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Volumn 3, Issue 2, 2007, Pages 117-131

Cellular and molecular regulation of inflammatory pain, nociception and hyperalgesia - The role of the transcription factor NF-κB as the lynchpin nocisensor: Hyperalgesic or analgesic effect?

Author keywords

Analgesia; Hyperalgesia; Inflammation; NF B; Nociception; Nocisensor; Pain; Transcription factors

Indexed keywords

ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID DERIVATIVE; ADVANCED GLYCATION END PRODUCT RECEPTOR; ANALGESIC AGENT; ARACHIDONIC ACID; BRADYKININ B1 RECEPTOR; BRADYKININ B2 RECEPTOR; DEXAMETHASONE; GALANIN RECEPTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 10; INTERLEUKIN 1BETA; MELOXICAM; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; OLIGODEOXYNUCLEOTIDE; PHOSPHOTRANSFERASE; PROSTAGLANDIN SYNTHASE; PROTEIN C FOS; PYRROLIDINE DITHIOCARBAMATE; ROFECOXIB; SALAZOSULFAPYRIDINE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR REL; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; TUMOR SUPPRESSOR PROTEIN; ZINC FINGER PROTEIN;

EID: 34249336067     PISSN: 15733955     EISSN: None     Source Type: Journal    
DOI: 10.2174/157339507780655504     Document Type: Review
Times cited : (5)

References (171)
  • 1
    • 33845906082 scopus 로고    scopus 로고
    • On the enigma of pain and hyperalgesia: A molecular perspective
    • Haddad JJ. On the enigma of pain and hyperalgesia: A molecular perspective. Biochem Biophys Res Commun 2007; 353: 217-24.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 217-224
    • Haddad, J.J.1
  • 2
    • 32244431599 scopus 로고    scopus 로고
    • Mechanisms of disease: Mechanism-based classification of neuropathic pain-a critical analysis
    • Finnerup NB, Jensen TS. Mechanisms of disease: mechanism-based classification of neuropathic pain-a critical analysis. Nat Clin Pract Neurol 2006; 2: 107-15.
    • (2006) Nat Clin Pract Neurol , vol.2 , pp. 107-115
    • Finnerup, N.B.1    Jensen, T.S.2
  • 3
    • 4644274649 scopus 로고    scopus 로고
    • Nociception in vertebrates: Key receptors participating in spinal mechanisms of chronic pain in animals
    • Garry EM, Jones E, Fleetwood-Walker SM. Nociception in vertebrates: key receptors participating in spinal mechanisms of chronic pain in animals. Brain Res Brain Res Rev 2004; 46: 216-24.
    • (2004) Brain Res Brain Res Rev , vol.46 , pp. 216-224
    • Garry, E.M.1    Jones, E.2    Fleetwood-Walker, S.M.3
  • 4
    • 34249312428 scopus 로고    scopus 로고
    • Basbaum AI, Jessell TM. The perception of pain. In: Principles of Neural Science, 4th Ed. McGraw-Hill Comp., Health Professions Division, USA. 2000; 473-91.
    • Basbaum AI, Jessell TM. The perception of pain. In: Principles of Neural Science, 4th Ed. McGraw-Hill Comp., Health Professions Division, USA. 2000; 473-91.
  • 5
    • 4243562222 scopus 로고    scopus 로고
    • Pain and neurogenic inflammation: A neural substrate for neuroendocrine-immune interactions
    • Saadé NE, Apkarian AV and Jabbur SJ Ed. New York, Kluwer Academic/Plenum Publishers
    • Saadé NE, Massaad CA, Kanaan SA, Safieh-Garabedian B, Jabbur SJ, Atweh SF. Pain and neurogenic inflammation: A neural substrate for neuroendocrine-immune interactions. In: Pain and Neuroimmune Interactions, Saadé NE, Apkarian AV and Jabbur SJ Ed. New York, Kluwer Academic/Plenum Publishers 2000; 111-23.
    • (2000) Pain and Neuroimmune Interactions , pp. 111-123
    • Saadé, N.E.1    Massaad, C.A.2    Kanaan, S.A.3    Safieh-Garabedian, B.4    Jabbur, S.J.5    Atweh, S.F.6
  • 7
    • 1842450332 scopus 로고    scopus 로고
    • Pathways that elicit long-term changes in gene expression in nociceptive neurons following nerve injury: Contributions to neuropathic pain
    • Sung YJ, Ambron RT. Pathways that elicit long-term changes in gene expression in nociceptive neurons following nerve injury: contributions to neuropathic pain. Neurol Res 2004; 26: 195-203.
    • (2004) Neurol Res , vol.26 , pp. 195-203
    • Sung, Y.J.1    Ambron, R.T.2
  • 9
    • 0036384284 scopus 로고    scopus 로고
    • Redox regulation of pro-inflammatory cytokines and IκB-α:/ NF-κB nuclear translocation and activation
    • Haddad JJ. Redox regulation of pro-inflammatory cytokines and IκB-α:/ NF-κB nuclear translocation and activation. Biochem Biophys Res Commun 2002; 296: 847-56.
    • (2002) Biochem Biophys Res Commun , vol.296 , pp. 847-856
    • Haddad, J.J.1
  • 10
    • 4544342570 scopus 로고    scopus 로고
    • Aggarwal BB. Nuclear factor-κB: The enemy within. Cancer Cell 2004; 6: 203-8.
    • Aggarwal BB. Nuclear factor-κB: The enemy within. Cancer Cell 2004; 6: 203-8.
  • 12
    • 33747819206 scopus 로고    scopus 로고
    • Regulation of NF-κB signaling by decoy oligodeoxynucleotides
    • Isomura I, Morita A. Regulation of NF-κB signaling by decoy oligodeoxynucleotides. Microbiol Immunol 2006; 50: 559-63.
    • (2006) Microbiol Immunol , vol.50 , pp. 559-563
    • Isomura, I.1    Morita, A.2
  • 13
    • 33746862576 scopus 로고    scopus 로고
    • Naturally occurring NF-κB inhibitors
    • Nam NH. Naturally occurring NF-κB inhibitors. Mini Rev Med Chem 2006; 6: 945-51.
    • (2006) Mini Rev Med Chem , vol.6 , pp. 945-951
    • Nam, N.H.1
  • 14
    • 33744825413 scopus 로고    scopus 로고
    • Nuclear factor κB is a promising therapeutic target in inflammatory lung disease
    • Park GY, Christman JW. Nuclear factor κB is a promising therapeutic target in inflammatory lung disease. Curr Drug Targets 2006; 7: 661-8.
    • (2006) Curr Drug Targets , vol.7 , pp. 661-668
    • Park, G.Y.1    Christman, J.W.2
  • 15
    • 1242296820 scopus 로고    scopus 로고
    • Specific Inhibition of IκB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats
    • Tegeder I, Niederberger E, Schmidt R, et al. Specific Inhibition of IκB kinase reduces hyperalgesia in inflammatory and neuropathic pain models in rats. J Neurosci 2004; 24: 1637-45.
    • (2004) J Neurosci , vol.24 , pp. 1637-1645
    • Tegeder, I.1    Niederberger, E.2    Schmidt, R.3
  • 17
    • 33745107825 scopus 로고    scopus 로고
    • The immune system: A new look at pain
    • Zhang JH, Huang YG. The immune system: a new look at pain. Chin Mod J (Engl) 2006; 119: 930-8.
    • (2006) Chin Mod J (Engl) , vol.119 , pp. 930-938
    • Zhang, J.H.1    Huang, Y.G.2
  • 18
    • 33744945025 scopus 로고    scopus 로고
    • Exploring the positive and negative consequences of NF-κB inhibition for the treatment of human disease
    • Fraser CC. Exploring the positive and negative consequences of NF-κB inhibition for the treatment of human disease. Cell Cycle 2006; 5: 1160-3.
    • (2006) Cell Cycle , vol.5 , pp. 1160-1163
    • Fraser, C.C.1
  • 20
    • 33745852665 scopus 로고    scopus 로고
    • Alternative pathways of NF-κB activation: A double-edged sword in health and disease
    • Xiao G, Rabson AB, Young W, Qing G, Qu Z. Alternative pathways of NF-κB activation: a double-edged sword in health and disease. Cytokine Growth Factor Rev 2006; 17: 281-93.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 281-293
    • Xiao, G.1    Rabson, A.B.2    Young, W.3    Qing, G.4    Qu, Z.5
  • 21
    • 0034728783 scopus 로고    scopus 로고
    • The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-κB (RelA)-selective targeting
    • Haddad JJ, Land SC. The differential expression of apoptosis factors in the alveolar epithelium is redox sensitive and requires NF-κB (RelA)-selective targeting. Biochem Biophys Res Commun 2000; 271: 257-67.
    • (2000) Biochem Biophys Res Commun , vol.271 , pp. 257-267
    • Haddad, J.J.1    Land, S.C.2
  • 23
    • 1342284289 scopus 로고    scopus 로고
    • Convergence of the NF-κB and interferon signaling pathways in the regulation of antiviral defense and apoptosis
    • Hiscott J, Grandvaux N, Sharma S, Tenoever BR, Servant MJ, Lin R. Convergence of the NF-κB and interferon signaling pathways in the regulation of antiviral defense and apoptosis. Ann NY Acad Sci 2003; 1010: 237-48.
    • (2003) Ann NY Acad Sci , vol.1010 , pp. 237-248
    • Hiscott, J.1    Grandvaux, N.2    Sharma, S.3    Tenoever, B.R.4    Servant, M.J.5    Lin, R.6
  • 24
    • 2342510148 scopus 로고    scopus 로고
    • Secreted transforming growth factor-β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells
    • Lu T, Burdelya LG, Swiatkowski SM, et al. Secreted transforming growth factor-β2 activates NF-κB, blocks apoptosis, and is essential for the survival of some tumor cells. Proc Natl Acad Sci USA 2004; 101: 7112-7.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 7112-7117
    • Lu, T.1    Burdelya, L.G.2    Swiatkowski, S.M.3
  • 25
    • 2442572230 scopus 로고    scopus 로고
    • Identification of a p65 peptide that selectively inhibits NF-κB activation induced by various inflammatory stimuli and its role in down-regulation of NF-κB-mediated gene expression and up-regulation of apoptosis
    • Takada Y, Singh S, Aggarwal BB. Identification of a p65 peptide that selectively inhibits NF-κB activation induced by various inflammatory stimuli and its role in down-regulation of NF-κB-mediated gene expression and up-regulation of apoptosis. J Biol Chem 2004; 279: 15096-104.
    • (2004) J Biol Chem , vol.279 , pp. 15096-15104
    • Takada, Y.1    Singh, S.2    Aggarwal, B.B.3
  • 26
    • 4143073274 scopus 로고    scopus 로고
    • Redox and oxidant-mediated regulation of apoptosis signaling pathways: Immuno-pharmaco-redox conception of oxidative siege versus cell death commitment
    • Haddad JJ. Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. Int Immunopharmacol 2004; 4: 475-93.
    • (2004) Int Immunopharmacol , vol.4 , pp. 475-493
    • Haddad, J.J.1
  • 27
    • 33646705888 scopus 로고    scopus 로고
    • NF-κB: A stress-regulated switch for cell survival
    • Piva R, Belardo G, Santoro MG. NF-κB: a stress-regulated switch for cell survival. Antioxid Redox Signal 2006; 8: 478-86.
    • (2006) Antioxid Redox Signal , vol.8 , pp. 478-486
    • Piva, R.1    Belardo, G.2    Santoro, M.G.3
  • 28
    • 0142027749 scopus 로고    scopus 로고
    • Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis
    • Taddeo B, Luo TR, Zhang W, Roizman B. Activation of NF-κB in cells productively infected with HSV-1 depends on activated protein kinase R and plays no apparent role in blocking apoptosis. Proc Natl Acad Sci USA 2003; 100: 12408-13.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 12408-12413
    • Taddeo, B.1    Luo, T.R.2    Zhang, W.3    Roizman, B.4
  • 29
    • 25844459154 scopus 로고    scopus 로고
    • Karin M, Greten FR. NF-κB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749-59.
    • Karin M, Greten FR. NF-κB: Linking inflammation and immunity to cancer development and progression. Nat Rev Immunol 2005; 5: 749-59.
  • 30
    • 33744978564 scopus 로고    scopus 로고
    • Karin M. NF-κB and cancer: mechanisms and targets. Mol Carcinog 2006; 45: 355-61.
    • Karin M. NF-κB and cancer: mechanisms and targets. Mol Carcinog 2006; 45: 355-61.
  • 31
    • 33646488626 scopus 로고    scopus 로고
    • NF-κB inhibition: A double-edged sword in cancer?
    • Pikarsky E, Ben-Neriah Y. NF-κB inhibition: a double-edged sword in cancer? Eur J Cancer 2006; 42: 779-84.
    • (2006) Eur J Cancer , vol.42 , pp. 779-784
    • Pikarsky, E.1    Ben-Neriah, Y.2
  • 32
    • 2942675065 scopus 로고    scopus 로고
    • Nuclear factor-κB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer
    • Shishodia S, Aggarwal BB. Nuclear factor-κB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer. Cancer Treat Res 2004; 119: 139-73.
    • (2004) Cancer Treat Res , vol.119 , pp. 139-173
    • Shishodia, S.1    Aggarwal, B.B.2
  • 33
    • 0034741277 scopus 로고    scopus 로고
    • Nuclear factor-κB blockade attenuates but does not abrogate lipopolysaccharide-dependent tumor necrosis factor-α biosynthesis in alveolar epithelial cells
    • Haddad JJ, Land SC. Nuclear factor-κB blockade attenuates but does not abrogate lipopolysaccharide-dependent tumor necrosis factor-α biosynthesis in alveolar epithelial cells. Biochem Biophys Res Commun 2001; 285: 267-72.
    • (2001) Biochem Biophys Res Commun , vol.285 , pp. 267-272
    • Haddad, J.J.1    Land, S.C.2
  • 34
    • 0034647933 scopus 로고    scopus 로고
    • Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells
    • Haddad JJ, Olver RE, Land SC. Antioxidant/pro-oxidant equilibrium regulates HIF-1α and NF-κB redox sensitivity. Evidence for inhibition by glutathione oxidation in alveolar epithelial cells. J Biol Chem 2000; 275: 21130-9.
    • (2000) J Biol Chem , vol.275 , pp. 21130-21139
    • Haddad, J.J.1    Olver, R.E.2    Land, S.C.3
  • 36
    • 2342604896 scopus 로고    scopus 로고
    • + blood monocytes and synovial tissue macrophages in rheumatoid arthritis
    • + blood monocytes and synovial tissue macrophages in rheumatoid arthritis. Arthritis Rheum 2004; 50: 1457-67.
    • (2004) Arthritis Rheum , vol.50 , pp. 1457-1467
    • Iwahashi, M.1    Yamamura, M.2    Aita, T.3
  • 37
    • 1542270907 scopus 로고    scopus 로고
    • Transcription factors in the pathogenesis of autoimmunity
    • Peng SL. Transcription factors in the pathogenesis of autoimmunity. Clin Immunol 2004; 110: 112-23.
    • (2004) Clin Immunol , vol.110 , pp. 112-123
    • Peng, S.L.1
  • 39
    • 0030610362 scopus 로고    scopus 로고
    • A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
    • DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 1997; 388: 548-54.
    • (1997) Nature , vol.388 , pp. 548-554
    • DiDonato, J.A.1    Hayakawa, M.2    Rothwarf, D.M.3    Zandi, E.4    Karin, M.5
  • 40
    • 2342522110 scopus 로고    scopus 로고
    • Shaping the nuclear action of NF-κB
    • Chen LF, Greene WC. Shaping the nuclear action of NF-κB. Nat Rev Mol Cell Biol 2004; 5: 392-401.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 392-401
    • Chen, L.F.1    Greene, W.C.2
  • 41
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang QM. The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Discov 2004; 3: 17-26.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, Q.M.3
  • 42
    • 0442307969 scopus 로고    scopus 로고
    • IκB kinases: Key regulators of the NF-κB pathway
    • Yamamoto Y, Gaynor RB. IκB kinases: key regulators of the NF-κB pathway. Trends Biochem Sci 2004; 29: 72-9.
    • (2004) Trends Biochem Sci , vol.29 , pp. 72-79
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 43
    • 0036151665 scopus 로고    scopus 로고
    • Immunopharmacological potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-κB/ nuclear factor-κB-sensitive pathway in alveolar epithelial cells
    • Haddad JJ, Land SC, Tarnow-Mordi WO, Zembala M, Kowalczyk D, Lauterbach R. Immunopharmacological potential of selective phosphodiesterase inhibition. II. Evidence for the involvement of an inhibitory-κB/ nuclear factor-κB-sensitive pathway in alveolar epithelial cells. J Pharmacol Exp Ther 2002; 300: 567-76.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 567-576
    • Haddad, J.J.1    Land, S.C.2    Tarnow-Mordi, W.O.3    Zembala, M.4    Kowalczyk, D.5    Lauterbach, R.6
  • 44
    • 0030459341 scopus 로고    scopus 로고
    • 2-Mercaptoethanol restores the ability of nuclear factor-κB (NF-κB) to bind DNA in nuclear extracts from interleukin 1 -treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF-κB by PDTC
    • Brennan P, O'Neill LA. 2-Mercaptoethanol restores the ability of nuclear factor-κB (NF-κB) to bind DNA in nuclear extracts from interleukin 1 -treated cells incubated with pyrollidine dithiocarbamate (PDTC). Evidence for oxidation of glutathione in the mechanism of inhibition of NF-κB by PDTC. Biochem J 1996; 320: 975-81.
    • (1996) Biochem J , vol.320 , pp. 975-981
    • Brennan, P.1    O'Neill, L.A.2
  • 45
    • 0032575379 scopus 로고    scopus 로고
    • Direct phosphorylation of IκB by IKKα and IKKβ: Discrimination between free and NF-κB bound substrate
    • Zandi E, Chen Y, Karin M. Direct phosphorylation of IκB by IKKα and IKKβ: discrimination between free and NF-κB bound substrate. Science 1998; 281: 1360-3.
    • (1998) Science , vol.281 , pp. 1360-1363
    • Zandi, E.1    Chen, Y.2    Karin, M.3
  • 46
    • 0036021828 scopus 로고    scopus 로고
    • Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transcription factors in development and pathophysiology
    • Haddad JJ. Oxygen-sensitive pro-inflammatory cytokines, apoptosis signaling and redox-responsive transcription factors in development and pathophysiology. Cytokines Cell Mol Ther 2002; 7: 1-14.
    • (2002) Cytokines Cell Mol Ther , vol.7 , pp. 1-14
    • Haddad, J.J.1
  • 47
    • 4444263810 scopus 로고    scopus 로고
    • Molecular therapeutic targets in inflammation: Cyclooxygenase and NF-κB
    • Krakauer T. Molecular therapeutic targets in inflammation: cyclooxygenase and NF-κB. Curr Drug Targets Inflamm Allergy 2004; 3: 317-24.
    • (2004) Curr Drug Targets Inflamm Allergy , vol.3 , pp. 317-324
    • Krakauer, T.1
  • 48
    • 3042704181 scopus 로고    scopus 로고
    • TRAIL and NF-κB signaling: A complex relationship
    • Wajant H. TRAIL and NF-κB signaling: a complex relationship. Vitam Horm 2004; 67: 101-32.
    • (2004) Vitam Horm , vol.67 , pp. 101-132
    • Wajant, H.1
  • 49
    • 0030220692 scopus 로고    scopus 로고
    • Endotoxin-induced local inflammation and hyperalgesia in rats and mice: A new model for inflammatory pain
    • Kanaan SA, Saadé NE, Haddad JJ, et al. Endotoxin-induced local inflammation and hyperalgesia in rats and mice: a new model for inflammatory pain. Pain 1996; 66: 373-9.
    • (1996) Pain , vol.66 , pp. 373-379
    • Kanaan, S.A.1    Saadé, N.E.2    Haddad, J.J.3
  • 50
    • 10644277789 scopus 로고    scopus 로고
    • The mechanisms by which tissue damage and pain are related
    • Ayrapetyan SN and Apkarian AV Ed
    • Wall PD. The mechanisms by which tissue damage and pain are related. In: Pain Mechanisms and Management, Ayrapetyan SN and Apkarian AV Ed, 1998; 252-9.
    • (1998) Pain Mechanisms and Management , pp. 252-259
    • Wall, P.D.1
  • 51
    • 1642276200 scopus 로고    scopus 로고
    • Dissecting out mechanisms responsible for peripheral neuropathic pain: Implications for diagnosis and therapy
    • Woolf CJ. Dissecting out mechanisms responsible for peripheral neuropathic pain: implications for diagnosis and therapy. Life Sci 2004; 74:2605-10.
    • (2004) Life Sci , vol.74 , pp. 2605-2610
    • Woolf, C.J.1
  • 52
    • 1542268262 scopus 로고    scopus 로고
    • Pain: Moving from symptom control toward mechanism-specific pharmacologic management
    • Woolf CJ. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 2004; 140: 441-51.
    • (2004) Ann Intern Med , vol.140 , pp. 441-451
    • Woolf, C.J.1
  • 53
    • 1842430764 scopus 로고    scopus 로고
    • Afferent pain pathways: A neuroanatomical review
    • Almeida TF, Roizenblatt S, Tufik S. Afferent pain pathways: a neuroanatomical review, Brain Res 2004; 1000: 40-56.
    • (2004) Brain Res , vol.1000 , pp. 40-56
    • Almeida, T.F.1    Roizenblatt, S.2    Tufik, S.3
  • 54
    • 0043135182 scopus 로고    scopus 로고
    • Attenuation of neuropathic manifestations by local block of the activities of the ventro-lateral orbito-frontal area in the rat
    • Baliki M, Al-Amin HA, Atweh SF, et al. Attenuation of neuropathic manifestations by local block of the activities of the ventro-lateral orbito-frontal area in the rat. Neuroscience 2003; 120: 1093-104.
    • (2003) Neuroscience , vol.120 , pp. 1093-1104
    • Baliki, M.1    Al-Amin, H.A.2    Atweh, S.F.3
  • 56
    • 0020621190 scopus 로고
    • Not indifference to pain but varieties of hereditary sensory and autonomic neuropathy
    • Dyck PJ, Mellinger JF, Ragan JJ, et al. Not indifference to pain but varieties of hereditary sensory and autonomic neuropathy. Brain 1983; 106: 373-90.
    • (1983) Brain , vol.106 , pp. 373-390
    • Dyck, P.J.1    Mellinger, J.F.2    Ragan, J.J.3
  • 57
    • 0017929414 scopus 로고
    • Congenital sensory neuropathy with selective loss of small myelinated fibers
    • Loro PA, Burke WJ, Mcleod JG. Congenital sensory neuropathy with selective loss of small myelinated fibers. Ann Neurol 1978; 3: 179-82.
    • (1978) Ann Neurol , vol.3 , pp. 179-182
    • Loro, P.A.1    Burke, W.J.2    Mcleod, J.G.3
  • 58
    • 0000885679 scopus 로고
    • One pain or many pains - A new look at pain mechanisms
    • Cervero F, Laird JMA. One pain or many pains - A new look at pain mechanisms. News Physiologic Sci 1991; 6: 268-73.
    • (1991) News Physiologic Sci , vol.6 , pp. 268-273
    • Cervero, F.1    Laird, J.M.A.2
  • 59
    • 0035855860 scopus 로고    scopus 로고
    • Molecular mechanisms of nociception
    • Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 2001; 413: 203-10.
    • (2001) Nature , vol.413 , pp. 203-210
    • Julius, D.1    Basbaum, A.I.2
  • 60
    • 0027246568 scopus 로고
    • Explosive autotomy induced by simultaneous dorsal column lesion and limb denervation: A possible model for acute deafferentation pain
    • Saadé NE, Ibrahim MZ, Atweh SF, Jabbur SJ. Explosive autotomy induced by simultaneous dorsal column lesion and limb denervation: a possible model for acute deafferentation pain. Exp Neurol 1993; 119: 272-9.
    • (1993) Exp Neurol , vol.119 , pp. 272-279
    • Saadé, N.E.1    Ibrahim, M.Z.2    Atweh, S.F.3    Jabbur, S.J.4
  • 61
    • 0027281204 scopus 로고
    • The role of previous nociceptive input in development of autotomy following cordotomy
    • Saadé NE, Shihabuddin LS, Atweh SF, Jabbur SJ. The role of previous nociceptive input in development of autotomy following cordotomy. Exp Neurol 1993; 119: 280-6.
    • (1993) Exp Neurol , vol.119 , pp. 280-286
    • Saadé, N.E.1    Shihabuddin, L.S.2    Atweh, S.F.3    Jabbur, S.J.4
  • 62
    • 0022430657 scopus 로고
    • Pain and animals
    • Wall PD. Pain and animals. Nature 1985; 316: 672.
    • (1985) Nature , vol.316 , pp. 672
    • Wall, P.D.1
  • 63
    • 0029127526 scopus 로고
    • Inflammatory and neurogenic pain: New molecules, new mechanisms
    • Wall PD. Inflammatory and neurogenic pain: new molecules, new mechanisms. Br J Anaesth 1995; 75: 123-4.
    • (1995) Br J Anaesth , vol.75 , pp. 123-124
    • Wall, P.D.1
  • 64
    • 0030448797 scopus 로고    scopus 로고
    • Plasticity of the nervous system at the systemic, cellular and molecular levels: A mechanism of chronic pain and hyperalgesia
    • Carli G and Zimmermann M Ed, Amsterdam, Elsevier
    • Zimmermann M, Herdegen T. Plasticity of the nervous system at the systemic, cellular and molecular levels: a mechanism of chronic pain and hyperalgesia. In: Progress in brain research. Carli G and Zimmermann M Ed, Amsterdam, Elsevier 1996; 233-59.
    • (1996) Progress in brain research , pp. 233-259
    • Zimmermann, M.1    Herdegen, T.2
  • 65
    • 0029081831 scopus 로고
    • Inflammatory mediators of pain
    • Dray A. Inflammatory mediators of pain. Br J Anaesth 1995; 75: 125-31.
    • (1995) Br J Anaesth , vol.75 , pp. 125-131
    • Dray, A.1
  • 66
    • 0034255106 scopus 로고    scopus 로고
    • Pain control: Breaking the circuit
    • Hunt SP. Pain control: breaking the circuit. Trends Physiologic Sci 2000; 21: 284-7.
    • (2000) Trends Physiologic Sci , vol.21 , pp. 284-287
    • Hunt, S.P.1
  • 67
    • 0035256911 scopus 로고    scopus 로고
    • The molecular dynamics of pain control
    • Hunt SP, Mantyh PW. The molecular dynamics of pain control. Nat Neurosci 2001; 2: 83-91.
    • (2001) Nat Neurosci , vol.2 , pp. 83-91
    • Hunt, S.P.1    Mantyh, P.W.2
  • 68
    • 0034916280 scopus 로고    scopus 로고
    • Molecular basis for the perception of pain
    • Hill RG. Molecular basis for the perception of pain. Neuroscientist 2001; 7: 282-92.
    • (2001) Neuroscientist , vol.7 , pp. 282-292
    • Hill, R.G.1
  • 69
    • 0002914008 scopus 로고    scopus 로고
    • Bradykinin, cytokines and inflammatory hyperalgesia
    • Saadé NE, Apkarian AV and Jabbur SJ Ed, New York, Kluwer Academic/Plenum Publishers
    • Poole S, Cunha FQ, Ferreira SH. Bradykinin, cytokines and inflammatory hyperalgesia. In: Pain and Neuroimmune Interactions. Saadé NE, Apkarian AV and Jabbur SJ Ed, New York, Kluwer Academic/Plenum Publishers 2000; 31-54.
    • (2000) Pain and Neuroimmune Interactions , pp. 31-54
    • Poole, S.1    Cunha, F.Q.2    Ferreira, S.H.3
  • 71
    • 3242687155 scopus 로고    scopus 로고
    • Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats
    • Massaad CA, Safieh-Garabedian B, Poole S, Atweh SF, Jabbur SJ, Saadé NE. Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats. J Neuroimmunol 2004; 153: 171-82.
    • (2004) J Neuroimmunol , vol.153 , pp. 171-182
    • Massaad, C.A.1    Safieh-Garabedian, B.2    Poole, S.3    Atweh, S.F.4    Jabbur, S.J.5    Saadé, N.E.6
  • 72
    • 0026063188 scopus 로고
    • The contribution of the nervous system to inflammation and inflammatory disease
    • Basbaum AI, Levine JD. The contribution of the nervous system to inflammation and inflammatory disease. Can J Physiol Pharmacol 1991; 69: 647-51.
    • (1991) Can J Physiol Pharmacol , vol.69 , pp. 647-651
    • Basbaum, A.I.1    Levine, J.D.2
  • 73
    • 0022980857 scopus 로고
    • Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis
    • Levine JD, Dardick SJ, Roizen MF, Helms C, Basbaum AI. Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis. J Neurosci 1986; 6: 3423-8.
    • (1986) J Neurosci , vol.6 , pp. 3423-3428
    • Levine, J.D.1    Dardick, S.J.2    Roizen, M.F.3    Helms, C.4    Basbaum, A.I.5
  • 75
    • 0036092298 scopus 로고    scopus 로고
    • The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation
    • Safieh-Garabedian B, Poole S, Haddad JJ, Massaad CA, Jabbur SJ, Saadé NE. The role of the sympathetic efferents in endotoxin-induced localized inflammatory hyperalgesia and cytokine upregulation. Neuropharmacology 2002; 42: 864-72.
    • (2002) Neuropharmacology , vol.42 , pp. 864-872
    • Safieh-Garabedian, B.1    Poole, S.2    Haddad, J.J.3    Massaad, C.A.4    Jabbur, S.J.5    Saadé, N.E.6
  • 76
    • 33846070616 scopus 로고    scopus 로고
    • The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
    • Costa B, Trovato AE, Comelli F, Giagnoni G, Colleoni M. The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. Eur J Pharmacol 2007; 556: 75-83.
    • (2007) Eur J Pharmacol , vol.556 , pp. 75-83
    • Costa, B.1    Trovato, A.E.2    Comelli, F.3    Giagnoni, G.4    Colleoni, M.5
  • 77
    • 0001480285 scopus 로고
    • Tasting the inflammatory soup: The role of peripheral neurones
    • Dray A. Tasting the inflammatory soup: The role of peripheral neurones. Pain Rev 1994; 1: 153-71.
    • (1994) Pain Rev , vol.1 , pp. 153-171
    • Dray, A.1
  • 78
    • 0025666348 scopus 로고
    • The changing role of primary afferent neurons in pain
    • McMahon SB, Koltzenburg M. The changing role of primary afferent neurons in pain. Pain 1990; 43: 269-72.
    • (1990) Pain , vol.43 , pp. 269-272
    • McMahon, S.B.1    Koltzenburg, M.2
  • 79
    • 0021268419 scopus 로고
    • Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury
    • McMahon SB, Wall PD. Receptive fields of rat lamina 1 projection cells move to incorporate a nearby region of injury. Pain 1984; 19: 235-48.
    • (1984) Pain , vol.19 , pp. 235-248
    • McMahon, S.B.1    Wall, P.D.2
  • 80
    • 0027477465 scopus 로고
    • Contribution of central neuroplasticity to pathological pain: Review of clinical and experimental evidence
    • Coderre TJ, Kats J, Vaccarino A, Melzack R. Contribution of central neuroplasticity to pathological pain: review of clinical and experimental evidence. Pain 1993; 52: 259-85.
    • (1993) Pain , vol.52 , pp. 259-285
    • Coderre, T.J.1    Kats, J.2    Vaccarino, A.3    Melzack, R.4
  • 81
    • 0026621804 scopus 로고
    • Painful neuropathy: Altered central processing maintained dynamically by peripheral input
    • Gracely RH, Lynch SA, Bennett GJ. Painful neuropathy: altered central processing maintained dynamically by peripheral input. Pain 1992; 51: 175-94.
    • (1992) Pain , vol.51 , pp. 175-194
    • Gracely, R.H.1    Lynch, S.A.2    Bennett, G.J.3
  • 82
    • 0032723079 scopus 로고    scopus 로고
    • Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain
    • Dib-Hajj SD, Fjell J, Cummins TR, et al. Plasticity of sodium channel expression in DRG neurons in the chronic constriction injury model of neuropathic pain. Pain 1999; 83: 591-600.
    • (1999) Pain , vol.83 , pp. 591-600
    • Dib-Hajj, S.D.1    Fjell, J.2    Cummins, T.R.3
  • 83
    • 0025662039 scopus 로고
    • Cross-excitation in dorsal root ganglia of nerve - injured and intact rats
    • Devor M, Wall PD. Cross-excitation in dorsal root ganglia of nerve - injured and intact rats. J Neurophysiol 1990; 64: 1733-46.
    • (1990) J Neurophysiol , vol.64 , pp. 1733-1746
    • Devor, M.1    Wall, P.D.2
  • 84
    • 0001937431 scopus 로고    scopus 로고
    • Pathophysiology of damaged nerve in relation to chronic pain
    • Wall PD and Melzack R Ed, New York, Churchil Livingston
    • Devor M, Seltzer Z. Pathophysiology of damaged nerve in relation to chronic pain. In: Textbook of Pain. Wall PD and Melzack R Ed, New York, Churchil Livingston 1999; 129-64.
    • (1999) Textbook of Pain , pp. 129-164
    • Devor, M.1    Seltzer, Z.2
  • 85
    • 33749341230 scopus 로고    scopus 로고
    • AM404, an inhibitor of anandamide uptake, prevents pain behavior and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain
    • Costa B, Siniscalco D, Trovato AE, et al. AM404, an inhibitor of anandamide uptake, prevents pain behavior and modulates cytokine and apoptotic pathways in a rat model of neuropathic pain. Br J Pharmacol 2006; 148: 1022-32.
    • (2006) Br J Pharmacol , vol.148 , pp. 1022-1032
    • Costa, B.1    Siniscalco, D.2    Trovato, A.E.3
  • 87
    • 0033529298 scopus 로고    scopus 로고
    • Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies?
    • Bennett GJ. Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies? Proc Natl Acad Sci USA 1999; 96: 7737-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7737-7738
    • Bennett, G.J.1
  • 88
    • 0035215306 scopus 로고    scopus 로고
    • A new model of sciatic inflammatory neuritis (SIN): Induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats
    • Chacur M, Milligan ED, Gazda LS, et al. A new model of sciatic inflammatory neuritis (SIN): induction of unilateral and bilateral mechanical allodynia following acute unilateral peri-sciatic immune activation in rats. Pain 2001; 94: 231-44.
    • (2001) Pain , vol.94 , pp. 231-244
    • Chacur, M.1    Milligan, E.D.2    Gazda, L.S.3
  • 89
    • 0029783630 scopus 로고    scopus 로고
    • Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model
    • DeLeo JA, Colburn RW, Nichols ML, Malhotra A. Interleukin-6-mediated hyperalgesia/allodynia and increased spinal IL-6 expression in a rat mononeuropathy model. J Interferon Cytokine Res 1996; 16: 695-700.
    • (1996) J Interferon Cytokine Res , vol.16 , pp. 695-700
    • DeLeo, J.A.1    Colburn, R.W.2    Nichols, M.L.3    Malhotra, A.4
  • 90
    • 0003731855 scopus 로고    scopus 로고
    • Cytokines and neuropathic pain
    • Hansson PT, Fields HL, Hill RG and Marchettini P Ed, Seattle, IASP Press
    • Sommer C. Cytokines and neuropathic pain. In: Neuropathic Pain: Pathophysiology and Treatment, Hansson PT, Fields HL, Hill RG and Marchettini P Ed, Seattle, IASP Press 2001; 37-62.
    • (2001) Neuropathic Pain: Pathophysiology and Treatment , pp. 37-62
    • Sommer, C.1
  • 91
    • 0142105847 scopus 로고    scopus 로고
    • Painful neuropathies
    • Sommer C. Painful neuropathies. Curr Opin Neurol 2003 ; 16 : 623-8.
    • (2003) Curr Opin Neurol , vol.16 , pp. 623-628
    • Sommer, C.1
  • 92
    • 0021861214 scopus 로고
    • Inhibition of nociceptive evoked activity in spinal neurons through a dorsal column-brainstem-spinal loop
    • Saadé NE, Tabet MS, Banna NR, Atweh SF, Jabbur SJ. Inhibition of nociceptive evoked activity in spinal neurons through a dorsal column-brainstem-spinal loop. Brain Res 1985; 339: 115-8.
    • (1985) Brain Res , vol.339 , pp. 115-118
    • Saadé, N.E.1    Tabet, M.S.2    Banna, N.R.3    Atweh, S.F.4    Jabbur, S.J.5
  • 93
    • 0025125385 scopus 로고
    • Effects of lesions in the anterolateral columns and dorsolateral funiculi on self-mutilation behavior in rats
    • Saadé NE, Atweh SF, Jabbur SJ, Wall PD. Effects of lesions in the anterolateral columns and dorsolateral funiculi on self-mutilation behavior in rats. Pain 1990; 42: 313-21.
    • (1990) Pain , vol.42 , pp. 313-321
    • Saadé, N.E.1    Atweh, S.F.2    Jabbur, S.J.3    Wall, P.D.4
  • 94
    • 0030754851 scopus 로고    scopus 로고
    • Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice
    • Kanaan SA, Safieh-Garabedian B, Haddad JJ, et al. Effects of various analgesic and anti-inflammatory drugs on endotoxin-induced hyperalgesia in rats and mice. Pharmacology 1997; 54: 285-97.
    • (1997) Pharmacology , vol.54 , pp. 285-297
    • Kanaan, S.A.1    Safieh-Garabedian, B.2    Haddad, J.J.3
  • 95
    • 0033176472 scopus 로고    scopus 로고
    • From electrical wiring to plastic neurons: Evolving approaches to the study of pain
    • Jabbur SJ, Saadé NE. From electrical wiring to plastic neurons: evolving approaches to the study of pain. Pain 1999; 6: S87-92.
    • (1999) Pain , vol.6
    • Jabbur, S.J.1    Saadé, N.E.2
  • 96
    • 0031000857 scopus 로고    scopus 로고
    • Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons
    • Saadé NE, Atweh SF, Bahuth NB, Jabbur SJ. Augmentation of nociceptive reflexes and chronic deafferentation pain by chemical lesions of either dopaminergic terminals or midbrain dopaminergic neurons. Brain Res 1997; 751: 1-12.
    • (1997) Brain Res , vol.751 , pp. 1-12
    • Saadé, N.E.1    Atweh, S.F.2    Bahuth, N.B.3    Jabbur, S.J.4
  • 100
    • 3042714222 scopus 로고    scopus 로고
    • Spinal NF-κB activation induces COX-2 upregulation and contributes to inflammatory pain hyper-sensitivity
    • Lee KM, Kang BS, Lee HL, et al. Spinal NF-κB activation induces COX-2 upregulation and contributes to inflammatory pain hyper-sensitivity. Eur J Neurosci 2004; 19: 3375-81.
    • (2004) Eur J Neurosci , vol.19 , pp. 3375-3381
    • Lee, K.M.1    Kang, B.S.2    Lee, H.L.3
  • 101
    • 33846025430 scopus 로고    scopus 로고
    • Persistent activation of nuclear factor κ-B signaling pathway in patients with unstable angina and elevated levels of C-reactive protein evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive protein on human monocytes via nuclear factor κ-B activation
    • Liuzzo G, Santamaria M, Biasucci LM, et al. Persistent activation of nuclear factor κ-B signaling pathway in patients with unstable angina and elevated levels of C-reactive protein evidence for a direct proinflammatory effect of azide and lipopolysaccharide-free C-reactive protein on human monocytes via nuclear factor κ-B activation. J Am Coll Cardiol 2007; 49: 185-94.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 185-194
    • Liuzzo, G.1    Santamaria, M.2    Biasucci, L.M.3
  • 102
    • 11144249792 scopus 로고    scopus 로고
    • Physiological functions for brain NF-κB
    • Meffert MK, Baltimore D. Physiological functions for brain NF-κB. Trends Neurosci 2005; 28: 37-43.
    • (2005) Trends Neurosci , vol.28 , pp. 37-43
    • Meffert, M.K.1    Baltimore, D.2
  • 103
    • 0032724994 scopus 로고    scopus 로고
    • Inhibition of peripheral NF-κB activation by central action of α-melanocyte-stimulating hormone
    • Ichiyama T, Sakai T, Catania A, Barsh GS, Furukawa S, Lipton JM. Inhibition of peripheral NF-κB activation by central action of α-melanocyte-stimulating hormone. J Neuroimmunol 1999; 99: 211-7.
    • (1999) J Neuroimmunol , vol.99 , pp. 211-217
    • Ichiyama, T.1    Sakai, T.2    Catania, A.3    Barsh, G.S.4    Furukawa, S.5    Lipton, J.M.6
  • 104
    • 23044514629 scopus 로고    scopus 로고
    • NF-κB activates in vivo the synthesis of inducible Cox-2 in the brain
    • Nadjar A, Tridon V, May MJ, et al. NF-κB activates in vivo the synthesis of inducible Cox-2 in the brain. J Cereb Blood Flow Metab 2005; 25: 1047-59.
    • (2005) J Cereb Blood Flow Metab , vol.25 , pp. 1047-1059
    • Nadjar, A.1    Tridon, V.2    May, M.J.3
  • 105
    • 0028988514 scopus 로고
    • Regulation of NF-κB activity in rat dorsal root ganglia and PC12 cells by tumor necrosis factor and nerve growth factor
    • Wood JN. Regulation of NF-κB activity in rat dorsal root ganglia and PC12 cells by tumor necrosis factor and nerve growth factor. Neurosci Lett 1995; 192: 41-4.
    • (1995) Neurosci Lett , vol.192 , pp. 41-44
    • Wood, J.N.1
  • 106
    • 0032578025 scopus 로고    scopus 로고
    • Increased activation of nuclear factor-κB in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries
    • Ma W, Bisby MA. Increased activation of nuclear factor-κB in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res 1998; 797: 243-54.
    • (1998) Brain Res , vol.797 , pp. 243-254
    • Ma, W.1    Bisby, M.A.2
  • 107
    • 20044381692 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB via endogenous tumor necrosis factor alpha regulates survival of axotomized adult sensory neurons
    • Fernyhough P, Smith DR, Schapansky J, et al. Activation of nuclear factor-κB via endogenous tumor necrosis factor alpha regulates survival of axotomized adult sensory neurons. J Neurosci 2005; 25: 1682-90.
    • (2005) J Neurosci , vol.25 , pp. 1682-1690
    • Fernyhough, P.1    Smith, D.R.2    Schapansky, J.3
  • 108
    • 18844368236 scopus 로고    scopus 로고
    • Modulation of peripheral inflammation in sensory ganglia by nuclear factor κB decoy oligodeoxynucleotide: Involvement of SRC kinase pathway
    • Igwe OJ. Modulation of peripheral inflammation in sensory ganglia by nuclear factor κB decoy oligodeoxynucleotide: involvement of SRC kinase pathway. Neurosci Lett 2005; 381: 114-9.
    • (2005) Neurosci Lett , vol.381 , pp. 114-119
    • Igwe, O.J.1
  • 109
    • 7944227871 scopus 로고    scopus 로고
    • Inhibition of the nuclear factor-κB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats
    • La Rosa G, Cardali S, Genovese T, et al. Inhibition of the nuclear factor-κB activation with pyrrolidine dithiocarbamate attenuating inflammation and oxidative stress after experimental spinal cord trauma in rats. J Neurosurg Spine 2004; 1: 311-21.
    • (2004) J Neurosurg Spine , vol.1 , pp. 311-321
    • La Rosa, G.1    Cardali, S.2    Genovese, T.3
  • 110
    • 9744246881 scopus 로고    scopus 로고
    • Manganese superoxide dismutase induced by TNF-β is regulated transcriptionally by NF-κB after spinal cord injury in rats
    • Yune TY, Lee SM, Kim SJ, et al. Manganese superoxide dismutase induced by TNF-β is regulated transcriptionally by NF-κB after spinal cord injury in rats. J Neurotrauma 2004; 21: 1778-94.
    • (2004) J Neurotrauma , vol.21 , pp. 1778-1794
    • Yune, T.Y.1    Lee, S.M.2    Kim, S.J.3
  • 111
    • 22344431751 scopus 로고    scopus 로고
    • Inhibition of astroglial nuclear factor-κB reduces inflammation and improves functional recovery after spinal cord injury
    • Brambilla R, Bracchi-Ricard V, Hu WH, et al. Inhibition of astroglial nuclear factor-κB reduces inflammation and improves functional recovery after spinal cord injury. J Exp Med 2005; 202: 145-56.
    • (2005) J Exp Med , vol.202 , pp. 145-156
    • Brambilla, R.1    Bracchi-Ricard, V.2    Hu, W.H.3
  • 112
    • 27644498849 scopus 로고    scopus 로고
    • Involvement of spinal cord nuclear factor-κB activation in rat models of proinflammatory cytokine-mediated pain facilitation
    • Ledeboer A, Gamanos M, Lai W, et al. Involvement of spinal cord nuclear factor-κB activation in rat models of proinflammatory cytokine-mediated pain facilitation. Eur J Neurosci 2005; 22: 1977-86.
    • (2005) Eur J Neurosci , vol.22 , pp. 1977-1986
    • Ledeboer, A.1    Gamanos, M.2    Lai, W.3
  • 113
    • 4944256956 scopus 로고    scopus 로고
    • γ-Mangostin inhibits inhibitor-κB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells
    • Nakatani K, Yamakuni T, Kondo N, et al. γ-Mangostin inhibits inhibitor-κB kinase activity and decreases lipopolysaccharide-induced cyclooxygenase-2 gene expression in C6 rat glioma cells. Mol Pharmacol 2004; 66: 667-74.
    • (2004) Mol Pharmacol , vol.66 , pp. 667-674
    • Nakatani, K.1    Yamakuni, T.2    Kondo, N.3
  • 114
    • 0030976878 scopus 로고    scopus 로고
    • Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor-κB) activation: Role of arachidonic acid
    • Mitchell JA, Saunders M, Barnes PJ, Newton R, Belvisi MG. Sodium salicylate inhibits cyclo-oxygenase-2 activity independently of transcription factor (nuclear factor-κB) activation: role of arachidonic acid. Mol Pharmacol 1997; 51: 907-12.
    • (1997) Mol Pharmacol , vol.51 , pp. 907-912
    • Mitchell, J.A.1    Saunders, M.2    Barnes, P.J.3    Newton, R.4    Belvisi, M.G.5
  • 115
    • 0032487857 scopus 로고    scopus 로고
    • The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β
    • Yin MJ, Yamamoto Y, Gaynor RB. The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β. Nature 1998; 396: 77-80.
    • (1998) Nature , vol.396 , pp. 77-80
    • Yin, M.J.1    Yamamoto, Y.2    Gaynor, R.B.3
  • 116
    • 0142165030 scopus 로고    scopus 로고
    • The mechanism of action of aspirin
    • Vane JR, Botting RM. The mechanism of action of aspirin. Thromb Res 2003; 110: 255-8.
    • (2003) Thromb Res , vol.110 , pp. 255-258
    • Vane, J.R.1    Botting, R.M.2
  • 118
    • 0041974556 scopus 로고    scopus 로고
    • Aspirin and other cyclooxygenase inhibitors: New therapeutic insights
    • Wu KK. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med 2003; 3: 107-12.
    • (2003) Semin Vasc Med , vol.3 , pp. 107-112
    • Wu, K.K.1
  • 119
    • 0022527952 scopus 로고
    • Prostaglandins, pain, and inflammation
    • Ferreira SH. Prostaglandins, pain, and inflammation. Agents Actions Suppl 1986; 19: 91-8.
    • (1986) Agents Actions Suppl , vol.19 , pp. 91-98
    • Ferreira, S.H.1
  • 120
    • 1642398098 scopus 로고    scopus 로고
    • Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury
    • Ma W, Eisenach JC. Cyclooxygenase 2 in infiltrating inflammatory cells in injured nerve is universally up-regulated following various types of peripheral nerve injury. Neuroscience 2003; 121: 691-704.
    • (2003) Neuroscience , vol.121 , pp. 691-704
    • Ma, W.1    Eisenach, J.C.2
  • 121
    • 0033623371 scopus 로고    scopus 로고
    • 2 synthesis in human neuroblastoma cells: Involvement of p38 mitogen-activated protein kinase and nuclear factor-κB
    • 2 synthesis in human neuroblastoma cells: involvement of p38 mitogen-activated protein kinase and nuclear factor-κB. J Neurochem 2000; 75: 2020-8.
    • (2000) J Neurochem , vol.75 , pp. 2020-2028
    • Fiebich, B.L.1    Mueksch, B.2    Boehringer, M.3    Hull, M.4
  • 122
    • 0037304062 scopus 로고    scopus 로고
    • Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis
    • Johnson-Pais TL, Singer FR, Bone HG, McMurray CT, Hansen MF, Leach RJ. Identification of a novel tandem duplication in exon 1 of the TNFRSF11A gene in two unrelated patients with familial expansile osteolysis. J Bone Miner Res 2003; 18: 376-80.
    • (2003) J Bone Miner Res , vol.18 , pp. 376-380
    • Johnson-Pais, T.L.1    Singer, F.R.2    Bone, H.G.3    McMurray, C.T.4    Hansen, M.F.5    Leach, R.J.6
  • 123
    • 0034045349 scopus 로고    scopus 로고
    • Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NF-κB and AP-1
    • Valen G, Hansson GK, Dumitrescu A, Vaage J. Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NF-κB and AP-1. Cardiovasc Res 2000; 47: 49-56.
    • (2000) Cardiovasc Res , vol.47 , pp. 49-56
    • Valen, G.1    Hansson, G.K.2    Dumitrescu, A.3    Vaage, J.4
  • 126
    • 1342342982 scopus 로고    scopus 로고
    • The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans
    • Koppert W, Wehrfritz A, Korber N, et al. The cyclooxygenase isozyme inhibitors parecoxib and paracetamol reduce central hyperalgesia in humans. Pain 2004; 108: 148-53.
    • (2004) Pain , vol.108 , pp. 148-153
    • Koppert, W.1    Wehrfritz, A.2    Korber, N.3
  • 129
    • 0042467554 scopus 로고    scopus 로고
    • Loss of the cylindromatosis tumor suppressor inhibits apoptosis by activating NF-κB
    • Brummelkamp TR, Nijman SM, Dirac AM, Bernards R. Loss of the cylindromatosis tumor suppressor inhibits apoptosis by activating NF-κB. Nature 2003; 424: 797-801
    • (2003) Nature , vol.424 , pp. 797-801
    • Brummelkamp, T.R.1    Nijman, S.M.2    Dirac, A.M.3    Bernards, R.4
  • 130
    • 33745025242 scopus 로고    scopus 로고
    • An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis
    • Oosterkamp HM, Neering H, Nijman SM, et al. An evaluation of the efficacy of topical application of salicylic acid for the treatment of familial cylindromatosis. Br J Dermatol 2006; 155: 182-5.
    • (2006) Br J Dermatol , vol.155 , pp. 182-185
    • Oosterkamp, H.M.1    Neering, H.2    Nijman, S.M.3
  • 131
    • 2342646193 scopus 로고    scopus 로고
    • Recent findings on how proinflammatory cytokines cause pain: Peripheral mechanisms in inflammatory and neuropathic hyperalgesia
    • Sommer C, Kress M. Recent findings on how proinflammatory cytokines cause pain: Peripheral mechanisms in inflammatory and neuropathic hyperalgesia. Neurosci Lett 2004; 361: 184-7.
    • (2004) Neurosci Lett , vol.361 , pp. 184-187
    • Sommer, C.1    Kress, M.2
  • 132
    • 1642579573 scopus 로고    scopus 로고
    • Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia
    • DeLeo JA, Tanga FY, Tawfik VL. Neuroimmune activation and neuroinflammation in chronic pain and opioid tolerance/hyperalgesia. Neuroscientist 1996; 10: 40-52.
    • (1996) Neuroscientist , vol.10 , pp. 40-52
    • DeLeo, J.A.1    Tanga, F.Y.2    Tawfik, V.L.3
  • 134
    • 0034068667 scopus 로고    scopus 로고
    • Pain at the cellular level: The role of the cytokine tumor necrosis factor-α
    • Friedman R. Pain at the cellular level: the role of the cytokine tumor necrosis factor-α. Reg Anesth Pain Med 2000; 25: 110-2.
    • (2000) Reg Anesth Pain Med , vol.25 , pp. 110-112
    • Friedman, R.1
  • 135
    • 0032573018 scopus 로고    scopus 로고
    • Nuclear factor-κB is selectively and markedly activated in humans with unstable angina pectoris
    • Ritchie ME. Nuclear factor-κB is selectively and markedly activated in humans with unstable angina pectoris. Circulation 1998; 98: 1707-13.
    • (1998) Circulation , vol.98 , pp. 1707-1713
    • Ritchie, M.E.1
  • 136
    • 85046520485 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB in unstable angina
    • Jenkins N. Activation of nuclear factor-κB in unstable angina. Circulation 1999; 100: 1462-3.
    • (1999) Circulation , vol.100 , pp. 1462-1463
    • Jenkins, N.1
  • 137
    • 0036158178 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo
    • Smith RS, Harris SG, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol 2002; 184: 1132-9.
    • (2002) J Bacteriol , vol.184 , pp. 1132-1139
    • Smith, R.S.1    Harris, S.G.2    Phipps, R.3    Iglewski, B.4
  • 138
    • 21844437380 scopus 로고    scopus 로고
    • Intraneural injection of interleukin-1β and tumor necrosis factor-α into rat sciatic nerve at physiological doses induces signs of neuropathic pain
    • Zelenka M, Schafers M, Sommer C. Intraneural injection of interleukin-1β and tumor necrosis factor-α into rat sciatic nerve at physiological doses induces signs of neuropathic pain. Pain 2005; 116: 257-63.
    • (2005) Pain , vol.116 , pp. 257-263
    • Zelenka, M.1    Schafers, M.2    Sommer, C.3
  • 139
    • 0033830249 scopus 로고    scopus 로고
    • Identifying pain genes: Bottom-up and top-down approaches
    • Mogil JS, McCarson KE. Identifying pain genes: bottom-up and top-down approaches. J Pain 2000; 1: 66-80.
    • (2000) J Pain , vol.1 , pp. 66-80
    • Mogil, J.S.1    McCarson, K.E.2
  • 140
    • 0031577796 scopus 로고    scopus 로고
    • Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R)
    • Lorimer DD, Matkowskj K, Benya RV. Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). Biochem Biophys Res Commun 1997; 241: 558-64.
    • (1997) Biochem Biophys Res Commun , vol.241 , pp. 558-564
    • Lorimer, D.D.1    Matkowskj, K.2    Benya, R.V.3
  • 141
    • 0030726331 scopus 로고    scopus 로고
    • Kinins and their receptors in hyperalgesia
    • Dray A. Kinins and their receptors in hyperalgesia. Can J Physiol Pharmacol 1997; 75: 704-12.
    • (1997) Can J Physiol Pharmacol , vol.75 , pp. 704-712
    • Dray, A.1
  • 142
    • 10844228161 scopus 로고    scopus 로고
    • Kinin B1 receptors: Key G-protein-coupled receptors and their role in inflammatory and painful processes
    • Calixto JB, Medeiros R, Fernandes ES, Ferreira J, Cabrini DA, Campos MM. Kinin B1 receptors: key G-protein-coupled receptors and their role in inflammatory and painful processes. Br J Pharmacol 2004; 143: 803-18.
    • (2004) Br J Pharmacol , vol.143 , pp. 803-818
    • Calixto, J.B.1    Medeiros, R.2    Fernandes, E.S.3    Ferreira, J.4    Cabrini, D.A.5    Campos, M.M.6
  • 143
    • 6444236841 scopus 로고    scopus 로고
    • Bradykinin receptor ligands: Therapeutic perspectives
    • Marceau F, Regoli D. Bradykinin receptor ligands: therapeutic perspectives. Nat Rev Drug Discov 2004; 3: 845-52.
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 845-852
    • Marceau, F.1    Regoli, D.2
  • 144
    • 0142031478 scopus 로고    scopus 로고
    • Roles for the kallikrein-kinin system in inflammatory exudation and pain: Lessons from studies on kininogen-deficient rats
    • Ueno A, Oh-ishi S. Roles for the kallikrein-kinin system in inflammatory exudation and pain: lessons from studies on kininogen-deficient rats. J Pharmacol Sci 2003; 93: 1-20.
    • (2003) J Pharmacol Sci , vol.93 , pp. 1-20
    • Ueno, A.1    Oh-ishi, S.2
  • 146
    • 0034102212 scopus 로고    scopus 로고
    • 2-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis
    • 2-evoked regulation of HIF-1α and NF-κB in perinatal lung epithelium requires glutathione biosynthesis. Am J Physiol Lung Cell Mol Physiol. 2000; 278: L492-503.
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278
    • Haddad, J.J.1    Land, S.C.2
  • 147
    • 0034683198 scopus 로고    scopus 로고
    • Activation of transcription factors of nuclear factor-κB, activator protein-1 and octamer factors in hyperalgesia
    • Chan CF, Sun WZ, Lin JK, Lin-Shiau SY. Activation of transcription factors of nuclear factor-κB, activator protein-1 and octamer factors in hyperalgesia. Eur J Pharmacol 2000; 402: 61-8.
    • (2000) Eur J Pharmacol , vol.402 , pp. 61-68
    • Chan, C.F.1    Sun, W.Z.2    Lin, J.K.3    Lin-Shiau, S.Y.4
  • 148
    • 33845353520 scopus 로고    scopus 로고
    • Injection of nuclear factor-κB decoy into the sciatic nerve suppresses mechanical allodynia and thermal hyperalgesia in a rat inflammatory pain model
    • Inoue G, Ochiai N, Ohtori S, et al. Injection of nuclear factor-κB decoy into the sciatic nerve suppresses mechanical allodynia and thermal hyperalgesia in a rat inflammatory pain model. Spine 2006; 31: 2904-8.
    • (2006) Spine , vol.31 , pp. 2904-2908
    • Inoue, G.1    Ochiai, N.2    Ohtori, S.3
  • 149
    • 33748847898 scopus 로고    scopus 로고
    • Alleviation of neuropathic pain by intrathecal injection of antisense oligonucleotides to p65 subunit of NF-κB
    • Sun T, Song WG, Fu ZJ, Liu ZH, Liu YM, Yao SL. Alleviation of neuropathic pain by intrathecal injection of antisense oligonucleotides to p65 subunit of NF-κB. Br J Anaesth 2006; 97: 553-8.
    • (2006) Br J Anaesth , vol.97 , pp. 553-558
    • Sun, T.1    Song, W.G.2    Fu, Z.J.3    Liu, Z.H.4    Liu, Y.M.5    Yao, S.L.6
  • 150
    • 0035919810 scopus 로고    scopus 로고
    • NF-κB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model
    • Sakaue G, Shimaoka M, Fukuoka T, et al. NF-κB decoy suppresses cytokine expression and thermal hyperalgesia in a rat neuropathic pain model. Neuroreport 2001; 12: 2079-84.
    • (2001) Neuroreport , vol.12 , pp. 2079-2084
    • Sakaue, G.1    Shimaoka, M.2    Fukuoka, T.3
  • 151
    • 1642545592 scopus 로고    scopus 로고
    • Initial clinical cases of the use of a NF-κB decoy at the site of coronary stenting for the prevention of restenosis
    • Jun-Ichi S, Hiroshi I, Ryo G, Ryuichi M, Kensuke E, Mitsuaki I. Initial clinical cases of the use of a NF-κB decoy at the site of coronary stenting for the prevention of restenosis. Circ J 2004; 68: 270-1.
    • (2004) Circ J , vol.68 , pp. 270-271
    • Jun-Ichi, S.1    Hiroshi, I.2    Ryo, G.3    Ryuichi, M.4    Kensuke, E.5    Mitsuaki, I.6
  • 153
    • 0032541657 scopus 로고    scopus 로고
    • IKK-γ is an essential regulatory subunit of the IκB kinase complex
    • Rothwarf DM, Zandi E, Natoli G, Karin M. IKK-γ is an essential regulatory subunit of the IκB kinase complex. Nature 1998; 395: 297-300.
    • (1998) Nature , vol.395 , pp. 297-300
    • Rothwarf, D.M.1    Zandi, E.2    Natoli, G.3    Karin, M.4
  • 154
    • 23744498932 scopus 로고    scopus 로고
    • Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury
    • Yu CG, Yezierski RP. Activation of the ERK1/2 signaling cascade by excitotoxic spinal cord injury. Brain Res Mol Brain Res 2005; 138: 244-55.
    • (2005) Brain Res Mol Brain Res , vol.138 , pp. 244-255
    • Yu, C.G.1    Yezierski, R.P.2
  • 155
    • 33846874140 scopus 로고    scopus 로고
    • Tumor necrosis factor-α induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: The role of NF-κB, JNK and p38 MAPK
    • Liu YL, Zhou LJ, Hu NW, et al. Tumor necrosis factor-α induces long-term potentiation of C-fiber evoked field potentials in spinal dorsal horn in rats with nerve injury: The role of NF-κB, JNK and p38 MAPK. Neuropharmacology 2007; 52: 708-15.
    • (2007) Neuropharmacology , vol.52 , pp. 708-715
    • Liu, Y.L.1    Zhou, L.J.2    Hu, N.W.3
  • 156
    • 0037154658 scopus 로고    scopus 로고
    • Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-κB1 knockout mice
    • Park HJ, Lee HS, Lee HJ, et al. Decrease of the electroacupuncture-induced analgesic effects in nuclear factor-κB1 knockout mice. Neurosci Lett 2002; 319: 141-4.
    • (2002) Neurosci Lett , vol.319 , pp. 141-144
    • Park, H.J.1    Lee, H.S.2    Lee, H.J.3
  • 157
    • 0036203038 scopus 로고    scopus 로고
    • Involvement of activator protein-1 in transcriptional regulation of the human μ-opioid receptor gene
    • Borner C, Hollt V, Kraus J. Involvement of activator protein-1 in transcriptional regulation of the human μ-opioid receptor gene. Mol Pharmacol 2002; 61: 800-5.
    • (2002) Mol Pharmacol , vol.61 , pp. 800-805
    • Borner, C.1    Hollt, V.2    Kraus, J.3
  • 158
    • 0141680731 scopus 로고    scopus 로고
    • The role of NF-κB in tumor necrosis factor-regulated transcription of the human μ-opioid receptor gene
    • Kraus J, Borner C, Giannini E, Hollt V. The role of NF-κB in tumor necrosis factor-regulated transcription of the human μ-opioid receptor gene. Mol Pharmacol 2003; 64: 876-84.
    • (2003) Mol Pharmacol , vol.64 , pp. 876-884
    • Kraus, J.1    Borner, C.2    Giannini, E.3    Hollt, V.4
  • 159
    • 33845317629 scopus 로고    scopus 로고
    • Action of NF-κB on the delta opioid receptor gene promoter
    • Chen YL, Law PY, Loh HH. Action of NF-κB on the delta opioid receptor gene promoter. Biochem Biophys Res Commun 2007; 352: 818-22.
    • (2007) Biochem Biophys Res Commun , vol.352 , pp. 818-822
    • Chen, Y.L.1    Law, P.Y.2    Loh, H.H.3
  • 160
    • 85047694774 scopus 로고    scopus 로고
    • Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily
    • Bierhaus A, Haslbeck KM, Humpert PM, et al. Loss of pain perception in diabetes is dependent on a receptor of the immunoglobulin superfamily. J Clin Invest 2004; 114: 1741-51.
    • (2004) J Clin Invest , vol.114 , pp. 1741-1751
    • Bierhaus, A.1    Haslbeck, K.M.2    Humpert, P.M.3
  • 161
    • 17644381896 scopus 로고    scopus 로고
    • In vitro and in vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis
    • Kim IT, Park HJ, Nam JH, et al. In vitro and in vivo anti-inflammatory and antinociceptive effects of the methanol extract of the roots of Morinda officinalis. J Pharm Pharmacol 2005; 57: 607-15.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 607-615
    • Kim, I.T.1    Park, H.J.2    Nam, J.H.3
  • 162
    • 30544441256 scopus 로고    scopus 로고
    • Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats
    • Wang S, Lim G, Yang L, Sung B, Mao J. Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats. Pain 2006; 120: 78-85.
    • (2006) Pain , vol.120 , pp. 78-85
    • Wang, S.1    Lim, G.2    Yang, L.3    Sung, B.4    Mao, J.5
  • 163
    • 0344012614 scopus 로고    scopus 로고
    • Putting the brake on inflammatory responses: The role of glucocorticoids
    • Hermoso MA, Cidlowski JA. Putting the brake on inflammatory responses: the role of glucocorticoids. IUBMB Life 2003; 55: 497-504.
    • (2003) IUBMB Life , vol.55 , pp. 497-504
    • Hermoso, M.A.1    Cidlowski, J.A.2
  • 164
    • 33646147800 scopus 로고    scopus 로고
    • Reciprocal regulation of nuclear factor κB and its inhibitor ZAS3 after peripheral nerve injury
    • Wu LC, Goettl VM, Madiai F, Hackshaw KV, Hussain SR. Reciprocal regulation of nuclear factor κB and its inhibitor ZAS3 after peripheral nerve injury. BMC Neurosci 2006; 7: 4.
    • (2006) BMC Neurosci , vol.7 , pp. 4
    • Wu, L.C.1    Goettl, V.M.2    Madiai, F.3    Hackshaw, K.V.4    Hussain, S.R.5
  • 165
    • 33744501872 scopus 로고    scopus 로고
    • Betamethasone affects cerebral expressions of NF-κB and cytokines that correlate with pain behavior in a rat model of neuropathy
    • Xie W, Luo S, Xuan H, et al. Betamethasone affects cerebral expressions of NF-κB and cytokines that correlate with pain behavior in a rat model of neuropathy. Ann Clin Lab Sci 2006; 36: 39-46.
    • (2006) Ann Clin Lab Sci , vol.36 , pp. 39-46
    • Xie, W.1    Luo, S.2    Xuan, H.3
  • 166
    • 25644451962 scopus 로고    scopus 로고
    • Morphine induces late cardioprotection in rat hearts in vivo: The involvement of opioid receptors and nuclear transcription factor κB
    • Frassdorf J, Weber NC, Obal D, et al. Morphine induces late cardioprotection in rat hearts in vivo: the involvement of opioid receptors and nuclear transcription factor κB. Anesth Analg 2005; 101: 934-41.
    • (2005) Anesth Analg , vol.101 , pp. 934-941
    • Frassdorf, J.1    Weber, N.C.2    Obal, D.3
  • 167
    • 0036029247 scopus 로고    scopus 로고
    • Cytokines and related receptor-mediated signaling pathways
    • Haddad JJ. Cytokines and related receptor-mediated signaling pathways. Biochem Biophys Res Commun 2002; 297: 700-13.
    • (2002) Biochem Biophys Res Commun , vol.297 , pp. 700-713
    • Haddad, J.J.1
  • 168
    • 4143073273 scopus 로고    scopus 로고
    • On the antioxidant mechanisms of Bcl-2: A retrospective of NF-κB signaling and oxidative stress
    • Haddad JJ. On the antioxidant mechanisms of Bcl-2: a retrospective of NF-κB signaling and oxidative stress. Biochem Biophys Res Commun 2004; 322: 355-63.
    • (2004) Biochem Biophys Res Commun , vol.322 , pp. 355-363
    • Haddad, J.J.1
  • 169
    • 17044395507 scopus 로고    scopus 로고
    • L-γ-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: A signaling transcriptional scenario for redox(y) immunologic sensor(s)?
    • Haddad JJ, Harb HL. L-γ-Glutamyl-L-cysteinyl-glycine (glutathione; GSH) and GSH-related enzymes in the regulation of pro- and anti-inflammatory cytokines: a signaling transcriptional scenario for redox(y) immunologic sensor(s)? Mol Immunol 2005; 42: 987-1014.
    • (2005) Mol Immunol , vol.42 , pp. 987-1014
    • Haddad, J.J.1    Harb, H.L.2
  • 171
    • 0011986806 scopus 로고    scopus 로고
    • Inhibition of nuclear factor-κB (NF-κB): An emerging theme in anti-inflammatory therapies
    • D'Acquisto F, May MJ, Ghosh S. Inhibition of nuclear factor-κB (NF-κB): an emerging theme in anti-inflammatory therapies. Mol Intervent 2002; 2: 22-35.
    • (2002) Mol Intervent , vol.2 , pp. 22-35
    • D'Acquisto, F.1    May, M.J.2    Ghosh, S.3


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