Development and validation of a liquid chromatography-tandem mass spectrometric method for the determination of the major metabolites of duloxetine in human plasma

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 852, Issue 1-2, 2007, Pages 582-589

  Satonin, Darlene K ^a   McCulloch, Julie D ^a   Kuo, Fengjiun ^a   Knadler, Mary Pat ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Duloxetine metabolites; Plasma assay; Validation

Indexed keywords

DULOXETINE METABOLITES; GLUCURONIDE ISOMERS; PLASMA ASSAY;

ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; PHARMACOKINETICS; PLASMA (HUMAN);

DRUG PRODUCTS;

4 HYDROXY DULOXETINE GLUCORONIDE; 5 HYDROXY 6 METHOXY DULOXETINE SULFATE; DULOXETINE; LY 550408; LY 581920; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; IONIZATION; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; TANDEM MASS SPECTROMETRY; VALIDATION PROCESS;

ANTIDEPRESSIVE AGENTS; CHROMATOGRAPHY, LIQUID; HUMANS; TANDEM MASS SPECTROMETRY; THIOPHENES;

EID: 34249653590     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2007.02.025     Document Type: Article

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