Level of expression of parathyroid hormone related protein and its receptor in human breast cancer and its correlation with the clinical outcome

International Journal of Cancer Research

Volumn 3, Issue 2, 2007, Pages 92-102

  Zia, Mohammad K ^a   Rmali, Khaled A ^a   Mansel, Robert E ^a   Jiang, Wen G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Breast cancer; Clinical outcome; Parathyroid hormone related protein

Indexed keywords

COMPLEMENTARY DNA; MESSENGER RNA; PARATHYROID HORMONE RELATED PROTEIN; PARATHYROID HORMONE RELATED PROTEIN RECEPTOR; RNA;

ARTICLE; BREAST CANCER; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER CLASSIFICATION; CANCER GRADING; CANCER GROWTH; CANCER MORTALITY; CANCER RELAPSE; CANCER STAGING; CANCER SURVIVAL; CELL NUCLEUS; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPLASM; DNA SYNTHESIS; FOLLOW UP; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; METASTASIS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA EXTRACTION; STATISTICAL SIGNIFICANCE; TISSUE DISTRIBUTION;

EID: 34249338720     PISSN: 18119727     EISSN: 18119735     Source Type: Journal    
DOI: 10.3923/ijcr.2007.92.102     Document Type: Article

References (35)

1. Body, JT, 2001. Bisphosphonates in the treatment of metastatic breast cancer. J. Mammary Gland Biol. Neoplasia., 6: 477-485.
2. Cataisson, C., M. Lieberherr, M. Cross, C. Gauville, A.M. Graulet, J. Cotton, F. Calvo, M.C. de Vernejoul, J. Foley and Z. Bouizar, 2000. Parathyroid hormone-related peptide stimulates proliferation of highly tumorigenic human SV 40-immortalized breast epithelial cells. J. Bone Miner Res., 15: 2129-2139.
3. Cross, M., C. Cataisson, Y.M. Cho, Y. Berthois, O. Bernard-Poenaru, M. Denne, A.M. Graulet, M.C. De Vernejoul and J. Foley, 2002. Constitutive production of parathyroid hormone-related protein (PTHrP) by fibroblasts derived from normal and pathological human breast tissue. Oncol. Res., 13: 137-146.
4. DeMauro, S., J. and Wysolmerski, 2005. Hypercalcemia in breast cancer: An echo of bone mobilization during lactation? J Mammary Gland Biol. Neoplasia., 10: 157-167.
5. Devys, A., A. Lortholary and A. Audran, 2001. PTHrP and breast cancer. Bull. Cancer, 88: 1075-1080.
6. Downey, S. E., J. Hoyland, A.J. Freemont, F. Knox and J. Walls, 1997. Expression of the receptor for parathyroid hormone-related protein in normal and malignant breast tissue. J. Pathol., 183: 212-217.
7. Dunbar, M.E. and J.J. Wysolmerski, 1999. Parathyroid hormone-related protein: A developmental regulatory molecule necessary for mammary gland development. J. Mammary Gland Biol. Neoplasia, 4: 21-34.
8. Falzon, M. and P. Du, 2000. Enhanced growth of MCF-7 breast cancer cells overexpressing parathyroid hormone-related peptide. Endocrinology, 141: 1882-1892.
9. Funk, J.L. and H. Wei, 1998. Regulation of parathyroid hormone-related protein expression in MCF-7 breast carcinoma cells by estrogen and antiestrogens. Biochem. Biophys. Res. Commun., 251: 849-854.
10. Gallwitz, W.E., T.A. Guise and G.R. Mundy, 2002. Guanosine nucleotides inhibit different syndromes of PTHrP excess caused by human cancers in vivo. J. Clin. Invest., 110: 1559-1572.
11. Guise, T.A. and G.R. Mundy, 1996. Physiological and pathological roles of parathyroid hormone-related peptide. Curr. Opin. Nephrol. Hypertens., 5: 307-315.
12. Guise, T.A., 1997. Parathyroid hormone-related protein and bone metastases. Cancer, 80: 1572-1580.
13. Guise, T.A., W.M. Kozlow, A. Heras-Herzig, S.S. Padalecki, J.J. Yin and J.M. Chirgwin, 2005. Molecular mechanisms of breast cancer metastases to bone. Clin. Breast. Cancer, 5: 46-53.
14. Henderson, M.A., J.A. Danks, J.L. Slavin, G.B. Byrnes, P.F. Choong, J.B. Spillane, J.L. Hopper and T.J. Martin, 2006. Parathyroid hormone-related protein localization in breast cancers predict improved prognosis. Cancer Res., 66: 2250-2256
15. Hoey, R.P., C. Sanderson, J. Iddon, G. Brady, N.J. Bundred and N.G. Anderson, 2003. The parathyroid hormone-related protein receptor is expressed in breast cancer bone metastases and promotes autocrine proliferation in breast carcinoma cells. Br. J. Cancer, 88: 567-573.
16. Iezzoni, J.C., M.E. Bruns, H.F. Frierson, M.G. Scott, R.A. Pence, L.J. Deftos and D.E. Bruns, 1998. Coexpression of parathyroid hormone-related protein and its receptor in breast carcinoma: A potential autocrine effector system. Mod. Pathol., 11: 265-270.
17. Kozlow, W. and T.A. Guise, 2005. Breast cancer metastasis to bone: Mechanisms of osteolysis and implications for therapy. J. Mammary Gland Biol. Neoplasia., 10: 169-180.
18. Linforth, R., N. Anderson, R. Hoey, T. Nolan, S. Downey, G. Brady, L. Ashcroft and N. Bundred, 2002. Coexpression of parathyroid hormone related protein and its receptor in early breast cancer predicts poor patient survival. Clin. Cancer Res., 8: 3172-3177.
19. Mansel, R.E., N.I. Khonji and D.Clarke, 2000. History, present status and future of sentinel node biopsy in breast cancer. The Mary Beves Lecture. Acta Oncologica, 39: 265-268.
20. Martin, T.A., G. Watkins and W.G. Jaing, 2005. KiSS-1 expression in human breast cancer. Clin. Exp. Metastasis, 22: 503-511.
21. Martin T,J., J.M. Moseley and E. D. Williams, 1997. Parathyroid hormone-related protein: Hormone and cytokine. J. Endocrinol., 154: 23-37.
22. Martin, T.J. and J.M. Moseley, 2000. Mechanisms in the skeletal complications of breast cancer. Endocr. Relat Cancer, 7: 271-284.
23. Martin, C. and B. Cutuli, 2002. Predictive model of axillary lymph node involvement in women with small invasive breast carcinoma: Axillary metastases in breast carcinoma. Cancer, 94: 314-322.
24. Massfelder, T. and J.J. Helwig, 2003. The parathyroid hormone-related protein system: More data but more unsolved questions. Curr. Opion. Nephrol. Hypertens., 12: 34-42.
25. Philbrick, W.M., J.J. Wysolmerski, S. Galbraith, E. Holt, J.J. Orloff and K.H. Yang, 1996. Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol. Rev., 76: 127-173.
26. Powell, G.J., J. Southby, J.A. Danks, R.G. Stillwell, J.A. Hayman, M.A. Henderson, R.C. Bennett and T.J. Martin, 1991. Localization of parathyroid hormone-related protein in breast cancer metastases: Increased incidence in bone compared with other sites. Cancer Res., 51: 3059-3061.
27. Rabbani, S.A., P. Khalili, A. Arakelian, H. Pizzi, G. Chen and D. Goltzman, 2005. Regulation of parathyroid hormone-related peptide by estradiol: Effect on tumor growth and metastasis in vitro and in vivo. Endocrinology, 146: 2885-2894.
28. Rong, H.H., Ji J.A. Tsai, Y. Pernow and E. Bucht, 1999. Calcitonin-suppressed expression of parathyroid hormone-related protein in breast cancer cells. Biochem. Biophys. Res. Commun., 265: 260-264.
29. Shen, X.L. Qian and M. Falzon, 2004. PTH-related protein enhances MCF-7 breast cancer cell adhesion, migration and invasion via an intracrine pathway. Exp. Cell Res., 294: 420-433.
30. Solimando, D.A., 2001. Overview of hypercalcemia of malignancy. Am. J. Health Syst. Pharm., 58: 4-7.
31. Sugimoto, T.E. Shiba, T. Watanabe and S. Takai, 1999. Suppression of parathyroid hormone-related protein messenger RNA expression by medroxyprogesterone acetate in breast cancer tissues. Breast Cancer Res. Treat., 56: 11-23.
32. Tabuenca, A.S. Mohan, C.A. Garberoglio, P.I. Borgen, T. Rosol and T.A. Linkhart, 1995. Parathyroid hormone-related protein: primary osteolytic factor produced by breast tumor cells in vitro? World J. Surg., 19: 292-297.
33. Valagussa, P., G. Bonadorma and U. Veronesi, 1978. Patterns of relapse and survival following radical mastectomy. Cancer, 41: 1170.
34. Vargas, S.J., M.T. Gillespie, G.J. Powell, J. Southby, J.A. Danks, J.M. Moseley and T.J. Martin, 1992. Localization of parathyroid hormone-related protein mRNA expression in breast cancer and metastatic lesions by in situ hybridization. J. Bone Miner Res., 7: 971-979.
35. Yoshida, A., Y. Nakamura, A. Shimizu, M. Harada, Y. Kameda, A. Nagano, M. Inaba and T. Asaga, 2000. Significance of the parathyroid hormone-related protein expression in breast carcinoma. Breast Cancer Res. Treat., 7: 215-220.