual behaviour of the male rat. Brain Res 443 (1988) 70-76
22. Pereira da Silva-Junior F., Braga-Neto P., Sueli Monte F., and Meireles Sales de Bruin V. Amantadine reduces the duration of levodopa-induced dyskinesia: a randomized, double-blind, placebo-controlled study. Parkinsonism Relat Disord 11 7 (2005) 449-452
23. Petrie W.M. Sexual effects of antidepressants and psychomotor stimulant drugs. Mod Probl Pharmacopxycohol 15 (1985) 77-90
24. Pfaus J.G., and Phillips A.G. Role of dopamine in anticipatory and consummatory aspects of sexual behaviour in the male rat. Behav. Biosci. 105 (1991) 727-743
25. Sachs B.D. Conceptual and neural mechanisms of masculine copulatory behaviour. In: McGill T.E., Dewsbury D.A., and Sachs B.D. (Eds). Sex and behaviour: status and prospectus (1978), Plenum Press, New York 267-295
26. Sachs B.D., and Barfield R.T. Temporal patterning of sexual behaviour in the male rat. J Comp Physiol Psych 73 (1970) 359-364
27. Shrivastava R.K., Shrivastava S., Overweg N., and Schmitt M. Amantadine in the treatment of sexual dysfunction associated with selective serotonin reuptake inhibitors. J Clin Psychopharmacol 15 1 (1995) 83-84
28. Stoof J.C., Booij J., and Drukarch B. Amantadine as N-methyl-d-aspartic acid receptor antagonist: new possibilities for therapeutic applications?. Clin Neurol Neurossurg 213 (1992) 439-443
29. Stryjer R., Strous R.D., Shaked G., Bar F., Feldman B., Kotler M., et al. Amantadine as augmentation therapy in the management of treatment-resistant depression. Int Clin Psychopharmacol 18 2 (2003) 93-96
30. Wirshing D.A., Pierre J.M., Marder S.R., Saunders C.S., and Wirshing W.C. Sexual side effects of novel antipsychotic medications. Schizophr Res 56 1-2 (2002) 25-30
31. Yells D.P., Prendergast M.A., Hendricks S.E., and Miller M.E. Monoaminergic influences on temporal patterning of sexual behaviour in male rats. Physiol Behav 58 (1995) 847-852